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Etude des effets et des mécanismes cardioprotecteurs de l'éthanol chez le rat

Abstract : Chronic and moderate ethanol drinking (CMED) is associated with low cardiac mortality and
results in increased plasma and cell levels of omega 3 fatty acids (ω3). Dietary ω3 are known
to reduce cardiac mortality in humans, induce cardioprotection in animals and incorporate in
membranes notably in mitochondria, an important target for cardioprotection. As ethanol and
ω3 seem to induce similar cardioprotective effects, our goal was to investigate whether a
CMED might mimic dietary ω3-induced mitochondrial lipid remodeling. These structural
modifications might modulate mitochondrial function and explain ethanol cardioprotection.
We showed that dietary supplementation with ω3 and CCME protect both myocardium
against ischemic/reperfusion in reducing infarct size on isolated perfused rat heart. After
checking dietary ω3-induced ω3 increase in mitochondrial membranes, we demonstrated that
CCME results in increased mitochondrial phosphatidylcholine and cardiolipin levels of ω3
but without disturbance on mitochondrial function. In plasma and cell membranes, CMED
resulted in higher ω3 and lower pro-apoptotic palmitate levels. In conclusion, CMED protects
myocardium against cell necrosis, increases cardioprotective fatty acids levels (ω3) and
decreases concentration of pro-apoptotic fatty acid (palmitate). CMED cardioprotection
likely results from the interaction between ethanol, ω3 and death cell pathways.
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https://tel.archives-ouvertes.fr/tel-00106391
Contributor : Annabelle Guiraud <>
Submitted on : Monday, December 4, 2006 - 4:46:44 PM
Last modification on : Friday, November 6, 2020 - 4:14:51 AM
Long-term archiving on: : Friday, September 24, 2010 - 11:56:42 AM

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  • HAL Id : tel-00106391, version 5

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Annabelle Guiraud. Etude des effets et des mécanismes cardioprotecteurs de l'éthanol chez le rat. Physiologie [q-bio.TO]. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00106391v5⟩

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