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RECEPTEURS ET MATERIAUX REDOX-ACTIFS POUR L'ACTIVATION ET LA SIGNALISATION D'INTERACTIONS MOLECULAIRES

Abstract : This work deals with the synthesis of calixphyrins-ferrocene, porphyrins-ferrocene and RAFT-ferrocene redox-active receptors and the study of their molecular electrochemical recognition properties.
Molecular receptors based on a porphyrinatozinc(II) directly linked to ferrocene have allowed a nitrogenous heterocycle' detection based on an original coordination-decoordination process centred on the porphyrin metal and an unprecedented selective amperometric halide anion detection.
Calixphyrins-ferrocene exhibit noticeable physico-chemical and structural features due to the tetrapyrrolic macrocycle conjugation interruption. These receptors have revealed original anions and cations complexation properties in solution and in solid state.
Finally, the ferrocene redox probe introduction onto a functionalized cyclodecapeptide (RAFT) allowed an efficient electrochemical detection of dihydrogenophosphate anion in solution and in heterogeneous phase. A cellular adhesion process study was led from RAFT-ferrocene SAMs functionalized by a specific endogenous integrin ligand, a protein overexpressed on numerous cancerous cells.
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https://tel.archives-ouvertes.fr/tel-00123612
Contributor : Charles Devillers <>
Submitted on : Wednesday, January 10, 2007 - 3:02:25 PM
Last modification on : Friday, November 6, 2020 - 4:04:07 AM
Long-term archiving on: : Thursday, April 8, 2010 - 1:28:42 PM

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  • HAL Id : tel-00123612, version 1

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Charles Devillers. RECEPTEURS ET MATERIAUX REDOX-ACTIFS POUR L'ACTIVATION ET LA SIGNALISATION D'INTERACTIONS MOLECULAIRES. Autre. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00123612⟩

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