Abstract : The European regional policy tries to improve the level of the economic and social cohesion within Europe. However, the structural funds assigned to this policy modify economic as well as spatial structure of the regions. In addition, the reflexions engaged, in particular through the SDEC, aim at promoting a voluntarist policy of polycentric adjustment of European space. Thus we are led to consider both structuration and regional integration dynamics of this space. The spatial analysis is mobilized to account for the impact of the economic integration process as well as the effect of regional policy on the european spatial structuration. An inventive use of the most recent tools of spatial econometrics makes possible to appreciate and to quantify the concerned processes. More particulary, we seek to improve the modelization of the interactions between areas by building up gravitational spatial weights matrix which integrate relevant elements put forward by spatial theory.