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Modulation de l'interaction intégrase/ADN du VIH-1 par des dérivés des styrylquinoléines et par la modification de nucléotides

Abstract : The HIV 1 integrase (IN) catalyses the insertion of the viral DNA into the infected cell's genome in two steps: the 3' processing and the strand transfer. We determined IN inhibitors binding mode (Styrylquinoline derivates) along the central domain' of the protein, in correlation with the proceeding mechanism found in vitro. To understand the effects of viral DNA analogues on the 3' processing activity and thus on the specific sequence interaction IN/DNA, we predicted the structure and the flexibility of nucleosides modified in 2 ' and of viral DNA LTR U5 extremity analogues.
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https://tel.archives-ouvertes.fr/tel-00129455
Contributor : Ens Cachan Bibliothèque <>
Submitted on : Wednesday, February 7, 2007 - 3:09:58 PM
Last modification on : Monday, February 15, 2021 - 10:38:30 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:49:31 PM

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  • HAL Id : tel-00129455, version 1

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Sophie Barbe. Modulation de l'interaction intégrase/ADN du VIH-1 par des dérivés des styrylquinoléines et par la modification de nucléotides. Biochimie [q-bio.BM]. École normale supérieure de Cachan - ENS Cachan, 2006. Français. ⟨tel-00129455⟩

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