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Synthèse et modification chimique de la surface de nanoparticules de maghémite à des fins d'applications biomédicales

Abstract : This work deals with the development of nanovectors containing superparamagnetic nanoparticles, intended for in vivo biomedical applications. The studies moved towards the optimization of the macromolecule coupling such as dextran and polyethyleneoxide derivatives
on the surface of magnetic nanoparticles in order to make them biocompatible. Surfaces of previously synthesized maghemite nanoparticles were modified by organofunctional silane coupling agents followed by a covalent grafting of the macromolecules. The nanovectors were then labeled by fluorescent probes to carry out double labeling in vitro tests (IRM, fluorescence) on human microglies (HEMC5).
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https://tel.archives-ouvertes.fr/tel-00128139
Contributor : Stéphane Toulin <>
Submitted on : Tuesday, January 30, 2007 - 6:38:55 PM
Last modification on : Wednesday, June 10, 2020 - 2:06:41 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:33:20 PM

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  • HAL Id : tel-00128139, version 1

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Stéphane Mornet. Synthèse et modification chimique de la surface de nanoparticules de maghémite à des fins d'applications biomédicales. Matériaux. Université Sciences et Technologies - Bordeaux I, 2002. Français. ⟨tel-00128139⟩

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