J. Pawlotsky, Le virus de l'Hépatite C. Médecine/Sciences, pp.303-314, 2002.

T. Poynard, M. Yen, V. Ratziu, and C. Lai, Viral Hepatitis C. The Lancet, pp.2095-2100, 2003.

G. Lauer and W. B. , Hepatitis C Virus Infection, New England Journal of Medicine, vol.345, issue.1, pp.41-51, 2001.
DOI : 10.1056/NEJM200107053450107

S. Pol and H. Zylberberg, Formes cliniques et évolution de l'hépatite C, La Revue du praticien, vol.50, pp.1083-1088, 2000.

Q. Choo, G. Kuo, A. Weiner, L. Overby, D. Bradley et al., Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome, Science, vol.244, issue.4902, pp.359-362, 1989.
DOI : 10.1126/science.2523562

S. Rosenberg, Recent advances in the molecular biology of hepatitis C virus, Journal of Molecular Biology, vol.313, issue.3, pp.1083-1088, 2001.
DOI : 10.1006/jmbi.2001.5055

J. Koch and R. Bartenschlager, Determinants of Substrate Specificity in the NS3 Serine Proteinase of the Hepatitis C Virus, Virology, vol.237, issue.1, pp.78-88, 1997.
DOI : 10.1006/viro.1997.8760

B. Wolk, D. Sansonno, H. Krausslich, F. Dammacco, C. Rice et al., Subcellular Localization, Stability, and trans-Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines, Journal of Virology, vol.74, issue.5, pp.2293-2304, 2000.
DOI : 10.1128/JVI.74.5.2293-2304.2000

-. Steinkuhler, Activity of purified Hepatitis C virus protease NS3 on peptide substrates, J Virol, vol.70, pp.6694-700, 1996.

L. Hedsrom, L. Szilagyi, and W. Rutter, Converting trypsin to chymotrypsin: the role of surface loops, Science, vol.255, issue.5049, pp.1249-1253, 1992.
DOI : 10.1126/science.1546324

T. Adachi and Z. Hostomska, The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site. Cell, pp.331-342, 1996.

J. Kim, K. Morgenstern, J. Griffith, M. Dwyer, J. Thomson et al., Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding, Structure, vol.6, issue.1, pp.89-100, 1998.
DOI : 10.1016/S0969-2126(98)00010-0

J. Thomson, Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide, Cell, vol.87, pp.343-355, 1996.

D. Mercer, D. Schiller, J. Elliott, D. Douglas, C. Hao et al., Hepatitis C virus replication in mice with chimeric human livers, Nature Medicine, vol.7, issue.8, pp.927-933, 2001.
DOI : 10.1038/90968

B. Lindenbach, P. Meuleman, A. Ploss, T. Vanwolleghem, A. Syder et al., Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro, Proceedings of the National Academy of Sciences, vol.308, issue.2, pp.3805-3809, 2006.
DOI : 10.1016/S0006-291X(03)01388-3

V. Racanelli and R. B. , Hepatitis C virus infection: when silence is deception, Trends in Immunology, vol.24, issue.8, pp.456-464, 2003.
DOI : 10.1016/S1471-4906(03)00178-9

C. Neumann-haefelin, H. Blum, F. Chisari, and R. Thimme, T cell response in hepatitis C virus infection, Journal of Clinical Virology, vol.32, issue.2, pp.75-85, 2005.
DOI : 10.1016/j.jcv.2004.05.008

J. Sun, K. Li, M. Shata, and C. Ts, The immunologic basis for hepatitis C infection, Current Opinion in Gastroenterology, vol.20, issue.6, pp.598-602, 2004.
DOI : 10.1097/00001574-200411000-00016

J. Zarski and C. Souvignet, Physiopathology of HCV infection, Gastroenterol.Clini. Biol, vol.26, pp.154-162, 2002.

Y. Hahn, Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?, Current Opinion in Immunology, vol.15, issue.4, pp.443-449, 2003.
DOI : 10.1016/S0952-7915(03)00076-1

A. Eisen-vandervelde, Z. Yao, and Y. Hahn, The molecular basis of HCV-mediated immune dysregulation, Clinical Immunology, vol.111, issue.1, pp.16-21, 2004.
DOI : 10.1016/j.clim.2003.12.003

. Obermayer-straub and M. Manns, Hepatitis C and D, Retroviruses and Autoimmune Manifestations, Journal of Autoimmunity, vol.16, issue.3, pp.275-285, 2001.
DOI : 10.1006/jaut.2000.0488

P. Cacoub, C. Renou, E. Rosenthal, P. Cohen, I. Loury et al., Extrahepatic Manifestations Associated with Hepatitis C Virus Infection: A Prospective Multicenter Study of 321 Patients, Medicine, vol.79, issue.1, pp.47-56, 2005.
DOI : 10.1097/00005792-200001000-00005

M. Trendelenburg and J. Schifferli, Cryoglobulins in chronic hepatitis C virus infection, Clinical and Experimental Immunology, vol.45, issue.2, pp.153-155, 2003.
DOI : 10.1182/blood-2002-10-3162

E. Zuckermann, G. Slobodin, A. Kessel, E. Sabo, D. Yeshurin et al., Peripheral B-cell CD5 expansion and CD81 overexpression and their association with -79, 2002.

C. Strassburg, A. Vogel, and M. Manns, Autoimmunity and hepatitis C, Autoimmunity Reviews, vol.2, issue.6, pp.322-331, 2003.
DOI : 10.1016/S1568-9972(03)00036-3

S. Vento and F. Cainelli, Is there a role for viruses in triggering autoimmune hepatitis?, Autoimmunity Reviews, vol.3, issue.1, pp.61-69, 2004.
DOI : 10.1016/S1568-9972(03)00053-3

N. Kerkar, K. Choudhuri, Y. Ma, A. Mahmoud, D. Bogdanos et al., Cytochrome P4502D6193-212: A New Immunodominant Epitope and Target of Virus/Self Cross-Reactivity in Liver Kidney Microsomal Autoantibody Type 1-Positive Liver Disease, The Journal of Immunology, vol.170, issue.3, pp.1481-1489, 2003.
DOI : 10.4049/jimmunol.170.3.1481

K. Zachou, E. Rigopoulou, and G. Dalekos, Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease, J. Autoimmune Dis, vol.1, pp.1-17, 2004.

G. Gregorio, K. Choudhuri, Y. Ma, P. Pensati, R. Iorio et al., Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection, Clinical and Experimental Immunology, vol.154, issue.3, pp.404-413, 2003.
DOI : 10.1093/emboj/19.6.1195

A. Vogel, M. Manns, and C. Strassburg, Autoimmunity and viruses, Clinics in Liver Disease, vol.6, issue.3, pp.451-465, 2002.
DOI : 10.1016/S1089-3261(02)00024-7

D. Rosa, F. Barnaba, and V. , Persisting viruses and chronic inflammation: understanding their relation to autoimmunity, Immunological Reviews, vol.248, issue.1, pp.17-27, 1998.
DOI : 10.1084/jem.186.12.2039

N. Rose, Infection, mimics, and autoimmune disease, Journal of Clinical Investigation, vol.107, issue.8, pp.943-944, 2001.
DOI : 10.1172/JCI12673

E. Liberman, L. Fong, . Selbym, Q. Choo, L. Cousens et al., Activation of the grp78 and grp94 Promoters by Hepatitis C Virus Envelope Protein, 1999.

Y. Kuramitsu and K. Nakamura, Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma, Expert Review of Proteomics, vol.2, issue.4, pp.589-601, 2005.
DOI : 10.1586/14789450.2.4.589

B. Wölk, D. Sansonno, H. Kraüsslich, F. Dammacco, C. Rice et al., Subcellular Localization, Stability, and trans-Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines, Journal of Virology, vol.74, issue.5, pp.12293-2304, 2000.
DOI : 10.1128/JVI.74.5.2293-2304.2000

P. Srivastava, Heat shock proteins and immune response: methods to madness, Methods, vol.32, issue.1, pp.1-2, 2004.
DOI : 10.1016/S1046-2023(03)00178-6

P. Srivastava, ROLES OF HEAT-SHOCK PROTEINS IN INNATE AND ADAPTIVE IMMUNITY, Nature Reviews Immunology, vol.166, issue.3, pp.185-194, 2002.
DOI : 10.1002/(SICI)1521-4141(199803)28:03<1016::AID-IMMU1016>3.0.CO;2-G

A. Pockley, Heat shock proteins as regulators of the immune response, The Lancet, vol.362, issue.9382, pp.469-476, 2003.
DOI : 10.1016/S0140-6736(03)14075-5

K. Mandal, . Jahangiri, and Q. Xu, Autoimmunity to heat shock proteins in atherosclerosis, Autoimmunity Reviews, vol.3, issue.2, pp.31-37, 2004.
DOI : 10.1016/S1568-9972(03)00088-0

J. Gaston, Heat shock proteins and innate immunity, Clinical & Experimental Immunology, vol.165, issue.1, pp.1-3, 2002.
DOI : 10.1046/j.1365-2249.2002.01759.x

M. Tsan and B. Gao, Cytokine function of heat shock proteins, AJP: Cell Physiology, vol.286, issue.4, pp.739-744, 2004.
DOI : 10.1152/ajpcell.00364.2003

A. Asea, Stress Proteins and Initiation of Immune Response: Chaperokine activity of Hsp72, Exerc. Immunol. Rev, vol.11, pp.34-45, 2005.

N. Hilf, H. Singh-jasuja, and H. Schild, The heat shock protein Gp96 links innate and specific immunity, International Journal of Hyperthermia, vol.18, issue.6, pp.521-533, 2002.
DOI : 10.1080/02656730210166177

C. Gullo and G. Teoh, Heat shock proteins: to present or not, that is the question, Immunology Letters, vol.94, issue.1-2, pp.1-10, 2004.
DOI : 10.1016/j.imlet.2004.04.002

G. Nardai, E. Végh, Z. Prohaszka, and P. Csermely, Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks, Trends in Immunology, vol.27, issue.2, pp.74-79, 2003.
DOI : 10.1016/j.it.2005.11.009

S. Sastry and N. Linderoth, Molecular Mechanisms of Peptide Loading by the Tumor Rejection Antigen/Heat Shock Chaperone gp96 (GRP94), Journal of Biological Chemistry, vol.274, issue.17, pp.12023-12035, 1999.
DOI : 10.1074/jbc.274.17.12023

R. Binder, R. Vatner, and P. Srivastava, The heat-shock protein receptors: some answers and more questions, Tissue Antigens, vol.165, issue.4, pp.442-451, 2004.
DOI : 10.1016/j.bbrc.2004.03.160

A. Pockley, Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?, Expert Reviews in Molecular Medicine, vol.3, issue.23, pp.1-20, 2001.
DOI : 10.1017/S1462399401003556

S. Todryk, M. Gough, and A. Pockley, Facets of heat shock protein 70 show immunotherapeutic potential, Immunology, vol.66, issue.1, pp.1-9, 2003.
DOI : 10.1038/15200

A. Michils, D. Dutry, Z. De-beyl, V. Remmelink, M. Maertelaer et al., Peripheral Blood Mononuclear Cell Proliferation to Heat Shock Protein???70 Derived from Autologous Lung Carcinoma, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.5, pp.749-753, 2002.
DOI : 10.1164/rccm.200202-126OC

Y. Wang, T. Whittall, E. Mcgovan, J. Younson, C. Kelly et al., Identification of Stimulating and Inhibitory Epitopes within the Heat Shock Protein 70 Molecule That Modulate Cytokine Production and Maturation of Dendritic Cells, The Journal of Immunology, vol.174, issue.6, pp.3306-3316, 2005.
DOI : 10.4049/jimmunol.174.6.3306

J. Radons and G. Multhoff, Immunostimulatory functions of membrane-bound and exported heat shock protein 70, Exerc. Immunol. Rev, vol.11, pp.17-33, 2005.

J. Baker-lepain, R. Reed, and C. Nicchitta, ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection, Current Opinion in Immunology, vol.15, issue.1, pp.89-94, 2003.
DOI : 10.1016/S0952791502000067

J. Koch, J. Koch, V. Lohmann, U. Herian, and R. Bartenschlager, In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor. Virology, pp.54-66, 1996.

C. Drouet, L. Bouillet, F. Csopaki, and M. Colomb, Hepatitis C virus NS3 serine protease interacts with the serpin C1 inhibitor, FEBS Letters, vol.27, issue.3, pp.415-418, 1999.
DOI : 10.1016/S0014-5793(99)01194-1

D. Thibeault, C. Bousquet, R. Gingras, L. Lagace, M. R. White et al., Sensitivity of NS3 Serine Proteases from Hepatitis C Virus Genotypes 2 and 3 to the Inhibitor BILN 2061, Journal of Virology, vol.78, issue.14, pp.7352-7359, 2004.
DOI : 10.1128/JVI.78.14.7352-7359.2004

C. Vitali, S. Bombardieri, R. Jonsson, H. Moutsopoulos, and E. Alexander, Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group, Annals of the Rheumatic Diseases, vol.61, issue.6, pp.554-562, 2002.
DOI : 10.1136/ard.61.6.554

E. Tan, A. Cohen, and J. Fries, The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis & Rheumatism, vol.31, issue.11, pp.1271-1278, 1982.
DOI : 10.1002/art.1780251101

G. Barba, F. Harper, T. Harada, M. Kohara, S. Goulinet et al., Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets, Proceedings of the National Academy of Sciences, vol.15, issue.8, pp.1200-1205, 1997.
DOI : 10.1089/jir.1995.15.705

G. Vinci, N. Lynch, C. Duponchel, T. Lebastard, G. Milon et al., In Vivo Biosynthesis of Endogenous and of Human C1 Inhibitor in Transgenic Mice: Tissue Distribution and Colocalization of Their Expression, The Journal of Immunology, vol.169, issue.10, pp.5948-54, 2002.
DOI : 10.4049/jimmunol.169.10.5948

R. Njemini, C. Demanet, and T. Mets, Determination of intracellular heat shock protein 70 using a newly developed cell lysate immunometric assay, Journal of Immunological Methods, vol.274, issue.1-2, pp.271-279, 1997.
DOI : 10.1016/S0022-1759(03)00004-8

Y. Maehara, E. Oki, T. Abe, E. Tokunaga, K. Shibahara et al., Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer. Oncology, pp.144-51, 2000.

P. Peng, A. Menoret, and P. Srivastava, Purification of immunogenic heat shock protein 70???peptide complexes by ADP-affinity chromatography, Journal of Immunological Methods, vol.204, issue.1, pp.13-21, 1997.
DOI : 10.1016/S0022-1759(97)00017-3

A. Menoret, Purification of recombinant and endogenous HSP70s. Methods, pp.7-12, 2004.

A. Rada, P. Tonino, G. Anselmi, and M. Strauss, Is hypothermia a stress condition in HepG2 cells?, Tissue and Cell, vol.37, issue.1, pp.59-65, 2005.
DOI : 10.1016/j.tice.2004.10.003

X. Zhu, C. Li, Z. Lang, G. Gao, and P. Tien, Significant correlation between expression level of HSP gp 96 and progression of hepatitis B virus induced diseases, World J. Gastroenterol, vol.10, pp.1141-1145, 2004.

S. Lim, S. Park, J. Yoo, Y. Park, H. Kim et al., Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules, World Journal of Gastroenterology, vol.11, issue.14, pp.2072-2079, 2005.
DOI : 10.3748/wjg.v11.i14.2072

C. Torronteguy, A. Frasson, F. Zerwes, E. Winnikov, V. Da-silva et al., Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors, Cell Stress & Chaperones, vol.5, issue.1, pp.34-43, 2006.
DOI : 10.1379/CSC-159R.1

K. Yamazaki, T. Nguyen, and E. Podack, Cutting Edge: Tumor Secreted Heat Shock-Fusion Protein Elicits CD8 Cells for Rejection, J. Immunol, vol.163, pp.5178-5182, 1999.

M. Takashima, Y. Kuramitsu, Y. Yokoyama, N. Lizuza, T. Toda et al., Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma, PROTEOMICS, vol.3, issue.12, pp.2497-2493, 2003.
DOI : 10.1002/pmic.200300621

A. Pockley, J. Shepard, and J. Corton, Detection of heat shock protein 70 (HSP70) and anti-HSP70 antibodies in the serum of normal individuals, Immunological Investigations, vol.278, issue.6, pp.367-377, 1998.
DOI : 10.1172/JCI117801

R. Njemini, M. Lambert, C. Demanet, and T. Mets, Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging, Biogerontology, vol.5, issue.1, pp.31-38, 2004.
DOI : 10.1023/B:BGEN.0000017684.15626.29

R. Njemini, M. Lambert, C. Demanet, and T. Mets, Elevated Serum Heat-Shock Protein 70 Levels in Patients with Acute Infection: Use of an Optimized Enzyme-Linked Immunosorbent Assay, Scandinavian Journal of Immunology, vol.58, issue.6, pp.664-669, 2003.
DOI : 10.1161/hc0602.103617

B. Ripley, D. Isenberg, and D. Latchman, Elevated Levels of the 90kDa Heat Shock Protein (hsp90) in SLE Correlate with Levels of IL-6 and Autoantibodies to hsp90, Journal of Autoimmunity, vol.17, issue.4, pp.341-346, 2001.
DOI : 10.1006/jaut.2001.0549

R. Wallin, A. Lundqvist, S. Moré, A. Von-bonin, R. Kiessling et al., Heat-shock proteins as activators of the innate immune system. Traffic, pp.690-697, 2001.

J. Koxsis, Z. Prohaszka, A. Biró, G. Füst, and D. Bánhegyi, Elevated level of antibodies against 70kDa heat shock proteins in the sera of patients with HIV infection, J. Med. Virol, vol.71, pp.480-482, 2003.

Y. Fukuda, H. Yotsuyanagi, S. Ooka, T. Sekine, J. Koike et al., Identification of a new autoantibody in patients with chronic hepatitis, Human Immunology, vol.65, issue.12, pp.1530-1538, 2004.
DOI : 10.1016/j.humimm.2004.08.186

R. Shingai, T. Maeda, S. Onishi, and Y. Yamamoto, Autonatibody against 70 kD heat shock protein in patients with autoimmune liver diseases, Journal of Hepatology, vol.23, issue.4, pp.382-390, 1995.
DOI : 10.1016/0168-8278(95)80195-2

H. Direskeneli and G. Saruhan-direskeneli, Review: The Role of Heat Shock Proteins in Behçet's Disease, Clin. Exp. Rheumatol, vol.21, pp.44-48, 2003.

P. Yung, G. Le, T. Roord, S. Prakken, B. Albani et al., Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA), Inflammation Research, vol.52, issue.11, pp.443-451, 2003.
DOI : 10.1007/s00011-003-1204-6

L. Munari, S. Charchat, L. Rodrigues, A. Von-muhlen, C. Bau et al., An ELISA serum assay for autoantibodies to HSP70 in immune-mediated hearing loss, Journal of Immunological Methods, vol.283, issue.1-2, pp.155-161, 2000.
DOI : 10.1016/j.jim.2003.09.008

S. Chauhan, N. Tripathy, N. Sinha, M. Singh, and S. Nityanand, Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu's arteritis, Clinical and Experimental Immunology, vol.134, issue.3, pp.547-553, 2004.
DOI : 10.1016/0167-5699(90)90050-J

M. De-smet and A. Ramadan, Circulating antibodies to inducible heat shock protein 70 in patients with uveitis, Ocular Immunology and Inflammation, vol.12, issue.2, pp.85-92, 2001.
DOI : 10.1076/ocii.

H. Qin, J. Mahon, M. Atkinson, P. Chaturvedi, E. Lee-chan et al., Type 1 diabetes alters anti-hsp90 autoantibody isotype, Journal of Autoimmunity, vol.20, issue.3, pp.237-245, 2003.
DOI : 10.1016/S0896-8411(03)00035-0

S. Conroy, G. Faulds, W. Williams, D. Latchman, and D. Isenberg, DETECTION OF AUTOANTIBODIES TO THE 90 kDa HEAD SHOCK PROTEIN IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER AUTOIMMUNE DISEASES, Rheumatology, vol.33, issue.10, pp.923-929, 1994.
DOI : 10.1093/rheumatology/33.10.923

A. Kenderov, D. Minkova, D. Mihailova, N. Giltiay, S. Kyurkchiev et al., Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies, Clinical & Experimental Immunology, vol.28, issue.1, pp.169-176, 2002.
DOI : 10.1046/j.1365-2249.2002.01887.x

M. Dieudé, J. Senécal, and R. Y. , Induction of endothelial cell apoptosis by heat-shock protein 60-reactive antibodies from anti-endothelial cell autoantibody-positive systemic lupus erythematosus patients, Arthritis & Rheumatism, vol.44, issue.10, pp.3221-3231, 2004.
DOI : 10.1002/art.20564

R. Villalobos-hurtado, S. Sanchez-rodriguez, E. Avalos-diaz, R. Herrera-esparza, and R. Herrera-esparza, Possible role of Hsp70 in autoantigens shuttling to dermo-epidermal junction in systemic lupus erythematosus, Reumatismo, vol.55, issue.3, pp.155-158, 2003.
DOI : 10.4081/reumatismo.2003.155

D. Vassilopoulos and L. Calabrese, Extrahepatic immunological complications of hepatitis C virus infection, AIDS, vol.19, issue.Suppl 3, pp.123-127, 2005.
DOI : 10.1097/01.aids.0000192080.56808.38

M. Ramos-casals, L. Jara, F. Medina, J. Rosas, J. Calvo-alen et al., Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): patterns of clinical and immunological expression in 180 cases, Journal of Internal Medicine, vol.27, issue.6, pp.549-557, 2005.
DOI : 10.1097/00004836-200404000-00011

T. Stroffolini, G. Colloredo, G. Gaeta, A. Sonzogni, S. Angeletti et al., Does an 'autoimmune' profile affect the clinical profile of chronic hepatitis C? An Italian multicentre survey, Journal of Viral Hepatitis, vol.108, issue.3, pp.257-262, 2004.
DOI : 10.1126/science.282.5390.938

P. Muratori, L. Muratori, T. Stroffolini, G. Pappas, P. Terlizzi et al., Prevalence of non-organ specific autoantibodies in HCV-infected subjects in the general population, Clinical and Experimental Immunology, vol.68, issue.1, pp.118-121, 2003.
DOI : 10.1016/S0047-6374(96)01845-3

H. Wasmuth, C. Stolte, A. Geier, C. Dietrich, C. Gartung et al., The presence of non-organ-specific autoantibodies is associated with a negative response to combination therapy with interferon and ribavirin for chronic hepatitis C, BMC Infectious Diseases, vol.6, issue.1, pp.1-11, 2004.
DOI : 10.1016/S1089-3261(02)00031-4

D. Sène, N. Limal, and C. P. , Hepatitis C Virus-Associated Extrahepatic Manifestations: A Review, Metabolic Brain Disease, vol.19, issue.3/4, pp.357-381, 2004.
DOI : 10.1023/B:MEBR.0000043982.17294.9b

J. Goral, S. Shenoy, T. Mohanakumar, C. Jr, and J. , -host disease in peripheral blood stem cell transplant recipients, Clinical & Experimental Immunology, vol.179, issue.3, pp.553-559, 2002.
DOI : 10.1046/j.1365-2249.2002.01770.x

URL : https://hal.archives-ouvertes.fr/tel-01184906

P. Muratori, L. Muratori, M. Guidi, A. Granito, M. Susca et al., Clinical Impact of Non--Organ-Specific Autoantibodies on the Response to Combined Antiviral Treatment in Patients with Hepatitis C, Clinical Infectious Diseases, vol.40, issue.4, pp.501-507, 2005.
DOI : 10.1086/427285

K. Omagari, K. Ohba, Y. Kadokawa, K. Hayashida, H. Isomoto et al., Anti-extractable Nuclear Antigens (ENA) Antibodies in Patients with Chronic Hepatitis C before and after Treatment with Interferon, Autoimmunity, vol.128, issue.5, pp.269-273, 2003.
DOI : 10.1080/0891693031000152660

D. Rosa, F. Pucillo, L. Coviello, R. Pirro, M. Fiaschetti et al., Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia, Human Immunology, vol.63, issue.9, pp.751-757, 2002.
DOI : 10.1016/S0198-8859(02)00423-8

J. Quiroga, M. Pardo, S. Navas, J. Martin, and V. Carreno, Patterns of Immune Responses to the Host-Encoded GOR and Hepatitis C Virus Core-Derived Epitopes with Relation to Hepatitis C Viremia, Genotypes, and Liver Disease Severity, Journal of Infectious Diseases, vol.173, issue.2, pp.300-305, 1996.
DOI : 10.1093/infdis/173.2.300

J. Feld and J. Hoofnagle, Mechanism of action of interferon and ribavirin in treatment of hepatitis C, Nature, vol.128, issue.7053, pp.967-972, 2005.
DOI : 10.1126/science.1114016

A. Garrido, J. Lepe, F. Guerrero, and S. Palomo, Serologic response against hepatitis C virus as a predicitive factor for the treatment with interferon, Enferm Infec Microbiol Clin, vol.18, pp.512-515, 2000.

L. Santomenna, C. , and A. , Induction of Cellular hsp70 Expression by Human Cytomegalovirus, J. Virol, vol.64, pp.2033-2040, 1990.

Z. Wainberg, M. Oliveira, Y. Tao, and B. Brenner, Modulation of Stress Protein (hsp27 and hsp70) Expression in CD4+ Lymphocytic Cells Following Acute Infection with Human Immunodeficiency Virus Type-1. Virology, pp.364-373, 1997.

M. Kotsiopriftis, J. Tanner, and C. Alfieri, Heat Shock Protein 90 Expression in Epstein-Barr Virus-Infected B Cells Promotes ???? T-Cell Proliferation In Vitro, Journal of Virology, vol.79, issue.11, pp.7255-7261, 2005.
DOI : 10.1128/JVI.79.11.7255-7261.2005

L. Waxman, M. Whitney, B. Pollok, L. Kuo, and P. Darke, Host cell factor requirement for hepatitis C virus enzyme maturation, Proceedings of the National Academy of Sciences, vol.18, issue.12, pp.13931-13935, 2001.
DOI : 10.1038/82422

Y. Choi, Y. Tan, S. Lim, W. Hong, and P. Goh, Proteomic approach identifies HSP27 as an interacting partner of the hepatitis C virus NS5A protein, Biochemical and Biophysical Research Communications, vol.318, issue.2, pp.514-519, 2004.
DOI : 10.1016/j.bbrc.2004.04.052

A. Federico, C. Tuccillo, F. Terracciano, D. Allessio, C. Galdiero et al., Heat shock protein 27 expression in patients with chronic liver damage, Immunobiology, vol.209, issue.10, pp.729-735, 2004.
DOI : 10.1016/j.imbio.2004.12.006

P. Eggleton, Stress protein-polypeptide complexes acting as autoimmune triggers, Clinical and Experimental Immunology, vol.132, issue.1, pp.6-8, 2003.
DOI : 10.1046/j.1365-3083.1999.00542.x

A. Purcell, A. Todd, G. Kinoshita, T. Lynch, C. Keech et al., Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?, Clinical and Experimental Immunology, vol.161, issue.2, pp.193-200, 2003.
DOI : 10.1038/nature00811

E. Staikou, J. Routsias, A. Makri, A. Terzoglou, M. Sakarellos-daitsiotis et al., Calreticulin binds preferentially with B cell linear epitopes of Ro60 kD autoantigen, enhancing recognition by anti-Ro60 kD autoantibodies, Clinical and Experimental Immunology, vol.177, issue.5, pp.143-150, 2003.
DOI : 10.1093/intimm/12.11.1539

I. Auger and J. Roudier, Interaction Between HSP73 and HLA-DRB1*0401: Implications for the Development of Rheumatoid Arthritis, Immunologic Research, vol.31, issue.3, pp.261-266, 2005.
DOI : 10.1385/IR:31:3:261

J. Zabrecky and W. Sawlivich, Purification of the heat shock protein, gp96, from natural sources. Methods, pp.3-6, 2004.

D. Przepiorka and P. Srivastava, Heat shock protein???peptide complexes as immunotherapy for human cancer, Molecular Medicine Today, vol.4, issue.11, pp.478-484, 1998.
DOI : 10.1016/S1357-4310(98)01345-8

T. Nieland, A. Tan, M. Monnee-van-muijen, F. Koning, A. Kruisbeek et al., Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94., Proc. Natl. Acad. Sci.USA-Immunology, pp.6135-6139, 1996.
DOI : 10.1073/pnas.93.12.6135

?. Meng, S. Song, J. Rao, Z. Tien, P. Gao et al., Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides, Journal of Immunological Methods, vol.264, issue.1-2, pp.29-35, 2002.
DOI : 10.1016/S0022-1759(02)00093-5

P. Peng, A. Ménoret, and P. Srivastava, Purification of immunogenic heat shock protein 70???peptide complexes by ADP-affinity chromatography, Journal of Immunological Methods, vol.204, issue.1, pp.13-21, 1997.
DOI : 10.1016/S0022-1759(97)00017-3

D. Vanaja, M. Grossman, E. Celis, and C. Young, Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14- prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells, Cancer Res, vol.60, pp.4714-4718, 2000.

S. Meng, T. Gao, G. Gao, and T. Po, HBV-specific peptide associated with heat-shock protein gp96, The Lancet, vol.357, issue.9255, pp.528-529, 2001.
DOI : 10.1016/S0140-6736(00)04050-2

G. Bolt, The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression, Archives of Virology, vol.146, issue.11, pp.2055-2068, 2001.
DOI : 10.1007/s007050170020

Z. Xu, G. Jensen, and T. Yen, Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum, J Virol, vol.71, pp.7387-7392, 1997.

S. Laquerre, D. Anderson, R. Argnni, and J. Gloriosco, Herpès simplex virus type 1 glycoprotein B requires a cysteine residue at position 633 for folding, processing, and incorporation into mature infectious virus particles, J Virol, vol.72, pp.4940-4949, 1998.

A. Mirazimi and L. Svensson, ATP Is Required for Correct Folding and Disulfide Bond Formation of Rotavirus VP7, Journal of Virology, vol.74, issue.17, pp.8048-8052, 2000.
DOI : 10.1128/JVI.74.17.8048-8052.2000

A. Xu, A. Bellamy, and J. Taylor, BiP (GRP78) and endoplasmin (GRP94) are induced following rotavirus infection and bind transiently to an endoplasmic reticulumlocalized virion component, J Virol, vol.72, pp.9865-9872, 2000.

M. Grossmann, B. Madden, F. Gao, Y. Pang, J. Carpenter et al., Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo, Experimental Cell Research, vol.297, issue.1, pp.108-117, 2004.
DOI : 10.1016/j.yexcr.2004.02.030

D. Sengupta, P. Norris, T. Suscovich, M. Hassan-zahraee, H. Moffett et al., Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II, The Journal of Immunology, vol.173, issue.3, pp.1987-1993, 2004.
DOI : 10.4049/jimmunol.173.3.1987

S. Somersan, M. Larsson, J. Fonteneau, S. Basu, P. Srivastava et al., Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells, The Journal of Immunology, vol.167, issue.9, pp.4844-4852, 2001.
DOI : 10.4049/jimmunol.167.9.4844

E. Noessner, R. Gastpar, V. Milani, A. Brandl, P. Hutzler et al., Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells, The Journal of Immunology, vol.169, issue.10, pp.5424-5432, 2001.
DOI : 10.4049/jimmunol.169.10.5424

H. Udono and P. Srivastava, Comparison of Tumor-Specific Immunogeniticities of Stress-Induced Proteins gp96, hsp 90, and hsp70, J. Immunol, vol.152, pp.5398-5403, 1994.

R. Kammerer, D. Stober, P. Riedl, C. Oehninger, R. Schirmbeck et al., Noncovalent Association with Stress Protein Facilitates Cross-Priming of CD8+ T Cells to Tumor Cell Antigens by Dendritic Cells, The Journal of Immunology, vol.168, issue.1, pp.108-117, 2002.
DOI : 10.4049/jimmunol.168.1.108

N. Blachere, Z. Li, R. Chandawarkar, R. Suto, N. Jaikaria et al., Heat Shock Protein???Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity, The Journal of Experimental Medicine, vol.33, issue.8, pp.1315-1322, 1997.
DOI : 10.1002/eji.1830270418

Z. Li, In vitro reconstitution of heat shock protein-peptide complexes for generating peptide-specific vaccines and infectious diseases. Methods, pp.25-28, 2004.

H. Udono, T. Saito, M. Ogawa, and Y. Yui, HSP-antigen fusion and their use for immunization. Methods, pp.21-24, 2004.

D. Thibeault, C. Bousquet, R. Gingras, L. Lagacé, M. R. White et al., Sensitivity of NS3 Serine Proteases from Hepatitis C Virus Genotypes 2 and 3 to the Inhibitor BILN 2061, Journal of Virology, vol.78, issue.14, pp.7352-7359, 2004.
DOI : 10.1128/JVI.78.14.7352-7359.2004

E. Foy, R. Sumpter-jr, Y. Loo, C. Johnson, C. Wang et al., Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling, Proc. Natl. Acad. Sci.USA, pp.2286-2291, 2005.
DOI : 10.1073/pnas.0408824102

M. Otzuka, N. Kato, M. Moriyama, H. Taniguchi, Y. Wang et al., Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses, Hepatology, vol.171, issue.5, pp.1004-1012, 2005.
DOI : 10.1002/hep.20666

E. Meylan, J. Curran, K. Hofmann, M. Moradpour, R. Bartenschlager et al., Cardif: A Protein Central to Innate Immunity is Inactivated by the HCV NS3 Serine Protease. Hepatology, pp.615-617, 2006.

K. Li, E. Foy, J. Ferreon, M. Nakamura, A. Ferreon et al., Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF, Proc. Natl. Acad. Sci.USA, pp.2292-2297, 2005.
DOI : 10.1038/nature02099

X. Li, L. Sun, R. Seth, G. Pineda, and C. Zj, Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity, Proc. Natl. Acad. Sci.USA, pp.17717-17722, 2005.
DOI : 10.1128/JVI.79.17.10968-10977.2005

G. Mottola, G. Cardinali, A. Ceccacci, C. Trozzi, L. Bartholomew et al., Hepatitis C Virus Nonstructural Proteins Are Localized in a Modified Endoplasmic Reticulum of Cells Expressing Viral Subgenomic Replicons, Virology, vol.293, issue.1, pp.31-43, 2002.
DOI : 10.1006/viro.2001.1229

-. T. Wright, The structural puzzle of how serpin serine proteinase inhibitors work, BioEssays, vol.24, issue.3, pp.453-464, 1996.
DOI : 10.1002/bies.950180607

-. G. Arlaud and S. G. Reboul-a, Interaction of C-inhibitor with the Cr and Cs subcomponents in human C, Biochimica et Biophysica Acta (BBA) - Protein Structure, vol.576, issue.1, pp.151-162, 1979.
DOI : 10.1016/0005-2795(79)90494-X

C. Dumestre-perard, D. Ponard, C. Drouet, V. Leroy, J. Zarski et al., Complement C4 monitoring in the follow-up of chronic hepatitis C treatment, Clinical & Experimental Immunology, vol.166, issue.1, pp.131-137, 2002.
DOI : 10.1046/j.1365-2249.2002.01729.x

E. Kitazawa, T. Igarashi, H. Kawaguchi, Y. Kawashima, R. Hankins et al., Differences in Anti-LKM-1 Autoantibody Immunoreactivity to CYP2D6 Antigenic Sites Between Hepatitis C Virus-negative and -positive Patients, Journal of Autoimmunity, vol.17, issue.3, pp.243-249, 2001.
DOI : 10.1006/jaut.2001.0565

Y. Ma, M. Thomas, M. Okamoto, D. Bogdanos, S. Nagl et al., Key Residues of a Major Cytochrome P4502D6 Epitope Are Located on the Surface of the Molecule, The Journal of Immunology, vol.169, issue.1, pp.277-285, 2002.
DOI : 10.4049/jimmunol.169.1.277