Skip to Main content Skip to Navigation
Theses

Modifications neurochimiques au sein des ganglions de la base et comportements moteurs associés lors d'une stimulation électrique du noyau subthalamique chez le rat hémiparkinsonien ou de la mise en place de la dénervation dopaminergique chez le singe

Abstract : High frequency stimulation (HFS) of the subthalamic nucleus (STN) treats the totality of Parkinson's disease motor symptoms which express only after 70 % of SNc dopaminergic neurons have degenerated. Mechanisms that allow to delay the appearance of motor symptoms or that underlie STN-HFS therapeutic efficiency in human remain unclear. Our work was focussed on freely moving awake animals.
In a first part, we analyzed the effects of STN-HFS on motor behaviour in intact and 6-OHDA rats and we investigated the correlation between these effects and extracellular glutamate and GABA levels assessed by intracerebral microdialysis in the SNr. These behavioural and neurochemical data coupled with pharmacological intranigral injections suggest that STN-HFS induced forelimb dyskinesia is mediated by glutamate and shedding light on the mechanisms of STN-HFS in PD.
In a second part, microdialysis have been performed in the same monkey during normal state, full expression of motor symptoms induced by MPTP and after recovery of these symptoms in order to correlate motor deficits and their recovery with changes of levels of neurotransmitters presents in two striatal territories: sensori-motor and limbic. We focussed our study on dopamine and its metabolites, Glutamate, GABA and serotonin levels Our results show that dopamine changes could play an important role in the compensatory mechanisms inducing recovery of normal motor functions.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-00110256
Contributor : Sabrina Boulet <>
Submitted on : Friday, October 27, 2006 - 10:31:07 AM
Last modification on : Friday, November 6, 2020 - 4:14:25 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 6:49:41 PM

Identifiers

  • HAL Id : tel-00110256, version 1

Collections

INSERM | UJF | UGA

Citation

Sabrina Boulet. Modifications neurochimiques au sein des ganglions de la base et comportements moteurs associés lors d'une stimulation électrique du noyau subthalamique chez le rat hémiparkinsonien ou de la mise en place de la dénervation dopaminergique chez le singe. Neurosciences [q-bio.NC]. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00110256⟩

Share

Metrics

Record views

382

Files downloads

1412