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Theses

ETUDE DE LA DEACETYLASE HDAC6 : UNE ENZYME MULTIFONCTIONNELLE

Abstract : HDAC6 is a multifunctional enzyme with two tandem catalytic domains and an ubiquitin binding domain. Mainly cytoplasmic, HDAC6 is associated with microtubules, and deacetylates tubulin on lysine 40. Furthermore, cellular management of misfolded proteins and aggresomes is modulated by HDAC6 action. This protein also regulates the acetylation of various proteins, like histones or HSP90, and is involved in several cellular processes. First of all, my work describes additional functions of HDAC6 in stress response. I show that HDAC6 controls HSPs genes activation and the cellular recovery process within the context of cellular stress response. Then the discovery of SE14 domain in the human HDAC6 is an original aspect of this study. This domain is a key element in the human HDAC6 retention in the cytoplasm. Moreover in vitro and in vivo experiences have shown that integrity of both deacetylation domains is required for HDAC6 activity. Finally, this work shows that HDAC6 is involved in osteoclast differentiation. Indeed HDAC6 interacts with mDIA2 and is probably involved in the rearrangement of the cytosqueletton during osteoclast maturation.
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https://tel.archives-ouvertes.fr/tel-00011701
Contributor : Benoit Gilquin <>
Submitted on : Wednesday, March 1, 2006 - 12:32:11 PM
Last modification on : Friday, November 6, 2020 - 3:46:41 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 4:46:26 PM

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  • HAL Id : tel-00011701, version 1

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Benoit Gilquin. ETUDE DE LA DEACETYLASE HDAC6 : UNE ENZYME MULTIFONCTIONNELLE. Biologie cellulaire. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00011701⟩

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