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Conductivité de l'ADN : études à l'échelle de la molécule unique

Abstract : We present in this script the building and the characterization of a double optical trap setup that
enables single molecule manipulations over an opaque substrate, and force measurements up to 20 piconewtons.
This setup is first used to deposit a single DNA molecule on electrodes, and to explore its charge
transport properties. The interest of such a work is molecular electronics. We observe no current due to
the presence of the molecule. We conclude that there is a lower bound for the resistance of a 70 nm long
DNA molecule equal to 10^11 Ohm (in buffer conditions) or 10^13 Ohm (in dry conditions).
We also present force measurements on a molecular system of biological interest : the unzipping of a
short sequence of 23S rRNA from Escherichia coli. This preliminary work gives results that are in good
agreement with previous experiments from other teams.
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Contributor : Philippe Thomen <>
Submitted on : Friday, October 27, 2006 - 2:57:59 PM
Last modification on : Thursday, December 10, 2020 - 12:38:58 PM
Long-term archiving on: : Thursday, September 20, 2012 - 2:00:26 PM


  • HAL Id : tel-00110331, version 1


Olivier Legrand. Conductivité de l'ADN : études à l'échelle de la molécule unique. Biophysique []. Université Pierre et Marie Curie - Paris VI, 2005. Français. ⟨tel-00110331⟩



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