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ETUDE DES ALTERATIONS EPIGENETIQUES DANS LES CANCERS DES VOIES AERO-DIGESTIVES SUPERIEURES (VADS). IMPLICATION DANS LE DISGNOSTIC, LE SUIVI ET LE PRONOSTIC DES PATIENTS

Abstract : Studies in UADTs tumors biology have been performed to better understand the carcinogenesis and to find biomarkers that could have a prognostic value or an early detection benefit. In carcinogenesis of tumors of the UADTs, 2 main types of modifications have been identified at the cellular level: genetic and epigenetic alterations. Our work focused on methylation of tumor suppressor genes in tumors and saliva. Sixteen genes have thus been analyzed; we were then able to define a 6-gene methylation panel with a good correlation between results obtained in tumors and those obtained in saliva. Our results confirm the benefit of saliva analysis in cancer patients after treatment: persistence or reappearance of gene methylation precedes clinically evident tumor relapse. On the other hand, the presence of methylations in tumors has no prognostic value.
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https://tel.archives-ouvertes.fr/tel-00121319
Contributor : Christian Adrien Righini <>
Submitted on : Thursday, December 21, 2006 - 9:34:20 PM
Last modification on : Wednesday, December 23, 2020 - 9:53:35 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:23:44 PM

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  • HAL Id : tel-00121319, version 1

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Christian Adrien Righini. ETUDE DES ALTERATIONS EPIGENETIQUES DANS LES CANCERS DES VOIES AERO-DIGESTIVES SUPERIEURES (VADS). IMPLICATION DANS LE DISGNOSTIC, LE SUIVI ET LE PRONOSTIC DES PATIENTS. Biologie cellulaire. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00121319⟩

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