Implication de ghreline/obestatine, deux peptides issus du même précurseur, dans le contrôle de la sécrétion d'hormone de croissance et du comportement alimentaire.

Abstract : In this thesis we investigated relationships between ghrelin (GHR), growth hormone (GH) secretion and food intake (FI). We evidenced that: a) GHR secretion is pulsatile; b) GHR peaks are not correlated with GH ones, but are in close relation with FI episodes. However, utilization of a GHSR1a antagonist showed that endogenous GHR could modulate peak GH amplitude only and that GHR effects on FI involves either a GHSR1a with a different state of activation or another receptor; c) GHR plasma levels depend more on nutritional status than on fat mass and could be regulated by intestinal factors potentially implicated in the development of obesity; d) in anorexia nervosa, a transmission disequilibrium for the Leu72Met polymorphism of the prepro-ghrelin gene was observed with a better transmission in bingeing/purging than in restrictive probant.
Document type :
Theses
Neurons and Cognition [q-bio.NC]. Université Paris Sud - Paris XI, 2007. French


https://tel.archives-ouvertes.fr/tel-00129504
Contributor : Philippe Zizzari <>
Submitted on : Wednesday, February 7, 2007 - 6:16:14 PM
Last modification on : Wednesday, February 7, 2007 - 6:27:40 PM

Identifiers

  • HAL Id : tel-00129504, version 2

Collections

Citation

Philippe Zizzari. Implication de ghreline/obestatine, deux peptides issus du même précurseur, dans le contrôle de la sécrétion d'hormone de croissance et du comportement alimentaire.. Neurons and Cognition [q-bio.NC]. Université Paris Sud - Paris XI, 2007. French. <tel-00129504v2>

Export

Share

Metrics

Consultation de
la notice

145

Téléchargement du document

680