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Mécanisme et conséquences métaboliques de l'internalisation de l'hormone de croissance

Abstract : All known biological activities of GH are initiated by Growth Hormone (GH) interaction with its specific dimerized membrane-bound receptor (GHR) present at the surface of target cells, leading to the activation of intracellular signal transduction. In parallel, the complex GH-GHR2 is internalized in many compartments, including mitochondrion. The aim of this study was to determine caveolae pathway implication in the regulation of GH action at the mitochondrial function level. We showed the importance of the GHR box 1 to stimulate respiratory activity. We also characterized the caveolae pathway in leading GH to enter in the mitochondrial compartment. Its particular localization in the mitochondrial inner membrane allowed GH to directly regulate some respiratory chain complexes. These results suggest a new way of direct action for GH on mitochondria
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Contributor : Frédérique Cohen-Adad <>
Submitted on : Friday, March 24, 2006 - 3:13:56 PM
Last modification on : Friday, October 23, 2020 - 4:38:17 PM
Long-term archiving on: : Saturday, April 3, 2010 - 11:02:27 PM


  • HAL Id : tel-00012032, version 1



Cécile Vivancos. Mécanisme et conséquences métaboliques de l'internalisation de l'hormone de croissance. Physiologie [q-bio.TO]. Université Claude Bernard - Lyon I, 2004. Français. ⟨tel-00012032⟩



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