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METABOLISME ENERGETIQUE MITOCHONDRIAL DANS
DES SITUATIONS DE PERTE DE POIDS

Abstract : Weight loss is frequently observed in clinical practice. When weight loss is unwanted
(undernutrition, hypercatabolism), whole body oxygen consumption is often increased, which
is paradoxical in face of anorexia. Our results show that food restriction induces a decrease in
liver mitochondrial respiration and respiratory chain activity, which is proportional to the
intensity of the food restriction, and may be mediated by leptin concentrations. Conversely, an
increase in liver basal proton leak and an impairment of in vivo oxidative phosphorylation in
the skeletal muscle are observed in rats treated with dexamethasone, which is a model of
acute undernutrition. These changes are likely to impact on resting metabolic rate, while
adaptation to food restriction probably limits ROS production.
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https://tel.archives-ouvertes.fr/tel-00128547
Contributor : Jean-François Dumas <>
Submitted on : Thursday, February 1, 2007 - 4:46:14 PM
Last modification on : Tuesday, May 7, 2019 - 6:30:07 PM
Long-term archiving on: : Friday, September 21, 2012 - 10:50:40 AM

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  • HAL Id : tel-00128547, version 1

Citation

Jean-François Dumas. METABOLISME ENERGETIQUE MITOCHONDRIAL DANS
DES SITUATIONS DE PERTE DE POIDS. Biochimie [q-bio.BM]. Université d'Angers, 2004. Français. ⟨tel-00128547⟩

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