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Le complexe de la NADPH oxydase : études structurales des facteurs cytosoliques.

Abstract : The NADPH oxidase complex of neutrophils catalyses the formation of superoxyde
ions involved in the elimination of pathogenes. It contains two membrane proteins (gp91phox,
p22phox), three cytosolic factors (p47phox, p67phox, p40phox), and a small G protein, Rac. In order
to understand interactions and structural modifications, structural studies of full-length
cytosolic factors alone and complexed have been undertaken. Two approaches have been
selected : electron microscopy and small angle X-ray scattering. The shape of p47phox and
p67phox have been calculated using X-ray scattering.
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https://tel.archives-ouvertes.fr/tel-00011537
Contributor : Virginie Dubosclard <>
Submitted on : Saturday, February 4, 2006 - 12:03:36 PM
Last modification on : Wednesday, November 4, 2020 - 2:23:57 PM
Long-term archiving on: : Saturday, April 3, 2010 - 7:38:15 PM

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Virginie Dubosclard. Le complexe de la NADPH oxydase : études structurales des facteurs cytosoliques.. Biophysique [physics.bio-ph]. Université Joseph-Fourier - Grenoble I, 2004. Français. ⟨tel-00011537⟩

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