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Dosimétrie pour la radiothérapie en rayonnement synchrotron: calculs Monte-Carlo et gels radiosensibles

Abstract : High grade gliomas are extremely aggressive brain tumours. Specific techniques combining the presence of high atomic number elements within the tumour to an irradiation with a low x-rays (below 100 keV) beam from a synchrotron source were proposed. For the sake of clinical trials, the use of treatment planning system has to be foreseen as well as tailored dosimetry protocols. Objectives of this thesis work were (1) the development of a dose calculation tools based on Monte Carlo code for particles transport and (2) the implementation of an experimental method for the three dimensional verification of the dose delivered. The dosimetric tool is an interface between tomography images from patient or sample and the MCNPX general purpose code. Besides, dose distributions were measured through a radiosensitive polymer gel, providing acceptable results compared to calculations.
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https://tel.archives-ouvertes.fr/tel-00119516
Contributor : Caroline Boudou <>
Submitted on : Monday, December 11, 2006 - 9:41:02 AM
Last modification on : Friday, November 6, 2020 - 4:11:30 AM
Long-term archiving on: : Thursday, September 20, 2012 - 3:45:42 PM

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  • HAL Id : tel-00119516, version 1

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Caroline Boudou. Dosimétrie pour la radiothérapie en rayonnement synchrotron: calculs Monte-Carlo et gels radiosensibles. Physique [physics]. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00119516⟩

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