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Habilitation à diriger des recherches

Stimulations des voies auditives : nouveaux procédés

Abstract : I started my research by investigating the efficiency of a new method of brainstem auditory evoked potentials (BAEPs) monitoring during complete vestibular schwannoma resection with attempted hearing preservation. Auditory monitoring alerts the surgeon to ongoing changes in neural function, but the existing techniques have their limitations, suggesting the application of new methods. Combined BAEPs and direct auditory nerve monitoring will be performed in the future in attempt to enhance the chances of preventing irreversible hearing damage, and possibly improve the hearing outcome significantly. To achieve this goal, a multipoint flexible surface microelectrode for direct cortical recordings with a high spatiotemporal resolution has been fabricated and tested in animals. Recordings of cortical activities elicited by both acoustic and electrical stimulation on the cochlear nucleus have focused on the feasibility. Such electrodes are expected to enhance auditory neural coding understanding and provide new developments in human auditory monitoring and hearing rehabilitation, such as auditory brainstem implant (ABI). Access to the tonotopic organization of the cochlear nucleus with the existing ABI is limited. We have focused on basic prosperities, functional stimulation criteria in the auditory system, precise micro-stimulation, safety and efficacy of in-depth electrical stimulation of the cochlear nucleus using rat model. With collaboration with bioengineering department we have designed flexible multi-channel surface electrode that enables simultaneously recording from 64 different points on the surface of the auditory cortex after stimulating auditory periphery by sound or electrical stimuli with high spatial resolution. Using multi-channel electrode in vivo experiments revealed clearly differentiated evoked potentials in a spatio-temporal maps on the auditory cortex which varies by changing acoustic stimuli representing particular neuronal processing over the recording area. We have investigated whether sound and electrical stimulation has same physiological bases in the cochlear nucleus, inferior colliculus, and auditory cortex. We hope with this approach be able to examine long-term safety of implantation at the brainstem and effect of electrical stimulation on the other neuronal pathway at brainstem. Beside the basic research on this topic, I have also engaged in other research activities related to hearing and auditory system. We are trying to achieve a better understanding of the hearing performances in aural atresia patients. This topic has been studied in the ENT department of the University of Tokyo through electrophysiogical studies, using auditory brainstem evoked potentials and binaural interaction components in animals and in human, vestibular evoked myogenic potentials (acoustic and bone conducted stimuli). Behavioral studies were also conducted using bilateral bone-conducted stimuli paradigm. Our results suggest that the mature auditory brainstem has a plasticity potential to employ binaural cues later in life in patients who had an abnormal hearing experience.
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Habilitation à diriger des recherches
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https://tel.archives-ouvertes.fr/tel-00090315
Contributor : Sebastien Schmerber <>
Submitted on : Wednesday, August 30, 2006 - 7:31:17 AM
Last modification on : Friday, November 6, 2020 - 3:50:54 AM
Long-term archiving on: : Friday, May 13, 2011 - 9:05:18 PM

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  • HAL Id : tel-00090315, version 1

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Sebastien Schmerber. Stimulations des voies auditives : nouveaux procédés. Neurosciences [q-bio.NC]. Université Joseph-Fourier - Grenoble I, 2003. ⟨tel-00090315⟩

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