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Algorithmes pour l'analyse de régions régulatrices dans le génome d'eucaryotes supérieurs

Abstract : The work presented in this thesis is oriented towards computational genome analysis. More precisely it focuses on gene expression and cis-regulatory elements. The cis-regulatory elements identification problem can be considered as a computational motif finding problem.

Finding such motifs is a challenging question due to the low specificity of these motifs. To answer this question, new kind of information need to been taken into account. This can be cross species conservation (comparative genomics), over-represented signals such as those shared by co-regulated genes, or even spatial conservation of binding site locations.

We have developed a method that searches for locally overrepresented regulatory motifs in a set of regulated genes. This method takes advantage of spatial conservation in the sequence and supports multiple species.
The method has been implemented in a software named TFM-Explorer. Promising results were obtained in a variety of examples in human, mouse, and rat genomes.
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https://tel.archives-ouvertes.fr/tel-00124471
Contributor : Matthieu Defrance <>
Submitted on : Monday, January 15, 2007 - 11:46:27 AM
Last modification on : Thursday, February 21, 2019 - 10:52:44 AM
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Matthieu Defrance. Algorithmes pour l'analyse de régions régulatrices dans le génome d'eucaryotes supérieurs. Autre [cs.OH]. Université des Sciences et Technologie de Lille - Lille I, 2006. Français. ⟨tel-00124471⟩

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