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Etude des effets des peptides amyloïdes : du fonctionnement de la synapse aux modifications du cytosquelette dans l'apoptose neuronale.

Abstract : Amyloid peptide accumulation is a key factor in Alzheimer's disease pathology. For
this work, we have shown different effects of these peptides.
We have shown the effects of different Aβ peptides on calcium currents of
hippocampal neurons. Thus, Aβ(25-35) increases type L calcium currents whereas Aβ(1-40)
increases non-L type calcium currents.
We next shown that Aβ application decreases evoked excitatory postsynaptic currents
and spontaneous miniature courants. These decreases are due to internalisation of AMPA
receptors and imply inflammatory processes and tranduction pathways activation.
Finally, we shown that during apoptosis induced by amyloid peptide, class III β-
tubulin is excluded from microtubules and forms cytoplasmic aggregates. These effects are
not due to changes in post-translationnal modifications of tubulin.
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https://tel.archives-ouvertes.fr/tel-00069706
Contributor : Francoise Tchang <>
Submitted on : Wednesday, July 12, 2006 - 11:02:14 AM
Last modification on : Thursday, December 10, 2020 - 10:54:59 AM
Long-term archiving on: : Friday, November 25, 2016 - 11:19:26 AM

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Nicolas Arbez. Etude des effets des peptides amyloïdes : du fonctionnement de la synapse aux modifications du cytosquelette dans l'apoptose neuronale.. Neurosciences [q-bio.NC]. Université René Descartes - Paris V, 2005. Français. ⟨tel-00069706v2⟩

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