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ORGANISATION STRUCTURALE ET FONCTION METABOLIQUE DES UNITES ENERGETIQUES INTRACELLULAIRES (ICEUs) DANS LE MUSCLE CARDIAQUE ET SQUELETTIQUE :

Conditions physiologiques et pathophysiologiques

Abstract : The aim of this work was to study the regulation of mitochondrial respiration in situ in cardiac and skeletal muscle cells. Oxygraphy, spectrophotometry and confocal microscopy on saponin-permeabilized muscle cells or fibers were used as well as mathematic modelisation. In muscle cells, mitochondria are ordered very precisely in ‘a crystal like pattern'. This intracellular arrangement could be the basis of a structural and functional organisation within which mitochondria are functionally coupled by cytoskeleton to the other organelles: sarcoplasmic reticulum and myofibrils: ICEUs (intracellular energetic units). In cardiac cells, there are two levels of regulation of mitochondrial respiration by exogenous ADP: permeability of the outer mitochondrial membrane (VDAC) and localized restrictions of ADP diffusion in the neighbourhood of mitochondria. Β-tubulin and STOP protein, a microtubule-associated protein, participate indirectly to these mechanisms of regulation. These experimental data are useful for explaining the metabolic aspects of the Frank-Starling law of the heart. The notion of ICEU can be diagnostically used in clinical study of energetic metabolism of lung recipients transplants before and after a home-interval training program
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https://tel.archives-ouvertes.fr/tel-00011814
Contributor : Karen Guerrero <>
Submitted on : Wednesday, March 8, 2006 - 12:11:16 PM
Last modification on : Friday, November 6, 2020 - 4:07:25 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 4:48:00 PM

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Karen Guerrero. ORGANISATION STRUCTURALE ET FONCTION METABOLIQUE DES UNITES ENERGETIQUES INTRACELLULAIRES (ICEUs) DANS LE MUSCLE CARDIAQUE ET SQUELETTIQUE :

Conditions physiologiques et pathophysiologiques. Physiologie [q-bio.TO]. Ecole pratique des hautes études - EPHE PARIS; Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00011814⟩

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