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Theses
Synthèse de sondes du transporteur des sucres chez Plasmodium falciparum
Synthèse de sondes du transporteur des sucres chez Plasmodium falciparum
Abstract : The malaria, the disease provoked by the parasite Plasmodium, kills every year 1,5 to 2,7 million persons in the world. The discovery of a specific protein (PfHT) responsible for the transport of the sugar necesssary for the parasite to develop within the red corpuscles which it infects, lets envisage that this protein can become a new therapeutic target.
The present work concerned the preparation of around thirty by-products of the glucose variously substituted in -3, to know better the influence of the nature, as well as the hydrophilie or the hydrophobia of these substituants, on the inhibition of the protein of transport of sugars at Plasmodium.
Besides, same substituting (the motive undec-10-enyle) was introduced in a systematic way on the other positions of the glucose, both on oxygens and on carbons.
The present work concerned the preparation of around thirty by-products of the glucose variously substituted in -3, to know better the influence of the nature, as well as the hydrophilie or the hydrophobia of these substituants, on the inhibition of the protein of transport of sugars at Plasmodium.
Besides, same substituting (the motive undec-10-enyle) was introduced in a systematic way on the other positions of the glucose, both on oxygens and on carbons.
Cited literature [19 references]
https://tel.archives-ouvertes.fr/tel-00136723
Contributor : Marina Ionita <>
Submitted on : Thursday, March 15, 2007 - 10:48:20 AM
Last modification on : Friday, November 6, 2020 - 4:04:32 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 11:45:34 PM
Contributor : Marina Ionita <>
Submitted on : Thursday, March 15, 2007 - 10:48:20 AM
Last modification on : Friday, November 6, 2020 - 4:04:32 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 11:45:34 PM