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Cartographie de gènes à caractères quantitatifs par déséquilibre de liaison

Abstract : The aim of this work is to develop methods for estimating the position of the genes which influence the expression of a continuous trait (QTL). I first propose a numerical algorithm to compute an approximation of the transition density of haplotype frequencies for two biallelic loci with recombination under a diffusion model. I also show that this method can be used for computing the likelihood of a gene position. Then I present a likelihood maximization method for mapping QTL. The likelihood of the QTL position is computed using a first-order approximation based on the expected haplotype frequencies under a three-locus Wright-Fisher model with recombination. I derive an approximation of these expected frequencies. I finally focus on the problem of QTL detection in structured populations. I derive the asymptotic distribution of the Transmission Disequilibrium Test (TDT) and consequently obtain results about the type I error and the power of this test.
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Contributor : Simon Boitard Connect in order to contact the contributor
Submitted on : Thursday, February 22, 2007 - 12:38:12 PM
Last modification on : Wednesday, June 1, 2022 - 5:01:31 AM
Long-term archiving on: : Friday, September 21, 2012 - 11:41:01 AM


  • HAL Id : tel-00132675, version 1
  • PRODINRA : 251895


Simon Boitard. Cartographie de gènes à caractères quantitatifs par déséquilibre de liaison. Sciences du Vivant [q-bio]. Université Paul Sabatier - Toulouse III, 2006. Français. ⟨tel-00132675⟩



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