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Physiopathologie de l'inflammation cutanée : rôle de l'activation de l'immunité innée cutanée dans le développement de l'eczéma allergique de contact

Abstract : Haptens are endowed with pro-inflammatory and antigenic properties responsible for activation of both innate and acquired immunity leading to irritant and allergic contact dermatitis, respectively. Although it has been established that the frequency with which individuals develop allergic contact dermatitis directly correlates with the pro-inflammatory properties of haptens, the pathophysiological mechanisms linking irritancy and allergy are still not known precisely.
In the first part of the thesis, we show that the development and severity of allergic contact dermatitis depends on the ability of haptens to deliver non specific inflammatory signals during sensitization, leading to: i) irritant contact dermatitis, ii) recruitment of dendritic cell precursors into the skin, iii) migration rate of dendritic cells to the lymph nodes where T cell activation occurs and, iv) T cell recruitment into the skin. The second part of this work concerns the study of the role of Toll-like receptor-2 (TLR-2), an innate immune receptor, in the development of allergic contact dermatitis. We demonstrate that the absence of TLR-2 in sensitized mice leads to an exacerbate allergic contact dermatitis, indicating that TLR-2 is involved in the down-regulation of the skin inflammation. Collectively, our results demonstrate that irritancy conditions the magnitude of allergic responses. Therefore, molecules able to decrease the pro-inflammatory properties of haptens could be new preventive or curative treatments of both irritant and allergic contact dermatitis.
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https://tel.archives-ouvertes.fr/tel-00125271
Contributor : Marlene Bonneville <>
Submitted on : Thursday, January 18, 2007 - 5:10:43 PM
Last modification on : Friday, October 23, 2020 - 4:39:53 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:42:43 PM

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  • HAL Id : tel-00125271, version 1

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Marlene Bonneville. Physiopathologie de l'inflammation cutanée : rôle de l'activation de l'immunité innée cutanée dans le développement de l'eczéma allergique de contact. Immunologie. Université Claude Bernard - Lyon I, 2006. Français. ⟨tel-00125271⟩

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