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Rôles et fonctions des récepteurs neurologiques dans la réponse immunitaire

Abstract : During immune response such as thymic selection, contacts between cells were a major event dependent of synapse formation. Recently, molecules from neurological or neuro-muscular synapses were described to be express in immune cells and implicate in the regulation of contacts. We have investigated the pattern expression of neurological receptors on immune cells. Neuropilin-1 (Np-1), implicated in the growth cone collapse formation and regulation, was expressed in both dendritic cells (DC) and T cells. Similarly, Semaphorin-3A (Sema-3A), its natural ligand, was express and produces by immune cells. Interestingly, Np-1 was implicated in both DC-T cell and thymocyte-thymic epithelial cell synapse formation. Np-1 expression and regulation was dependent of TcR engagement or IL-7, especially for thymocytes. In contrast, Sema-3A was upregulated and secreted only after TcR engagement in both models. Sema-3A interferes with the TcR polarisation at the cell contacts trough the inhibition of actine polymerisation. The inhibition of endogenous Sema-3A using blocking monoclonal antibody, increased T cells proliferation. In addition, Sema-3A plays a major regulating role in thymocyte adhesion. Sema-3A decreases adhesion properties of thymocytes to extracellular matrix proteins such as laminine and fibronectin and induces thymocytes migration through a chemorepulsion phenomenon.
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https://tel.archives-ouvertes.fr/tel-00086126
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Submitted on : Tuesday, July 18, 2006 - 9:46:25 AM
Last modification on : Friday, March 27, 2020 - 2:23:41 AM
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  • HAL Id : tel-00086126, version 1

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Y. Lepelletier. Rôles et fonctions des récepteurs neurologiques dans la réponse immunitaire. Immunologie. Université Paris-Diderot - Paris VII, 2006. Français. ⟨tel-00086126⟩

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