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Theses

Recherche de lois de mélange sur des propriétés mécaniques de systèmes granulaires compactés

Abstract : The tablet remains the dosage form the most present on the market. These tablets are obtained by the compaction of complex mixtures of an active substance and some excipients.
The aim of this work was to evaluate the behaviour of various binary mixtures of three pharmaceutical excipients.
The first part of this work is about the study of the compressibility and the compactibility of the excipients alone. Tests of characterization of the solid fraction by microtomography X supplemented this study.
The second part deals with the study of the variation of compressibility and mechanical properties when the binary mixture composition changes. Microtomography X were also carried out on one of the mixture.
This work was supplemented by the proposal for a model to describe the evolution of the Young's modulus and the tensile strength according to the mixture composition.
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Contributor : Virginie Busignies <>
Submitted on : Friday, April 21, 2006 - 4:40:16 PM
Last modification on : Wednesday, October 14, 2020 - 3:42:22 AM
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Virginie Busignies. Recherche de lois de mélange sur des propriétés mécaniques de systèmes granulaires compactés. Sciences pharmaceutiques. Université Paris Sud - Paris XI, 2005. Français. ⟨tel-00012167⟩

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