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Méthodes optiques résolues en temps pour la tomographie de fluorescence dans les milieux diffusants

Abstract : Fluorescence diffuse optical imaging is an emerging diagnostic tool for localization and quantification of fluorescent probes in biological tissues. Time-resolved approaches are one of these techniques. An incident impulse of excitation light is sent to the medium and its temporal distribution is measured at the detection point. In this context, this thesis work deals with the study of light propagation models within the diffusion approximation. An experimental set up using a time-correlated single photon counting (TCSPC) detection system is presented. We provided methods for the characterization of the optical properties (A. Laidevant et al., Applied Optics, 45(19), 4756-4764) and the localization of a fluorescent inclusion (A. Laidevant et al., Applied Optics, in press) in a turbid medium, according to its geometry.
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https://tel.archives-ouvertes.fr/tel-00122185
Contributor : Aurélie Laidevant <>
Submitted on : Wednesday, December 27, 2006 - 5:35:21 PM
Last modification on : Friday, September 11, 2015 - 10:02:33 AM
Long-term archiving on: : Friday, September 21, 2012 - 9:51:36 AM

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  • HAL Id : tel-00122185, version 1

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Aurélie Laidevant. Méthodes optiques résolues en temps pour la tomographie de fluorescence dans les milieux diffusants. Biophysique [physics.bio-ph]. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00122185⟩

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