Modélisation mathématique de la réponse lymphocytaire T spécifique à une infection virale

Abstract : T cell is one of the most important cells in specific immunity. In order to devise a tool for understanding and predicting some mechanisms of the immune system, a model for T cell response is proposed. The T lymphocyte activation by the recognition of a peptide carried by an antigen presenting cell is an essential step of this immune response. T cell activation was modelled by a system of ordinary differential equations of chemical kinetics type, representing the temporal evolution of the concentrations of different proteins of the lymphocyte (TCR/CD3, CD28, CD69, CD25, IL-2). In order to model a variable quantity of antigen in the organism, a model for virus proliferation was also written, similar to prey predator models. A system of ordinary differential equations thus obtains, involving a specific virus, its target cells (uninfected or infected), and cytotoxic T cell action. A coupling of these two models (T cell activation and virus proliferation) allows simulating the T cell specific response to a viral infection..
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Submitted on : Tuesday, July 11, 2006 - 5:39:16 PM
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Caroline Bidot. Modélisation mathématique de la réponse lymphocytaire T spécifique à une infection virale. Génie des procédés. Ecole Nationale Supérieure des Mines de Saint-Etienne, 2006. Français. ⟨tel-00085132⟩

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