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MODELE BIO-TRIBOLOGIQUE DES ARTICULATIONS. ROLE MECANIQUE ET PHYSICOCHIMIQUE DES ASSEMBLAGES MOLECULAIRES DU FLUIDE SYNOVIAL.

Abstract : THE AIM OF THIS WORK IS TO ANALYZE THE ROLE OF THE MOLECULAR ASSEMBLIES OF THE SYNOVIAL FLUID IN THE TRIBOLOGICAL FUNCTION OF A HEALTHY OR PROSTHETIC NATURAL JOINT. FOR THAT, IT WAS CONCEIVED AND USED A REALISTIC EX VIVO MODEL CAPABLE OF REPRODUCING THE MECHANICAL AND PHYSIOCHEMICAL CHARACTERISTICS OF THE NATURAL JOINT. THIS MODEL RECONSTITUTES: THE PROPERTIES OF ARTICULAR CARTILAGE USING POLYMERIC MATERIALS LIKE HYDROGELS, THE STRUCTURES ASSOCIATED WITH SYNOVIAL FLUID (LIPIDIC MULTILAYER AND SYNOVIAL GEL VESICLES) USING NANOSTRUCTURAL PHYSICS TECHNIQUES AS LIPIDIC DEPOSIT BY BURSTING OF BLISTERS AND CO-ADSORPTION OF MICELLES, FABRICATION OF LIPOSOMES AND ATOMIC FORCE MICROSCOPY. THE EVOLUTION OF THESE MOLECULAR ASSEMBLIES DURING FRICTION TESTS IS VISUALIZED IN SITU USING FLUORESCENCE MICROSCOPY AND FLUORESCENTS MOLECULAR MARKERS. THE EXPERIMENTAL RESULTS CORRELATED WITH A NUMERICAL MODEL FOR THE LIPIDIC MULTILAYER ALLOW LOCATING WHERE AND HOW IS CARRIED OUT THE VELOCITY ACCOMMODATION BETWEEN THE MOLECULAR ASSEMBLIES OF SYNOVIAL FLUID IN ORDER TO EXPLAIN THE ORIGINS OF THE VALUES OBTAINED AFTER FRICTION FORCE MEASUREMENTS. AS AN EXAMPLE, IF THE VELOCITY ACCOMMODATION IS LOCALIZED IN THE SYNOVIAL GEL, FRICTION COEFFICIENT IS 0.15, WHEREAS IT IS JUST 0.0015 WHEN THE ACCOMMODATION IS LOCALIZED BETWEEN THE LIPIDIC MULTILAYER. AS FOR APPLICATIONS, OTHER RESULTS SHOWED THAT THE HYDROGEL, USED AS ARTICULAR CARTILAGE MODEL, FAVORS THE FORMATION AND PRESERVATION OF LIPIDIC MULTILAYER, BUT THIS IS NOT THE CASE FOR THE IMPLANTS MATERIALS SUCH AS STAINLESS STEEL AND POLYETHYLENE.
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https://tel.archives-ouvertes.fr/tel-00137339
Contributor : Ana-Maria Trunfio <>
Submitted on : Monday, March 19, 2007 - 3:12:48 PM
Last modification on : Saturday, December 19, 2020 - 6:34:02 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 3:02:10 AM

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  • HAL Id : tel-00137339, version 1

Citation

Ana-Maria Trunfio. MODELE BIO-TRIBOLOGIQUE DES ARTICULATIONS. ROLE MECANIQUE ET PHYSICOCHIMIQUE DES ASSEMBLAGES MOLECULAIRES DU FLUIDE SYNOVIAL.. Sciences du Vivant [q-bio]. INSA de Lyon, 2002. Français. ⟨tel-00137339⟩

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