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Nouvelle approche multimodale et quantitative pour les études in vivo chez le petit animal : couplage de la $\beta$-MicroProbe aux techniques magnétiques et
développement de fantômes de rat et de souris voxelisés

Abstract : Since the last 15 years, animal models that mimic human disorders have become ubiquitous participants to understand biological mechanisms and human disorders and to evaluate new therapeutic approaches. The necessity to study these models in the course of
time has stimulated the development of instruments dedicated to in vivo small animal studies. To further understand physiopathological processes, the current challenge is to couple simultaneously several of these methods. Given this context, the combination of the magnetic and radioactive techniques remains an exciting challenge since it is still limited by strict technical constraints. Therefore we propose to couple the magnetic techniques with the radiosensitive Beta-MicroProbe, developed in the IPB group and which shown to be an elegant alternative to PET measurements. In this context, the thesis was dedicated to the study of the coupling feasibility from a physical point of view, by simulation and experimental characterizations. Then, the determination of a biological protocol was carried out on the basis of pharmacokinetic studies. The experiments have shown the possibility to use the probe for radioactive measurements under intense magnetic field simultaneously to anatomical images acquisitions. Simultaneously, we have sought to improve the
quantification of the radioactive signal using a voxelized phantom of a rat brain. Finally, the emergence of transgenic models led us to reproduce pharmacokinetic studies for the mouse and to develop voxelized mouse phantoms.
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Submitted on : Friday, November 24, 2006 - 10:44:54 AM
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Aurélie Desbrée. Nouvelle approche multimodale et quantitative pour les études in vivo chez le petit animal : couplage de la $\beta$-MicroProbe aux techniques magnétiques et
développement de fantômes de rat et de souris voxelisés. Biophysique [physics.bio-ph]. Université Paris-Diderot - Paris VII, 2005. Français. ⟨tel-00115911⟩

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