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Vers un modèle dynamique du méristème apical caulinaire d'Arabidopsis thaliana

Abstract : The huge quantity of data generated by the "large scale" biology allows for
a new approach of developmental biology: an approach based on modeling at
a cellular level. Nowadays, genetic patterns and genetics pathways
involved in morphogenesis begin to be analyzable. In that context, it becomes
possible to understand how the plants architecture may be influenced by these
cellular or molecular scale mechanisms.

In a first part of this work, tools dedicated to digitization and analysis of
cellular tissues and their evolution through time were developed. We set up
a software chain for quantitative analysis of morphological characteristics of
plant tissues through time, starting from images created using an acquisition
protocol based on confocal microscopy.

Then, we developed a first growth model of the shoot apical meristem (a
population of stem cells in the plants) to study the initiation of lateral
organs. To account for existing biological knowledge, our model was developed
at organ scale. The genetic state, the physiological state and the growth of
each cell are simulated together with hormones fluxes between cells. This model
allowed for prediction and analysis of accumulation zones of hormones in
digitized meristems. Thanks to these studies, we were able to develop a dynamic
model of the meristem from which phyllotactic patterns emerge from cell growth
and cell-cell interactions.

All the computer tools developed during this PhD have been integrated into
a multi-language software platform. In particular, this platform was used to
test different software development techniques involved in the integration of
compiled and interpreted languages in the context of morphogenesis study.
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Submitted on : Wednesday, February 22, 2006 - 4:02:01 PM
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  • HAL Id : tel-00011669, version 1



Pierre Barbier de Reuille. Vers un modèle dynamique du méristème apical caulinaire d'Arabidopsis thaliana. Autre [cs.OH]. Université Montpellier II - Sciences et Techniques du Languedoc, 2005. Français. ⟨tel-00011669⟩



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