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Etude des Populations Lymphocytaires Exprimant des Récepteurs Spécifiques de Molécules HLA de Classe I au cours de l'Hépatite Virale C Chronique.

Abstract : We have analyzed the distribution and features of lymphocytes populations expressing HLA class I specific receptors (NKG2A and the KIRs CD158a,b and CD158b,j) in patients with persistent hepatitis C virus (HCV) infection. Such receptors are central for the regulation of natural killer (NK) cell responses and are found also on CD8+ T cells with activated/memory phenotype. We did not detect substantial accumulation of KIRs+CD8+ T cells in the blood or liver of chronic hepatitis C (cHC) patients. Of interest was the fact that the frequency of intrahepatic NKG2A+CD8+ T cells correlated positively with the severity of liver lesions. Finally, we found that KIRs+CD8+ and NKG2A+CD8+ T cells were differentially sensitive to the known pervasive influence that HCV can exert on CD8+ T cell phenotype. Altogether the results show that the analysis of HLA class I specific receptors expression reveal multiple alterations in the distribution of lymphocytes subsets in cHC patients.
keyword : Hepatitis NKR
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https://tel.archives-ouvertes.fr/tel-00114768
Contributor : Paula Bonorino <>
Submitted on : Friday, November 17, 2006 - 3:29:09 PM
Last modification on : Friday, September 11, 2015 - 9:58:13 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 7:43:03 PM

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  • HAL Id : tel-00114768, version 1

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Paula Bonorino. Etude des Populations Lymphocytaires Exprimant des Récepteurs Spécifiques de Molécules HLA de Classe I au cours de l'Hépatite Virale C Chronique.. Immunologie. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00114768⟩

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