D. T. Achord, F. E. Brot, C. E. Bell, and W. S. Sly, Human ??-glucuronidase: In vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells, Cell, vol.15, issue.1, pp.269-78, 1978.
DOI : 10.1016/0092-8674(78)90102-2

Y. Adachi, B. U. Bradford, W. Gao, H. K. Bojes, and R. G. Thurman, Inactivation of Kupffer cells prevents early alcohol-induced liver injury, Hepatology, vol.28, issue.2, pp.453-60, 1994.
DOI : 10.1002/hep.1840200227

R. Aebersold and M. Mann, Mass spectrometry-based proteomics, Nature, vol.1, issue.6928, pp.198-207, 2003.
DOI : 10.1016/S0960-9822(01)00632-7

C. Alvarez-dominguez, A. M. Barbieri, W. Beron, A. Wandinger-ness, and P. D. Stahl, Phagocytosed live Listeria monocytogenes influences Rab5- regulated in vitro phagosome-endosome fusion, J Biol Chem, vol.271, pp.13834-13877, 1996.

A. Amar-costesec, M. Prado-figueroa, H. Beaufay, J. F. Nagelkerke, and T. J. Van-berkel, Analytical study of microsomes and isolated subcellular membranes from rat liver. IX. Nicotinamide adenine dinucleotide glycohydrolase: a plasma membrane enzyme prominently found in Kupffer cells, The Journal of Cell Biology, vol.100, issue.1, pp.189-97, 1985.
DOI : 10.1083/jcb.100.1.189

J. S. Andersen and M. Mann, Organellar proteomics: turning inventories into insights, EMBO reports, vol.4, issue.9, pp.874-883, 2006.
DOI : 10.1038/nature01031
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559674

F. Aniento, N. Emans, G. Griffiths, and J. Gruenberg, Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397], The Journal of Cell Biology, vol.123, issue.6, pp.1373-87, 1993.
DOI : 10.1083/jcb.123.6.1373

I. M. Arias, H. Popper, D. Schachter, and D. A. Shafritz, The liver ? Biology and pathology, 1982.

S. Arii and M. Imamura, Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury, Journal of Hepato-Biliary-Pancreatic Surgery, vol.7, issue.1, pp.40-48, 2000.
DOI : 10.1007/s005340050152

M. Babst, D. J. Katzmann, W. B. Snyder, B. Wendland, and S. D. Emr, Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body, Developmental Cell, vol.3, issue.2, pp.283-292, 2002.
DOI : 10.1016/S1534-5807(02)00219-8

R. D. Bagshaw, D. J. Mahuran, and J. W. Callahan, A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle, Molecular & Cellular Proteomics, vol.4, issue.2, pp.133-176, 2005.
DOI : 10.1074/mcp.M400128-MCP200

A. C. Bakker, P. Webster, W. A. Jacob, and N. W. Andrews, Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts, J Cell Sci, vol.110, pp.2227-2265, 1997.

E. Bananis, S. Nath, K. Gordon, P. Satir, R. J. Stockert et al., Microtubule-Dependent Movement of Late Endocytic Vesicles In Vitro: Requirements for Dynein and Kinesin, Molecular Biology of the Cell, vol.15, issue.8, pp.3688-97, 2004.
DOI : 10.1091/mbc.E04-04-0278

J. Bartholeyns, C. Peeters-joris, and P. Baudhuin, Hepatic Nucleases. Extrahepatic Origin and Association of Neutral Liver Ribonuclease with Lysosomes, European Journal of Biochemistry, vol.217, issue.2, pp.385-93, 1975.
DOI : 10.1016/0006-291X(72)90310-5

S. Brunet, P. Thibault, E. Gagnon, P. Kearney, J. J. Bergeron et al., Organelle proteomics: looking at less to see more, Trends in Cell Biology, vol.13, issue.12, pp.629-667, 2003.
DOI : 10.1016/j.tcb.2003.10.006

N. L. Bucher, The biosynthesis of Terpenes and Sterols, Ciba Found. Symp, vol.46, 1959.

J. Burnside and D. L. Schneider, Characterization of the membrane proteins of rat liver lysosomes. Composition, enzyme activities and turnover, Biochemical Journal, vol.204, issue.2, pp.525-559, 1982.
DOI : 10.1042/bj2040525

E. D. Carstea, J. A. Morris, K. G. Coleman, S. K. Loftus, D. Zhang et al., Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis, Science, vol.277, issue.5323, pp.228-259, 1997.
DOI : 10.1126/science.277.5323.228

P. J. Casey, Protein lipidation in cell signaling, Science, vol.268, issue.5208, pp.221-226, 1995.
DOI : 10.1126/science.7716512

S. D. Conner and S. L. Schmid, Regulated portals of entry into the cell, Nature, vol.277, issue.6927, pp.37-44, 2003.
DOI : 10.1038/nature01451

M. Foti, A. Mangasarian, V. Piguet, D. P. Lew, K. H. Krause et al., Nef-mediated Clathrin-coated Pit Formation, The Journal of Cell Biology, vol.103, issue.1, pp.37-47, 1997.
DOI : 10.1073/pnas.78.11.6967
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139808

S. L. Friedman, Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies, N Engl J Med, vol.328, pp.1828-1863, 1993.

C. E. Futter, L. M. Collinson, J. M. Backer, and C. R. Hopkins, Human VPS34 is required for internal vesicle formation within multivesicular endosomes, The Journal of Cell Biology, vol.10, issue.7, pp.1251-64, 2001.
DOI : 10.1083/jcb.200108152
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199316

R. Gagescu, N. Demaurex, R. G. Parton, W. Hunziker, L. A. Huber et al., The Recycling Endosome of Madin-Darby Canine Kidney Cells Is a Mildly Acidic Compartment Rich in Raft Components, Molecular Biology of the Cell, vol.11, issue.8, pp.2775-91, 2000.
DOI : 10.1091/mbc.11.8.2775

E. Gagnon, S. Duclos, C. Rondeau, E. Chevet, P. H. Cameron et al., Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages, Cell, vol.110, issue.1, pp.119-150, 2002.
DOI : 10.1016/S0092-8674(02)00797-3

C. Galaviz-hernandez, C. Stagg, G. De-ridder, T. S. Tanaka, M. S. Ko et al., Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis, Gene, vol.309, issue.2, pp.81-90, 2003.
DOI : 10.1016/S0378-1119(03)00508-0

J. Garin, R. Diez, S. Kieffer, J. F. Dermine, S. Duclos et al., The Phagosome Proteome, The Journal of Cell Biology, vol.93, issue.1, pp.165-80, 2001.
DOI : 10.1093/emboj/19.3.349

H. J. Geuze, J. W. Slot, G. J. Strous, H. F. Lodish, and A. L. Schwartz, Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis, Cell, vol.32, issue.1, pp.277-87, 1983.
DOI : 10.1016/0092-8674(83)90518-4

E. E. Bailey, E. Eichler, and . Tuzun, Genome sequence of the Brown Norway rat yields insights into mammalian evolution, Nature, vol.428, pp.493-521, 2004.

D. J. Gillooly, I. C. Morrow, M. Lindsay, R. Gould, N. J. Bryant et al., Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells, The EMBO Journal, vol.19, issue.17, pp.4577-88, 2000.
DOI : 10.1093/emboj/19.17.4577

C. Glass, R. C. Pittman, M. Civen, and D. Steinberg, Uptake of high-density lipoprotein-associated apoprotein A-I and cholesterol esters by 16 tissues of the rat in vivo and by adrenal cells and hepatocytes in vitro, J Biol Chem, vol.260, pp.744-50, 1985.

S. Greenberg, K. Burridge, and S. C. Silverstein, Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages, Journal of Experimental Medicine, vol.172, issue.6, pp.1853-1859, 1990.
DOI : 10.1084/jem.172.6.1853

G. Griffiths, B. Hoflack, K. Simons, I. Mellman, and S. Kornfeld, The mannose 6-phosphate receptor and the biogenesis of lysosomes, Cell, vol.52, issue.3, pp.329-370, 1988.
DOI : 10.1016/S0092-8674(88)80026-6

G. Griffiths, On vesicles and membrane compartments, Protoplasma, vol.5, issue.1-4, pp.37-58, 1996.
DOI : 10.1007/BF01279185

J. Gruenberg, The endocytic pathway: a mosaic of domains, Nature Reviews Molecular Cell Biology, vol.108, issue.10, pp.721-751, 2001.
DOI : 10.1038/35096054

J. Gruenberg and F. R. Maxfield, Membrane transport in the endocytic pathway, Current Opinion in Cell Biology, vol.7, issue.4, pp.552-63, 1995.
DOI : 10.1016/0955-0674(95)80013-1

J. Gruenberg and H. Stenmark, Opinion: The biogenesis of multivesicular endosomes, Nature Reviews Molecular Cell Biology, vol.5, issue.4, pp.317-340, 2004.
DOI : 10.1038/nrm1360

J. Gruenberg, G. Griffiths, and K. E. Howell, Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro, The Journal of Cell Biology, vol.108, issue.4, pp.1301-1317, 1989.
DOI : 10.1083/jcb.108.4.1301

K. Hannig, Eine Neuentwicklung der tr??gerfreien kontinuierlichen Elektrophorese. Zur Trennung hochmolekularer und grobdisperser Teilchen, Hoppe-Seyler??s Zeitschrift f??r physiologische Chemie, vol.338, issue.Jahresband, pp.211-238, 1964.
DOI : 10.1515/bchm2.1964.338.1-2.211

C. Harding, J. Heuser, and P. Stahl, Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes, The Journal of Cell Biology, vol.97, issue.2, pp.329-368, 1983.
DOI : 10.1083/jcb.97.2.329

H. Hayashi, S. Niinobe, Y. Matsumoto, and T. Suga, Effects of Triton WR-1339 on Lipoprotein Lipolytic Activity and Lipid Content of Rat Liver Lysosomes, The Journal of Biochemistry, vol.89, issue.2, pp.573-582, 1981.
DOI : 10.1093/oxfordjournals.jbchem.a133233

A. Helenius, I. Mellman, D. Wall, and A. Hubbard, Endosomes, Trends in Biochemical Sciences, vol.8, issue.7, pp.245-50, 1983.
DOI : 10.1016/0968-0004(83)90350-X

H. G. Hers, ??-Glucosidase deficiency in generalized glycogen-storage disease (Pompe's disease), Biochemical Journal, vol.86, issue.1, pp.11-17, 1963.
DOI : 10.1042/bj0860011

L. Hicke and R. Dunn, Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins, Annual Review of Cell and Developmental Biology, vol.19, issue.1, pp.141-72, 2003.
DOI : 10.1146/annurev.cellbio.19.110701.154617

B. Hoflack, K. Fujimoto, and S. Kornfeld, The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor, J Biol Chem, vol.262, pp.123-132, 1987.

C. R. Hopkins, Intracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells, Cell, vol.35, issue.1, pp.321-351, 1983.
DOI : 10.1016/0092-8674(83)90235-0

M. Houde, S. Bertholet, E. Gagnon, S. Brunet, G. Goyette et al., Phagosomes are competent organelles for antigen cross-presentation, Nature, vol.425, issue.6956, pp.402-408, 2003.
DOI : 10.1038/nature01912

D. H. Hsu, P. Paz, G. Villaflor, A. Rivas, A. Mehta-damani et al., Exosomes as a Tumor Vaccine: Enhancing Potency Through Direct Loading of Antigenic Peptides, Journal of Immunotherapy, vol.26, issue.5, pp.440-50, 2003.
DOI : 10.1097/00002371-200309000-00007

A. L. Hubbard, G. Wilson, G. Ashwell, and H. Stukenbrok, An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. I. Distribution of 125I-ligands among the liver cell types, The Journal of Cell Biology, vol.83, issue.1, pp.47-64, 1979.
DOI : 10.1083/jcb.83.1.47

E. J. Hughson and C. R. Hopkins, Endocytic pathways in polarized Caco-2 cells: identification of an endosomal compartment accessible from both apical and basolateral surfaces, The Journal of Cell Biology, vol.110, issue.2, pp.337-385, 1990.
DOI : 10.1083/jcb.110.2.337

E. Ikonen, Roles of lipid rafts in membrane transport, Current Opinion in Cell Biology, vol.13, issue.4, pp.470-477, 2001.
DOI : 10.1016/S0955-0674(00)00238-6

P. J. Jacques, Epuration plasmique de protéines étrangères, leur capture et leur destinée dans l'appareil vacuolaire du foie, Thèse de l, 1968.

M. Jadot, S. Wattiaux-de-coninck, and R. Wattiaux, Effect on lysosomes of invertase endocytosed by rat-liver, European Journal of Biochemistry, vol.99, issue.3, pp.485-493, 1985.
DOI : 10.1016/0014-5793(78)80488-8

M. Jadot, S. Misquith, F. Dubois, S. Wattiaux-de-coninck, and R. Wattiaux, Intracellular pathway followed by invertase endocytosed by rat liver, European Journal of Biochemistry, vol.218, issue.3, pp.695-700, 1986.
DOI : 10.1083/jcb.83.1.47

M. Jadot, Chemin intracellulaire suivi par l'invertase endocytée par le foie : une analyse biochimique, Thèse des Facultés, 1987.

M. Jadot, L. Lin, D. E. Sleat, I. Sohar, M. S. Hsu et al., Subcellular Localization of Mannose 6-Phosphate Glycoproteins in Rat Brain, Journal of Biological Chemistry, vol.274, issue.30, pp.21104-21117, 1999.
DOI : 10.1074/jbc.274.30.21104

A. Jahraus, B. Storrie, G. Griffiths, and M. Desjardins, Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment, J Cell Sci, vol.107, pp.145-57, 1994.

M. Jin and M. D. Snider, Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex, J Biol Chem, vol.268, pp.18390-18397, 1993.

R. M. Johnstone, M. Adam, J. R. Hammond, L. Orr, and C. Turbide, Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes), J Biol Chem, vol.262, pp.9412-9432, 1987.

K. A. Joiner, S. A. Fuhrman, H. M. Miettinen, L. H. Kasper, and I. Mellman, Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts, Science, vol.249, issue.4969, pp.641-647, 1990.
DOI : 10.1126/science.2200126

A. Journet, A. Chapel, S. Kieffer, F. Roux, and J. Garin, Proteomic analysis of human lysosomes: Application to monocytic and breast cancer cells, PROTEOMICS, vol.2, issue.8, pp.1026-1066, 2002.
DOI : 10.1002/1615-9861(200208)2:8<1026::AID-PROT1026>3.0.CO;2-I

A. Journet, A. Chapel, S. Kieffer, M. Louwagie, S. Luche et al., Towards a human repertoire of monocytic lysosomal proteins, Electrophoresis, vol.324, issue.16, pp.3411-3420, 2000.
DOI : 10.1002/1522-2683(20001001)21:16<3411::AID-ELPS3411>3.0.CO;2-M

K. Jungermann and N. Katz, Metabolic heterogenity of liver parenchyma ; in: Metabolic compartimentation. Academic press London, pp.411-435, 1982.

I. Jutras and M. Desjardins, PHAGOCYTOSIS: At the Crossroads of Innate and Adaptive Immunity, Annual Review of Cell and Developmental Biology, vol.21, issue.1, pp.511-538, 2005.
DOI : 10.1146/annurev.cellbio.20.010403.102755

D. Kasper, F. Dittmer, K. Figura, and R. Pohlmann, Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes, The Journal of Cell Biology, vol.134, issue.3, pp.615-638, 1996.
DOI : 10.1083/jcb.134.3.615

D. J. Katzmann, M. Babst, and S. D. Emr, Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I, Cell, vol.106, issue.2, pp.145-55, 2001.
DOI : 10.1016/S0092-8674(01)00434-2

D. J. Katzmann, G. Odorizzi, and S. D. Emr, Receptor downregulation and multivesicular-body sorting, Nature Reviews Molecular Cell Biology, vol.8, issue.12, pp.893-905, 2002.
DOI : 10.1038/nrm973

S. J. Kil and C. Carlin, EGF receptor residues Leu679, Leu680 mediate selective sorting of ligand-receptor complexes in early endosomal compartments, Journal of Cellular Physiology, vol.9, issue.1, pp.47-60, 2000.
DOI : 10.1002/1097-4652(200010)185:1<47::AID-JCP4>3.0.CO;2-O

J. Klose and U. Kobalz, Two-dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome, Electrophoresis, vol.8, issue.1, pp.1034-59, 1995.
DOI : 10.1002/elps.11501601175

A. Knight, E. Hughson, C. R. Hopkins, and D. F. Cutler, Membrane protein trafficking through the common apical endosome compartment of polarized Caco-2 cells., Molecular Biology of the Cell, vol.6, issue.5, pp.597-610, 1995.
DOI : 10.1091/mbc.6.5.597

T. Kobayashi, E. Stang, K. S. Fang, P. De-moerloose, R. G. Parton et al., A lipid associated with the antiphospholipid syndrome regulates endosome structure and function, Nature, vol.89, issue.6672, pp.193-200, 1998.
DOI : 10.1038/32440

L. Lehle, R. E. Cohen, and C. E. Ballou, Carbohydrate structure of yeast invertase. Demonstration of a form with only core oligosaccharides and a form with completed polysaccharide chains, J Biol Chem, vol.254, pp.12209-12227, 1979.

F. Leighton, H. Poole, P. Beaufay, J. W. Baudhuin, S. Coffey et al., THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339: Improved Isolation Procedures, Automated Analysis, Biochemical and Morphological Properties of Fractions, The Journal of Cell Biology, vol.37, issue.2, pp.482-513, 1968.
DOI : 10.1083/jcb.37.2.482

Y. Li, K. Rogulski, Q. Zhou, P. J. Sims, and E. V. Prochownik, The Negative c-Myc Target Onzin Affects Proliferation and Apoptosis via Its Obligate Interaction with Phospholipid Scramblase I, Molecular and Cellular Biology, vol.26, issue.9, pp.3401-3414, 2006.
DOI : 10.1128/MCB.26.9.3401-3413.2006

O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, Protein measurement with the Folin phenol reagent, J Biol Chem, vol.193, pp.265-75, 1951.

S. Luche, V. Santoni, and T. Rabilloud, Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis, PROTEOMICS, vol.3, issue.3, pp.249-53, 2003.
DOI : 10.1002/pmic.200390037
URL : https://hal.archives-ouvertes.fr/hal-00116013

T. Ludwig, H. Munier-lehmann, U. Bauer, M. Hollinshead, C. Ovitt et al., Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts, Embo J, vol.13, pp.3430-3437, 1994.
URL : https://hal.archives-ouvertes.fr/pasteur-00167086

D. Z. Luo, D. Vermijlen, B. Ahishali, V. Triantis, G. Plakoutsi et al., On the cell biology of pit cells, the liver-specific NK cells, World Journal of Gastroenterology, vol.6, issue.1, pp.1-11, 2000.
DOI : 10.3748/wjg.v6.i1.1

J. P. Luzio, P. Pryor, S. R. Gray, M. Gratian, R. C. Piper et al., Membrane traffic to and from lysosomes., Biochemical Society Symposium, vol.72, pp.77-86, 2005.
DOI : 10.1042/bss0720077

V. L. Mackay, X. Li, M. R. Flory, E. Turcott, G. L. Law et al., Gene Expression Analyzed by High-resolution State Array Analysis and Quantitative Proteomics: Response of Yeast to Mating Pheromone, Molecular & Cellular Proteomics, vol.3, issue.5, pp.478-89, 2004.
DOI : 10.1074/mcp.M300129-MCP200

D. H. Maclennan and J. Asai, Studies on the mitochondrial adenosine triphosphatase system V. Localization of the oligomycin-sensitivity conferring protein, Biochemical and Biophysical Research Communications, vol.33, issue.3, pp.441-448, 1968.
DOI : 10.1016/0006-291X(68)90592-5

D. H. Maclennan and A. Tzagoloff, Mitochondrial adenosine triphosphatase system. IV. Purification and characterization of the oligomycin sensitivity-conferring protein, Biochemistry, vol.7, issue.4, pp.1603-1613, 1968.
DOI : 10.1021/bi00844a050

M. Malissen, A. Gillet, L. Ardouin, G. Bouvier, J. Trucy et al., Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene, Embo J, vol.14, pp.4641-53, 1995.

F. Martinez, E. R. Abril, D. L. Earnest, and R. R. Watson, Ethanol and cytokine secretion, Alcohol, vol.9, issue.6, pp.455-463, 1992.
DOI : 10.1016/0741-8329(92)90080-T

H. Matsuo, J. Chevallier, N. Mayran, I. L. Blanc, C. Ferguson et al., Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization, Science, vol.303, issue.5657, pp.531-535, 2004.
DOI : 10.1126/science.1092425

F. R. Maxfield, J. Schlessinger, Y. Shechter, I. Pastan, and M. C. Willingham, Collection of insulin, EGF and ??2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization, Cell, vol.14, issue.4, pp.805-815, 1978.
DOI : 10.1016/0092-8674(78)90336-7

S. Mayor, S. Sabharanjak, and F. R. Maxfield, Cholesterol-dependent retention of GPI-anchored proteins in endosomes, The EMBO Journal, vol.17, issue.16, pp.4626-4664, 1998.
DOI : 10.1093/emboj/17.16.4626

L. S. Mayorga, F. Bertini, and P. D. Stahl, Fusion of newly formed phagosomes with endosomes in intact cells and in a cell-free system, J Biol Chem, vol.266, pp.6511-6518, 1991.

N. Mayran, R. G. Parton, and J. Gruenberg, Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells, The EMBO Journal, vol.22, issue.13, pp.3242-53, 2003.
DOI : 10.1093/emboj/cdg321

A. L. Mccormack, D. M. Schieltz, B. Goode, S. Yang, G. Barnes et al., Direct Analysis and Identification of Proteins in Mixtures by LC/MS/MS and Database Searching at the Low-Femtomole Level, Analytical Chemistry, vol.69, issue.4, pp.767-76, 1997.
DOI : 10.1021/ac960799q

P. J. Meikle, J. J. Hopwood, A. E. Clague, and W. F. Carey, Prevalence of Lysosomal Storage Disorders, JAMA, vol.281, issue.3, pp.249-54, 1999.
DOI : 10.1001/jama.281.3.249

I. Mellman, ENDOCYTOSIS AND MOLECULAR SORTING, Annual Review of Cell and Developmental Biology, vol.12, issue.1, pp.575-625, 1996.
DOI : 10.1146/annurev.cellbio.12.1.575

B. M. Mullock, J. H. Perez, T. Kuwana, S. R. Gray, and J. P. Luzio, Lysosomes can fuse with a late endosomal compartment in a cell-free system from rat liver, The Journal of Cell Biology, vol.126, issue.5, pp.1173-82, 1994.
DOI : 10.1083/jcb.126.5.1173

B. M. Mullock, N. A. Bright, C. W. Fearon, S. R. Gray, and J. P. Luzio, Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent, The Journal of Cell Biology, vol.66, issue.3, pp.591-601, 1998.
DOI : 10.1016/0955-0674(93)90130-I

R. F. Murphy, Maturation models for endosome and lysosome biogenesis, Trends in Cell Biology, vol.1, issue.4, pp.77-82, 1991.
DOI : 10.1016/0962-8924(91)90022-2

Q. N. Myrvik, A. G. Gristina, G. Giridhar, and H. Hayakawa, Particleinduced in vivo priming of alveolar macrophages for enhanced oxidative responses: a novel system of cellular immune augmentation, J Leukoc Biol, vol.54, pp.439-482, 1993.

M. Naito, K. Takahashi, and S. Nishikawa, Development, differentiation, and maturation of macrophages in the fetal mouse liver, J Leukoc Biol, vol.48, pp.27-37, 1990.

G. Odorizzi, M. Babst, and S. D. Emr, Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body, Cell, vol.95, issue.6, pp.847-58, 1998.
DOI : 10.1016/S0092-8674(00)81707-9

G. Odorizzi, M. Babst, and S. D. Emr, Phosphoinositide signaling and the regulation of membrane trafficking in yeast, Trends in Biochemical Sciences, vol.25, issue.5, pp.229-264, 2000.
DOI : 10.1016/S0968-0004(00)01543-7

B. T. Pan, K. Teng, C. Wu, M. Adam, and R. M. Johnstone, Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes, The Journal of Cell Biology, vol.101, issue.3, pp.942-950, 1985.
DOI : 10.1083/jcb.101.3.942

E. Parise, M. E. Taylor, and J. A. Summerfield, Localization of a carbohydrate mediated glycoprotein receptor on hepatic sinusoidal cells; in: Sinusoidal Liver Cells, pp.287-296, 1982.

A. C. Parks, Intermediates in the degradation of yeast invertase. Thesis, 1980.

I. Pastan and M. C. Willingham, Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi, Trends in Biochemical Sciences, vol.8, issue.7, pp.250-254, 1983.
DOI : 10.1016/0968-0004(83)90351-1

S. H. Pasternak, R. D. Bagshaw, M. Guiral, S. Zhang, C. A. Ackerley et al., Presenilin-1, Nicastrin, Amyloid Precursor Protein, and ??-Secretase Activity Are Co-localized in the Lysosomal Membrane, Journal of Biological Chemistry, vol.278, issue.29, pp.26687-94, 2003.
DOI : 10.1074/jbc.M304009200

A. Petiot, J. Faure, H. Stenmark, and J. Gruenberg, PI3P signaling regulates receptor sorting but not transport in the endosomal pathway, The Journal of Cell Biology, vol.12, issue.6, pp.971-980, 2003.
DOI : 10.1016/S0955-0674(00)00240-4

V. Piguet, F. Gu, M. Foti, N. Demaurex, J. Gruenberg et al., Nef-Induced CD4 Degradation, Cell, vol.97, issue.1, pp.63-73, 1999.
DOI : 10.1016/S0092-8674(00)80715-1
URL : http://doi.org/10.1016/s0092-8674(00)80715-1

A. Pitt, L. S. Mayorga, A. L. Schwartz, and P. D. Stahl, Transport of phagosomal components to an endosomal compartment, J Biol Chem, vol.267, pp.126-158, 1992.

Y. Poumay and M. F. , Rapid preparative isolation of concentrated low density lipoproteins and of lipoprotein-deficient serum using vertical rotor gradient ultracentrifugation, J Lipid Res, vol.26, pp.1476-80, 1985.

S. Rabinowitz, H. Horstmann, S. Gordon, and G. Griffiths, Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages, The Journal of Cell Biology, vol.116, issue.1, pp.95-112, 1992.
DOI : 10.1083/jcb.116.1.95

G. Raposo, H. W. Nijman, W. Stoorvogel, R. Liejendekker, C. V. Harding et al., B lymphocytes secrete antigen-presenting vesicles, Journal of Experimental Medicine, vol.183, issue.3, pp.1161-72, 1996.
DOI : 10.1084/jem.183.3.1161
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192324

N. D. Rawlings and A. J. Barrett, Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1429, issue.2, pp.496-500, 1999.
DOI : 10.1016/S0167-4838(98)00238-6

M. D. Resh, Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1451, issue.1, pp.1-16, 1999.
DOI : 10.1016/S0167-4889(99)00075-0

C. J. Roberts, G. Pohlig, J. H. Rothman, and T. H. Stevens, Structure, biosynthesis, and localization of dipeptidyl aminopeptidase B, an integral membrane glycoprotein of the yeast vacuole, The Journal of Cell Biology, vol.108, issue.4, pp.1363-73, 1989.
DOI : 10.1083/jcb.108.4.1363

A. C. Rodloff, J. Becker, D. K. Blanchard, T. W. Klein, H. Hahn et al., Inhibition of macrophage phagocytosis by Bacteroides fragilis in vivo and in vitro, Infect Immun, vol.52, pp.488-92, 1986.

M. Roederer, J. R. Barry, R. B. Wilson, and R. F. Murphy, Endosomes can undergo an ATP-dependent density increase in the absence of dense lysosomes, Eur J Cell Biol, vol.51, pp.229-263, 1990.

K. Rogulski, Y. Li, K. Rothermund, L. Pu, S. Watkins et al., Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt???Mdm2???p53 pathway, Oncogene, vol.12, issue.51, pp.7524-7565, 2005.
DOI : 10.1053/sonc.2002.34057

T. K. Sato, M. Overduin, and S. D. Emr, Location, Location, Location: Membrane Targeting Directed by PX Domains, Science, vol.294, issue.5548, pp.1881-1886, 2001.
DOI : 10.1126/science.1065763

P. H. Schlesinger, T. W. Doebber, B. F. Mandell, R. White, C. Deschryver et al., -d-glucosaminidase, ribonuclease B and agalacto-orosomucoid, Biochemical Journal, vol.176, issue.1, pp.103-112, 1978.
DOI : 10.1042/bj1760103
URL : https://hal.archives-ouvertes.fr/hal-00567969

S. Schmid, R. Fuchs, M. Kielian, A. Helenius, and I. Mellman, Acidification of endosome subpopulations in wild-type Chinese hamster ovary cells and temperature-sensitive acidification-defective mutants, The Journal of Cell Biology, vol.108, issue.4, pp.1291-300, 1989.
DOI : 10.1083/jcb.108.4.1291

S. L. Schmid, R. Fuchs, P. Male, and I. Mellman, Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes, Cell, vol.52, issue.1, pp.73-83, 1988.
DOI : 10.1016/0092-8674(88)90532-6

D. R. Sheff, E. A. Daro, M. Hull, and I. Mellman, The Receptor Recycling Pathway Contains Two Distinct Populations of Early Endosomes with Different Sorting Functions, The Journal of Cell Biology, vol.257, issue.1, pp.123-162, 1999.
DOI : 10.1083/jcb.140.5.1039

V. S. Sheorain, T. N. Rao, and D. Subrahmanyam, On the inhibition of lipoprotein lipase by Triton WR 1339, Enzyme, vol.25, pp.81-87, 1980.

Y. Shinkai, G. Rathbun, K. P. Lam, E. M. Oltz, V. Stewart et al., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement, Cell, vol.68, issue.5, pp.855-67, 1992.
DOI : 10.1016/0092-8674(92)90029-C

A. Simonsen, R. Lippe, S. Christoforidis, J. M. Gaullier, A. Brech et al., EEA1 links PI(3)K function to Rab5 regulation of endosome fusion, Nature, vol.394, pp.494-502, 1998.

D. E. Sleat, I. Sohar, H. Lackland, J. Majercak, and P. Lobel, Rat Brain Contains High Levels of Mannose-6-phosphorylated Glycoproteins Including Lysosomal Enzymes and Palmitoyl-Protein Thioesterase, an Enzyme Implicated in Infantile Neuronal Lipofuscinosis, Journal of Biological Chemistry, vol.271, issue.32, pp.19191-19199, 1996.
DOI : 10.1074/jbc.271.32.19191

D. E. Sleat, S. R. Kraus, I. Sohar, H. Lackland, and P. Lobel, -acetylglucosamine-6-sulphatase are the major mannose-6-phosphate glycoproteins in human urine, Biochemical Journal, vol.324, issue.1, pp.33-42, 1997.
DOI : 10.1042/bj3240033

D. E. Sleat, R. J. Donnelly, H. Lackland, C. G. Liu, I. Sohar et al., Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid Lipofuscinosis, Science, vol.277, issue.5333, pp.1802-1807, 1997.
DOI : 10.1126/science.277.5333.1802

D. E. Sleat, H. Lackland, Y. Wang, I. Sohar, G. Xiao et al., The human brain mannose 6-phosphate glycoproteome: A complex mixture composed of multiple isoforms of many soluble lysosomal proteins, PROTEOMICS, vol.426, issue.6, pp.1520-1552, 2005.
DOI : 10.1002/pmic.200401054

D. E. Sleat, Y. Wang, I. Sohar, H. Lackland, Y. Li et al., Identification and Validation of Mannose 6-Phosphate Glycoproteins in Human Plasma Reveal a Wide Range of Lysosomal and Non-lysosomal Proteins, Molecular & Cellular Proteomics, vol.5, issue.10, pp.1942-1956, 2006.
DOI : 10.1074/mcp.M600030-MCP200

M. B. Soares, M. F. Bonaldo, P. Jelene, L. Su, L. Lawton et al., Construction and characterization of a normalized cDNA library., Proceedings of the National Academy of Sciences, vol.91, issue.20, pp.9228-9260, 1994.
DOI : 10.1073/pnas.91.20.9228

R. Stahn, K. P. Maier, and K. Hannig, A NEW METHOD FOR THE PREPARATION OF RAT LIVER LYSOSOMES: Separation of Cell Organelles of Rat Liver by Carrier-Free Continuous Electrophoresis, The Journal of Cell Biology, vol.46, issue.3, pp.576-91, 1970.
DOI : 10.1083/jcb.46.3.576

S. J. Steinberg, C. P. Ward, and A. H. Fensom, Complementation studies in Niemann-Pick disease type C indicate the existence of a second group., Journal of Medical Genetics, vol.31, issue.4, pp.317-337, 1994.
DOI : 10.1136/jmg.31.4.317

B. Storrie, Assembly of Lysosomes: Perspectives from Comparative Molecular Cell Biology, Int Rev Cytol, vol.111, pp.53-105, 1988.
DOI : 10.1016/S0074-7696(08)61731-3

B. Storrie and M. Desjardins, The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?, BioEssays, vol.131, issue.11, pp.895-903, 1996.
DOI : 10.1002/bies.950181108

G. J. Strous and R. Govers, The ubiquitin-proteasome system and endocytosis, J Cell Sci, vol.112, pp.1417-1440, 1999.
URL : https://hal.archives-ouvertes.fr/hal-01478420

J. M. Szajewski and A. Scanu, Effect of triton WR-1339 on the heparininduced plasma lipoprotein lipase activity in dogs, Acta Med Pol, vol.4, pp.15-20, 1963.

C. Thery, L. Duban, E. Segura, P. Veron, O. Lantz et al., Indirect activation of na??ve CD4+ T cells by dendritic cell???derived exosomes, Nature Immunology, vol.3, issue.12, pp.1156-62, 2002.
DOI : 10.1038/ni854

C. Thery, M. Boussac, P. Veron, P. Ricciardi-castagnoli, G. Raposo et al., Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles, The Journal of Immunology, vol.166, issue.12, pp.7309-7327, 2001.
DOI : 10.4049/jimmunol.166.12.7309

. Antignac, A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis, Nat Genet, vol.18, pp.319-343, 1998.

A. Trouet, [Immunization of rabbits by hepatic lysosomes from rats treated with Triton WR 1339], Arch Int Physiol Biochim, vol.72, pp.698-700, 1964.

B. Tycko and F. R. Maxfield, Rapid acidification of endocytic vesicles containing ??2-macroglobulin, Cell, vol.28, issue.3, pp.643-51, 1982.
DOI : 10.1016/0092-8674(82)90219-7

M. Tyers and M. Mann, From genomics to proteomics, Nature, vol.10, issue.6928, pp.193-200, 2003.
DOI : 10.1126/science.291.5507.1192

J. L. Urbanowski and R. C. Piper, Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late-Endosome/Vacuole, Traffic, vol.2, issue.9, pp.622-652, 2001.
DOI : 10.1034/j.1600-0854.2001.20905.x

P. Van-der-sluijs, M. Hull, P. Webster, P. Male, B. Goud et al., The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway, Cell, vol.70, issue.5, pp.729-769, 1992.
DOI : 10.1016/0092-8674(92)90307-X

B. Van-deurs, P. K. Holm, L. Kayser, K. Sandvig, and S. H. Hansen, Multivesicular bodies in HEp-2 cells are maturing endosomes, Eur J Cell Biol, vol.61, pp.208-232, 1993.

J. Van-renswoude, K. R. Bridges, J. B. Harford, and R. D. Klausner, Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment., Proceedings of the National Academy of Sciences, vol.79, issue.20, pp.6186-90, 1982.
DOI : 10.1073/pnas.79.20.6186

K. A. Ke, Z. Ketchum, Y. Lai, Z. Lei, J. Li et al., The sequence of the human genome, Science, vol.291, pp.1304-51, 2001.

F. W. Verheijen, E. Verbeek, N. Aula, C. E. Beerens, A. C. Havelaar et al., A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases, Nature Genetics, vol.23, issue.4, pp.462-467, 1999.
DOI : 10.1038/70585

T. Vida and B. Gerhardt, A Cell-Free Assay Allows Reconstitution of Vps33p-Dependent Transport to the Yeast Vacuole/Lysosome, The Journal of Cell Biology, vol.52, issue.1, pp.85-98, 1999.
DOI : 10.1093/emboj/17.1.127

K. Von-figura and A. Hasilik, Lysosomal Enzymes and their Receptors, Annual Review of Biochemistry, vol.55, issue.1, pp.167-93, 1986.
DOI : 10.1146/annurev.bi.55.070186.001123

R. H. Waterston, K. Lindblad-toh, E. Birney, J. Rogers, J. F. Abril et al., Initial sequencing and comparative analysis of the mouse genome, Nature, vol.420, pp.520-62, 2002.

R. Wattiaux, M. Wibo, and P. Baudhuin, Lysosomes, Ciba Found. Symp, vol.176, 1963.
URL : https://hal.archives-ouvertes.fr/hal-00478700

R. Wattiaux, Etude expérimentale de la surcharge des lysosomes, Thèse de l, 1966.

R. Wattiaux, S. Wattiaux-de-coninck, M. F. , and F. Dubois, Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient, The Journal of Cell Biology, vol.78, issue.2, pp.349-68, 1978.
DOI : 10.1083/jcb.78.2.349

R. Wattiaux, S. Wattiaux-de-coninck-ed, D. Rickwood, and I. R. , Separation of cell organellesIodinated density gradient media. A practical approach, pp.119-137, 1983.

R. Wattiaux, M. Jadot, F. Dubois, S. Wattiaux-de, and . Coninck, Phagocytosis by Rat Liver: Relationships between Phagosomes and Lysosomes, Biochemical and Biophysical Research Communications, vol.220, issue.3, pp.569-74, 1996.
DOI : 10.1006/bbrc.1996.0444

M. G. Wetzel and E. D. Korn, PHAGOCYTOSIS OF LATEX BEADS BY ACANTHAMOEBA CASTELLANII (NEFF): III. Isolation of the Phagocytic Vesicles and Their Membranes, The Journal of Cell Biology, vol.43, issue.1, pp.90-104, 1969.
DOI : 10.1083/jcb.43.1.90

M. Wibo, D. Thines-sempoux, A. Amar-costesec, H. Beaufay, and D. Godelaine, Analytical study of microsomes and isolated subcellular membranes from rat liver VIII. Subfractionation of preparations enriched with plasma membranes, outer mitochondrial membranes, or Golgi complex membranes, The Journal of Cell Biology, vol.89, issue.3, pp.456-74, 1981.
DOI : 10.1083/jcb.89.3.456

J. J. Widmann, R. S. Cotran, and H. D. Fahimi, MONONUCLEAR PHAGOCYTES (KUPFFER CELLS) AND ENDOTHELIAL CELLS: Identification of Two Functional Cell Types in Rat Liver Sinusoids by Endogenous Peroxidase Activity, The Journal of Cell Biology, vol.52, issue.1, pp.159-70, 1972.
DOI : 10.1083/jcb.52.1.159

D. J. Yamashiro, B. Tycko, S. R. Fluss, and F. R. Maxfield, Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway, Cell, vol.37, issue.3, pp.789-800, 1984.
DOI : 10.1016/0092-8674(84)90414-8

J. R. Yates, A. Gilchrist, K. E. Howell, and J. J. Bergeron, Proteomics of organelles and large cellular structures, Nature Reviews Molecular Cell Biology, vol.152, issue.9, pp.702-716, 2005.
DOI : 10.1038/nrm1711

B. Young and J. W. Heath, Wheather's Functional Histology, 2000.

M. X. Zuber, S. M. Strittmatter, and M. C. Fishman, A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43, Nature, vol.341, issue.6240, pp.345-353, 1989.
DOI : 10.1038/341345a0