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Synthesis, characterization and biomedical interest of amphiphilic biocompatible and bioeliminable (glyco)copolymers of various architectures

Abstract : This work mainly aims at modifying the surface of polymer nanoparticles (NP) by novel biocompatible amphiphilic copolymers, composed of hydrophilic ethylene oxide (EO) units and hydrophobic ε-caprolactone (CL) units. Copolymers of different architectures have been considered, i.e., diblock copolymers, graft copolymers and star-shaped copolymers.
Poly(ethylene oxide) chains α-terminated by an ε-caprolactone group and ω-end-capped by a methoxy group (γPEO.CL) were synthesized and used, (i) as PEO macromonomers that were copolymerized by ring-opening polymerization (ROP) with ε-caprolactone (ε-CL) to give PCL-g-PEO graft copolymers, and (ii) as precursors for a AB-double headed PEO chain, that were used to initiate selectively the polymerization of two different monomers to form an ABC mikto-arm star copolymer.
The amphiphilic PEO/PCL diblock and graft copolymers were used as stabilizers and surface modifiers of polymer nanoparticles (NP). The effect of the copolymer structural features (architecture, composition and amount) on the formation and structure of the NP was investigated. The complement activation, i.e., the stealthiness of the nanoparticles, as a function of the composition and architecture of the copolymer used as a stabilizer was studied.
Another challenge of this work was to decorate the surface of such NP by mannose moieties, which are suitable targeting probes for dendritic, mannose-receptor expressing cells. Therefore, mannose derivatives were covalently attached as α-end-group to poly(ε-caprolactone) and PEO-b-PCL diblock copolymers. It was found that the NPs' surface properties were strongly related to the glyco(co)polymers used for their preparation.
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Submitted on : Sunday, May 28, 2006 - 7:48:55 PM
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Rieger Jutta. Synthesis, characterization and biomedical interest of amphiphilic biocompatible and bioeliminable (glyco)copolymers of various architectures. Other. Université Joseph-Fourier - Grenoble I, 2006. English. ⟨tel-00076829⟩

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