S. Aendekerk, S. P. Diggle, Z. Song, N. Hoiby, P. Cornelis et al., The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication, Microbiology, vol.151, issue.4, pp.1113-1125, 2005.
DOI : 10.1099/mic.0.27631-0

K. S. Ahn, U. Ha, J. Jia, D. Wu, J. et al., The truA gene of Pseudomonas aeruginosa is required for the expression of type III secretory genes Microbiology, pp.539-547, 2004.

S. Aizawa, Bacterial flagella and type III secretion systems, FEMS Microbiology Letters, vol.202, issue.2, pp.157-164, 2001.
DOI : 10.1111/j.1574-6968.2001.tb10797.x

A. M. Albus, E. C. Pesci, L. J. Runyen-janecky, S. E. West, and B. H. Iglewski, Vfr controls quorum sensing in Pseudomonas aeruginosa., Journal of Bacteriology, vol.179, issue.12, pp.3928-3935, 1997.
DOI : 10.1128/jb.179.12.3928-3935.1997

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC179201

D. M. Anderson, K. S. Ramamurthi, C. Tam, and O. Schneewind, YopD and LcrH Regulate Expression of Yersinia enterocolitica YopQ by a Posttranscriptional Mechanism and Bind to yopQ RNA, Journal of Bacteriology, vol.184, issue.5, pp.1287-1295, 2002.
DOI : 10.1128/JB.184.5.1287-1295.2002

C. Arevalo-ferro, M. Hentzer, G. Reil, A. Gorg, S. Kjelleberg et al., by proteomics, Environmental Microbiology, vol.3, issue.12, pp.1350-1369, 2003.
DOI : 10.1046/j.1462-2920.2003.00532.x

V. Bajaj, C. Hwang, L. , and C. A. , hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes, Molecular Microbiology, vol.18, issue.4, pp.715-727, 1995.
DOI : 10.1111/j.1365-2958.1995.mmi_18040715.x

V. Bajaj, R. L. Lucas, C. Hwang, L. , and C. A. , Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression, Molecular Microbiology, vol.22, issue.4, pp.703-714, 1996.
DOI : 10.1046/j.1365-2958.1996.d01-1718.x

J. T. Barbieri and J. Sun, Pseudomonas aeruginosa ExoS and ExoT Rev, Physiol Biochem.Pharmacol, vol.152, pp.79-92, 2004.

A. P. Barker, A. I. Vasil, A. Filloux, G. Ball, P. J. Wilderman et al., A novel extracellular phospholipase C of Pseudomonas aeruginosa is required for phospholipid chemotaxis, Molecular Microbiology, vol.66, issue.4, pp.1089-1098, 2004.
DOI : 10.1111/j.1365-2958.2004.04189.x

M. A. Baxter, T. F. Fahlen, R. L. Wilson, and B. D. Jones, HilE Interacts with HilD and Negatively Regulates hilA Transcription and Expression of the Salmonella enterica Serovar Typhimurium Invasive Phenotype, Infection and Immunity, vol.71, issue.3, pp.1295-1305, 2003.
DOI : 10.1128/IAI.71.3.1295-1305.2003

G. Bernot, J. P. Comet, A. Richard, and J. And-guespin, Application of formal methods to biological regulatory networks: extending Thomas??? asynchronous logical approach with temporal logic, Journal of Theoretical Biology, vol.229, issue.3, pp.339-347, 2004.
DOI : 10.1016/j.jtbi.2004.04.003

I. Bertani, M. Sevo, M. Kojic, and V. Venturi, Role of GacA, LasI, RhlI, Ppk, PsrA, Vfr and ClpXP in the regulation of the stationary-phase sigma factor rpoS/RpoS in Pseudomonas, Archives of Microbiology, vol.180, issue.4, pp.264-271, 2003.
DOI : 10.1007/s00203-003-0586-8

S. Bleves, C. Soscia, P. Nogueira-orlandi, A. Lazdunski, and A. Filloux, Quorum Sensing Negatively Controls Type III Secretion Regulon Expression in Pseudomonas aeruginosa PAO1, Journal of Bacteriology, vol.187, issue.11, pp.3898-3902, 2005.
DOI : 10.1128/JB.187.11.3898-3902.2005

B. R. Boles, M. Thoendel, and P. K. Singh, from biofilms, Molecular Microbiology, vol.60, issue.5, pp.1210-1223, 2005.
DOI : 10.1111/j.1365-2958.2005.04743.x

M. M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3

V. H. Bustamante, F. J. Santana, E. Calva, and J. L. Puente, Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H-NS-dependent repression, Molecular Microbiology, vol.12, issue.3, pp.664-678, 2001.
DOI : 10.1046/j.1365-2958.1996.531415.x

E. D. Cambronne and O. Schneewind, Yersinia enterocolitica Type III Secretion: yscM1 and yscM2 Regulate yop Gene Expression by a Posttranscriptional Mechanism That Targets the 5' Untranslated Region of yop mRNA, Journal of Bacteriology, vol.184, issue.21, pp.5880-5893, 2002.
DOI : 10.1128/JB.184.21.5880-5893.2002

E. D. Cambronne, J. A. Sorg, and O. Schneewind, Binding of SycH Chaperone to YscM1 and YscM2 Activates Effector yop Expression in Yersinia enterocolitica, Journal of Bacteriology, vol.186, issue.3, pp.829-841, 2004.
DOI : 10.1128/JB.186.3.829-841.2004

H. Cao, G. Krishnan, B. Goumnerov, J. Tsongalis, R. Tompkins et al., A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism, Proceedings of the National Academy of Sciences, vol.180, issue.9, pp.14613-14618, 2001.
DOI : 10.1016/0092-8674(95)90163-9

J. Casadesus and R. Ari, Memory in bacteria and phage, BioEssays, vol.73, issue.6, pp.512-518, 2002.
DOI : 10.1002/bies.10102

S. A. Chugani, M. Whiteley, K. M. Lee, D. D-'argenio, C. Manoil et al., QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences, vol.22, issue.22, pp.2752-2757, 2001.
DOI : 10.1093/nar/22.22.4673

J. Coburn and D. M. Gill, ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S, Infect.Immun, vol.59, pp.4259-4262, 1991.

M. Cohn and K. Horibata, Analysis of the differentiation and of the heterogeneity within a population of Escherichia coli undergoing induced ?-galactosidase synthesis, J.Bacteriol, vol.78, pp.613-623, 1959.

M. Cohn and K. Horibata, Inhibition by glucose of the induced synthesis of the ?galactoside-enzyme system of Eschercichia coli, Analysis of maintenance J.Bacteriol, vol.78, pp.601-611, 1959.

M. Cohn and K. Horibata, Physiology of the inhibition by glucose of the induced synthesis of the ?-galactoside-enzyme system of Eschercichia coli, J.Bacteriol, vol.78, pp.624-635, 1959.

J. C. Comolli, A. R. Hauser, L. Waite, C. B. Whitchurch, J. S. Mattick et al., Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia, Infect.Immun, vol.67, pp.3625-3630, 1999.

R. Corech, A. Rao, A. Laxova, J. Moss, M. J. Rock et al., Early Immune Response to the Components of the Type III System of Pseudomonas aeruginosa in Children with Cystic Fibrosis, Journal of Clinical Microbiology, vol.43, issue.8, pp.3956-3962, 2005.
DOI : 10.1128/JCM.43.8.3956-3962.2005

G. R. Cornelis and H. Wolf-watz, The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells, Molecular Microbiology, vol.23, issue.5, pp.861-867, 1997.
DOI : 10.1046/j.1365-2958.1997.2731623.x

B. A. Cowell, D. J. Evans, and S. M. Fleiszig, invasion, FEMS Microbiology Letters, vol.250, issue.1, pp.71-76, 2005.
DOI : 10.1016/j.femsle.2005.06.044

D. 'argenio, D. A. Calfee, M. W. Rainey, P. B. Pesci, and E. C. , Autolysis and Autoaggregation in Pseudomonas aeruginosa Colony Morphology Mutants, Journal of Bacteriology, vol.184, issue.23, pp.6481-6489, 2002.
DOI : 10.1128/JB.184.23.6481-6489.2002

D. 'argenio, D. A. Gallagher, L. A. Berg, C. A. Manoil, and C. , Drosophila as a Model Host for Pseudomonas aeruginosa Infection, Journal of Bacteriology, vol.183, issue.4, pp.1466-1471, 2001.
DOI : 10.1128/JB.183.4.1466-1471.2001

D. Dacheux, I. Attree, C. Schneider, and B. Toussaint, Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system, Infect.Immun, vol.67, pp.6164-6167, 1999.

D. Dacheux, I. Attree, and B. Toussaint, Expression of ExsA in trans Confers Type III Secretion System-Dependent Cytotoxicity on Noncytotoxic Pseudomonas aeruginosa Cystic Fibrosis Isolates, Infection and Immunity, vol.69, issue.1, pp.538-542, 2001.
DOI : 10.1128/IAI.69.1.538-542.2001

D. Dacheux, O. Epaulard, A. De-groot, B. Guery, R. Leberre et al., Activation of the Pseudomonas aeruginosa Type III Secretion System Requires an Intact Pyruvate Dehydrogenase aceAB Operon, Infection and Immunity, vol.70, issue.7, pp.3973-3977, 2002.
DOI : 10.1128/IAI.70.7.3973-3977.2002

K. H. Darwin and V. L. Miller, InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium, J.Bacteriol, vol.181, pp.4949-4954, 1999.

N. Dasgupta, G. L. Lykken, M. C. Wolfgang, Y. , and T. L. , A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system, Molecular Microbiology, vol.95, issue.1, pp.297-308, 2004.
DOI : 10.1111/j.1365-2958.2004.04128.x

M. E. Davey, N. C. Caiazza, O. Toole, and G. A. , Rhamnolipid Surfactant Production Affects Biofilm Architecture in Pseudomonas aeruginosa PAO1, Journal of Bacteriology, vol.185, issue.3, pp.1027-1036, 2003.
DOI : 10.1128/JB.185.3.1027-1036.2003

H. Feltman, G. Schulert, S. Khan, M. Jain, L. Peterson et al., Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa, Microbiology, vol.147, issue.10, pp.2659-2669, 2001.
DOI : 10.1099/00221287-147-10-2659

A. Filloux and I. Vallet, Biofilm : mise en place et organisation d???une communaut?? bact??rienne, m??decine/sciences, vol.19, issue.1, pp.77-83, 2003.
DOI : 10.1051/medsci/200319177

K. P. Fong, W. O. Chung, R. J. Lamont, and D. R. Demuth, Intra- and Interspecies Regulation of Gene Expression by Actinobacillus actinomycetemcomitans LuxS, Infection and Immunity, vol.69, issue.12, pp.7625-7634, 2001.
DOI : 10.1128/IAI.69.12.7625-7634.2001

C. Fuqua and E. P. Greenberg, Self perception in bacteria: quorum sensing with acylated homoserine lactones, Current Opinion in Microbiology, vol.1, issue.2, pp.183-189, 1998.
DOI : 10.1016/S1369-5274(98)80009-X

J. E. Galán, Interactions with Host Cells: Type III Secretion at Work, Annual Review of Cell and Developmental Biology, vol.17, issue.1, pp.53-86, 2001.
DOI : 10.1146/annurev.cellbio.17.1.53

L. A. Gallagher, S. L. Mcknight, M. S. Kuznetsova, E. C. Pesci, and C. Manoil, Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa, Journal of Bacteriology, vol.184, issue.23, pp.6472-6480, 2002.
DOI : 10.1128/JB.184.23.6472-6480.2002

M. J. Gambello and B. H. Iglewski, Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression., Journal of Bacteriology, vol.173, issue.9, pp.3000-3009, 1991.
DOI : 10.1128/jb.173.9.3000-3009.1991

A. K. Ganesan, T. S. Vincent, J. C. Olson, and J. T. Barbieri, Pseudomonas aeruginosa Exoenzyme S Disrupts Ras-mediated Signal Transduction by Inhibiting Guanine Nucleotide Exchange Factor-catalyzed Nucleotide Exchange, Journal of Biological Chemistry, vol.274, issue.31, pp.21823-21829, 1999.
DOI : 10.1074/jbc.274.31.21823

V. E. Garcia, F. C. Soncini, and E. A. Groisman, Mg2+ as an extracellular signal: environmental regulation of, Salmonella virulence Cell, vol.84, pp.165-174, 1996.

J. Garmendia, C. R. Beuzon, J. Ruiz-albert, and D. W. Holden, The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system, Microbiology, vol.149, issue.9, pp.2385-2396, 2003.
DOI : 10.1099/mic.0.26397-0

L. Gilson, A. Kuo, and P. V. Dunlap, AinS and a new family of autoinducer synthesis proteins., Journal of Bacteriology, vol.177, issue.23, pp.6946-6951, 1995.
DOI : 10.1128/jb.177.23.6946-6951.1995

U. M. Goehring, G. Schmidt, K. J. Pederson, K. Aktories, and J. T. Barbieri, The N-terminal Domain of Pseudomonas aeruginosaExoenzyme S Is a GTPase-activating Protein for Rho GTPases, Journal of Biological Chemistry, vol.274, issue.51, pp.36369-36372, 1999.
DOI : 10.1074/jbc.274.51.36369

J. B. Goldberg and G. B. Pier, Pseudomonas aeruginosa lipopolysaccharides and pathogenesis Trends Microbiol, pp.490-494, 1996.

M. D. Goldberg, M. Johnson, J. C. Hinton, W. , and P. H. , Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli, Molecular Microbiology, vol.33, issue.3, pp.549-559, 2001.
DOI : 10.1046/j.1365-2958.2001.02526.x

A. L. Goodman, B. Kulasekara, A. Rietsch, D. Boyd, R. S. Smith et al., A Signaling Network Reciprocally Regulates Genes Associated with Acute Infection and Chronic Persistence in Pseudomonas aeruginosa, Developmental Cell, vol.7, issue.5, pp.745-754, 2004.
DOI : 10.1016/j.devcel.2004.08.020

J. Goranson, A. K. Hovey, and D. W. Frank, Functional analysis of exsC and exsB in regulation of exoenzyme S production by Pseudomonas aeruginosa., Journal of Bacteriology, vol.179, issue.5, pp.1646-1654, 1997.
DOI : 10.1128/jb.179.5.1646-1654.1997

J. R. Govan and G. S. Harris, Pseudomonas aeruginosa and cystic fibrosis: unusual bacterial adaptation and pathogenesis, Microbiol.Sci, vol.3, pp.302-308, 1986.

J. E. Guespin-michel and M. Kaufman, Positive feedback circuits and adaptive regulations in bacteria, Acta Biotheoretica, vol.49, issue.4, pp.207-218, 2001.
DOI : 10.1023/A:1014294120243

J. E. Guespin-michel, B. Polack, and A. Mérieau, Bacterial adaptation and epigenesis Recent Res, Devel.Microbiology, vol.7, pp.289-305, 2003.

J. F. Guespin-michel, G. Bernot, J. P. Comet, A. Merieau, A. Richard et al., Epigenesis and dynamic similarity in two regulatory networks in pseudomonas aeruginosa Acta Biotheor, pp.379-390, 2004.

U. Ha and S. Jin, Growth Phase-Dependent Invasion of Pseudomonas aeruginosa and Its Survival within HeLa Cells, Infection and Immunity, vol.69, issue.7, pp.4398-4406, 2001.
DOI : 10.1128/IAI.69.7.4398-4406.2001

U. H. Ha, J. Kim, H. Badrane, J. Jia, H. V. Baker et al., An in vivo inducible gene of Pseudomonas aeruginosa encodes an anti-ExsA to suppress the type III secretion system, Molecular Microbiology, vol.95, issue.2, pp.307-320, 2004.
DOI : 10.1111/j.1365-2958.2004.04282.x

H. P. Hahn, The type-4 pilus is the major virulence-associated adhesin of Pseudomonas aeruginosa ??? a review, Gene, vol.192, issue.1, pp.99-108, 1997.
DOI : 10.1016/S0378-1119(97)00116-9

K. M. Harrington, I. A. Nazarenko, D. B. Dix, R. C. Thompson, and O. C. Uhlenbeck, In vitro analysis of translational rate and accuracy with an unmodified tRNA, Biochemistry, vol.32, issue.30, pp.7617-7622, 1993.
DOI : 10.1021/bi00081a003

A. R. Hauser, S. Fleiszig, P. J. Kang, K. Mostov, and J. N. Engel, Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells, Infect.Immun, vol.66, pp.1413-1420, 1998.

A. R. Hauser, E. Cobb, M. Bodí, D. Mariscal, J. Vallés et al., Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa, Critical Care Medicine, vol.30, issue.3, pp.521-528, 2002.
DOI : 10.1097/00003246-200203000-00005

L. W. Heck, P. G. Alarcon, R. M. Kulhavy, K. Morihara, M. W. Russell et al., Degradation of IgA proteins by Pseudomonas aeruginosa elastase, J.Immunol, vol.144, pp.2253-2257, 1990.

J. M. Henke and B. L. Bassler, Bacterial social engagements, Trends in Cell Biology, vol.14, issue.11, pp.648-656, 2004.
DOI : 10.1016/j.tcb.2004.09.012

M. L. Henriksson, C. Sundin, A. L. Jansson, Å. Forsberg, R. H. Palmer et al., Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo, Biochemical Journal, vol.367, issue.3, pp.617-628, 2002.
DOI : 10.1042/bj20020714

M. Hentzer, H. Wu, J. B. Andersen, K. Riedel, T. B. Rasmussen et al., Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors EMBO J, pp.3803-3815, 2003.

J. Herz, R. C. Kowal, J. L. Goldstein, and M. S. Brown, Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans- Golgi compartment, EMBO J, vol.9, pp.1769-1776, 1990.

M. Hogardt, M. Roeder, A. M. Schreff, L. Eberl, and J. Heesemann, Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS Microbiology, pp.843-851, 2004.

Y. Q. Hong and B. Ghebrehiwet, Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3, Clinical Immunology and Immunopathology, vol.62, issue.2, pp.133-138, 1992.
DOI : 10.1016/0090-1229(92)90065-V

M. W. Hornef, A. Roggenkamp, A. M. Geiger, M. Hogardt, C. A. Jacobi et al., Triggering the ExoS regulon of Pseudomonas aeruginosa: A GFP-reporter analysis of exoenzyme (Exo) S, ExoT and ExoU synthesis, Microbial Pathogenesis, vol.29, issue.6, pp.329-343, 2000.
DOI : 10.1006/mpat.2000.0398

A. K. Hovey and D. W. Frank, Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon., Journal of Bacteriology, vol.177, issue.15, pp.4427-4436, 1995.
DOI : 10.1128/jb.177.15.4427-4436.1995

C. J. Hueck, Type III protein secretion systems in bacterial pathogens of animals and plants Microbiol, Mol.Biol.Rev, vol.62, pp.379-433, 1998.

Y. Imamura, K. Yanagihara, K. Tomono, H. Ohno, Y. Higashiyama et al., Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection, Journal of Medical Microbiology, vol.54, issue.6, pp.515-518, 2005.
DOI : 10.1099/jmm.0.46004-0

K. S. Ishimoto and S. Lory, Formation of pilin in Pseudomonas aeruginosa requires the alternative sigma factor (RpoN) of RNA polymerase., Proceedings of the National Academy of Sciences, vol.86, issue.6, pp.1954-1957, 1989.
DOI : 10.1073/pnas.86.6.1954

S. Iyoda and H. Watanabe, Positive effects of multiple pch genes on expression of the locus of enterocyte effacement genes and adherence of enterohaemorrhagic Escherichia coli O157 : H7 to HEp-2 cells, Microbiology, vol.150, issue.7, pp.2357-2571, 2004.
DOI : 10.1099/mic.0.27100-0

S. Iyoda and H. Watanabe, ClpXP Protease Controls Expression of the Type III Protein Secretion System through Regulation of RpoS and GrlR Levels in Enterohemorrhagic Escherichia coli, Journal of Bacteriology, vol.187, issue.12, pp.4086-4094, 2005.
DOI : 10.1128/JB.187.12.4086-4094.2005

M. W. Jackson, E. Silva-herzog, and G. V. Plano, The ATP-dependent ClpXP and Lon proteases regulate expression of the Yersinia pestis type III secretion system via regulated proteolysis of YmoA, a small histone-like protein, Molecular Microbiology, vol.15, issue.5, pp.1364-1378, 2004.
DOI : 10.1111/j.1365-2958.2004.04353.x

M. Jain, C. Arvanitis, K. Chu, W. Dewey, E. Leonhardt et al., Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC, Science, vol.297, issue.5578, pp.102-104, 2002.
DOI : 10.1126/science.1071489

M. Jain, D. Ramirez, R. Seshadri, J. F. Cullina, C. A. Powers et al., Type III Secretion Phenotypes of Pseudomonas aeruginosa Strains Change during Infection of Individuals with Cystic Fibrosis, Journal of Clinical Microbiology, vol.42, issue.11, pp.5229-5237, 2004.
DOI : 10.1128/JCM.42.11.5229-5237.2004

K. Kaniga, J. C. Bossio, and J. E. Galan, The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins, Molecular Microbiology, vol.60, issue.4, pp.555-568, 1994.
DOI : 10.1073/pnas.82.4.1074

S. A. Kauffman, Metabolic stability and epigenesis in randomly constructed genetic nets, Journal of Theoretical Biology, vol.22, issue.3, pp.437-467, 1969.
DOI : 10.1016/0022-5193(69)90015-0

B. Kenny, A. Abe, M. Stein, and B. B. Finlay, Enteropathogenic Escherichia coli protein secretion is induced in response to conditions similar to those in the gastrointestinal tract, Infect.Immun, vol.65, pp.2606-2612, 1997.

K. Kimbara and A. M. Chakrabarty, Control of alginate synthesis in Pseudomonas aeruginosa: Regulation of the algR1 gene, Biochemical and Biophysical Research Communications, vol.164, issue.2, pp.601-608, 1989.
DOI : 10.1016/0006-291X(89)91502-7

M. Kleerebezem, L. E. Quadri, O. P. Kuipers, and W. M. De-vos, Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria, Molecular Microbiology, vol.24, issue.5, pp.895-904, 1997.
DOI : 10.1046/j.1365-2958.1997.4251782.x

H. Kobayashi, Airway Biofilms, Treatments in Respiratory Medicine, vol.32, issue.4, pp.241-253, 2005.
DOI : 10.2165/00151829-200504040-00003

T. Kohler, L. K. Curty, F. Barja, C. Van-delden, and J. C. Pechere, Swarming of Pseudomonas aeruginosa Is Dependent on Cell-to-Cell Signaling and Requires Flagella and Pili, Journal of Bacteriology, vol.182, issue.21, pp.5990-5996, 2000.
DOI : 10.1128/JB.182.21.5990-5996.2000

T. Kohler, C. Van-delden, L. K. Curty, M. M. Hamzehpour, and J. C. Pechere, Overexpression of the MexEF-OprN Multidrug Efflux System Affects Cell-to-Cell Signaling in Pseudomonas aeruginosa, Journal of Bacteriology, vol.183, issue.18, pp.5213-5222, 2001.
DOI : 10.1128/JB.183.18.5213-5222.2001

M. Kostakioti, C. L. Newman, D. G. Thanassi, and C. Stathopoulos, Mechanisms of Protein Export across the Bacterial Outer Membrane, Journal of Bacteriology, vol.187, issue.13, pp.4306-4314, 2005.
DOI : 10.1128/JB.187.13.4306-4314.2005

R. Krall, G. Schmidt, K. Aktories, and J. T. Barbieri, Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein, Infection and Immunity, vol.68, issue.10, pp.6066-6068, 2000.
DOI : 10.1128/IAI.68.10.6066-6068.2000

S. L. Kuchma, J. P. Connolly, O. Toole, and G. A. , A Three-Component Regulatory System Regulates Biofilm Maturation and Type III Secretion in Pseudomonas aeruginosa, Journal of Bacteriology, vol.187, issue.4, pp.1441-1454, 2005.
DOI : 10.1128/JB.187.4.1441-1454.2005

D. R. Lambert, C. Sluiters, C. , and G. R. , Role of the transcriptional activator, VirF, and temperature in the expression of the pYV plasmid genes of Yersinia enterocolitica, Mol.Microbiol, vol.6, pp.395-409, 1992.

M. A. Laskowski, E. Osborn, and B. I. Kazmierczak, A novel sensor kinase-response regulator hybrid regulates type III secretion and is required for virulence in Pseudomonas aeruginosa, Molecular Microbiology, vol.28, issue.4, pp.1090-1103, 2004.
DOI : 10.1111/j.1365-2958.2004.04331.x

A. Latifi, M. Foglino, K. Tanaka, P. Williams, and A. Lazdunski, A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS, Molecular Microbiology, vol.21, issue.6, pp.1137-1146, 1996.
DOI : 10.1046/j.1365-2958.1996.00063.x

B. E. Laue, Y. Jiang, S. R. Chhabra, S. Jacob, G. S. Stewart et al., The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis- tetradecenoyl)homoserine lactone, via HdtS, pp.2469-2480, 2000.

A. Lazdunski, Les facteurs de virulences de Pseudomonas aeruginosa et leur régulation, Med Mal Infect, pp.109-118, 1998.

L. Berre, R. Faure, K. Fauvel, H. Viget, N. B. Ader et al., Apoptosis inhibition in P. aeruginosa-induced lung injury influences lung fluid balance Intensive Care Med, pp.1204-1211, 2004.

F. Ledgham, I. Ventre, C. Soscia, M. Foglino, J. N. Sturgis et al., Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR, Molecular Microbiology, vol.98, issue.1, pp.199-210, 2003.
DOI : 10.1046/j.1365-2958.2003.03423.x

V. T. Lee, C. Tam, and O. Schneewind, LcrV, a Substrate for Yersinia enterocolitica Type III Secretion, Is Required for Toxin Targeting into the Cytosol of HeLa Cells, Journal of Biological Chemistry, vol.275, issue.47, pp.36869-36875, 2000.
DOI : 10.1074/jbc.M002467200

V. T. Lee, R. S. Smith, B. Tummler, L. , and S. , Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection Infect, Immun, vol.73, pp.1695-1705, 2005.

J. F. Linares, J. A. Lopez, E. Camafeita, J. P. Albar, F. Rojo et al., Overexpression of the Multidrug Efflux Pumps MexCD-OprJ and MexEF-OprN Is Associated with a Reduction of Type III Secretion in Pseudomonas aeruginosa, Journal of Bacteriology, vol.187, issue.4, pp.1384-1391, 2005.
DOI : 10.1128/JB.187.4.1384-1391.2005

R. L. Lucas, C. P. Lostroh, C. C. Dirusso, M. P. Spector, B. L. Wanner et al., Multiple Factors Independently Regulate hilA and Invasion Gene Expression in Salmonella enterica Serovar Typhimurium, Journal of Bacteriology, vol.182, issue.7, pp.1872-1882, 2000.
DOI : 10.1128/JB.182.7.1872-1882.2000

J. B. Lyczak, C. L. Cannon, P. , and G. B. , Lung Infections Associated with Cystic Fibrosis, Clinical Microbiology Reviews, vol.15, issue.2, pp.194-222, 2002.
DOI : 10.1128/CMR.15.2.194-222.2002

J. S. Matson and M. L. Nilles, LcrG-LcrV Interaction Is Required for Control of Yops Secretion in Yersinia pestis, Journal of Bacteriology, vol.183, issue.17, pp.5082-5091, 2001.
DOI : 10.1128/JB.183.17.5082-5091.2001

M. L. Mccaw, G. L. Lykken, P. K. Singh, Y. , and T. L. , ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon, Molecular Microbiology, vol.70, issue.4, pp.1123-1133, 2002.
DOI : 10.1046/j.1365-2958.2002.03228.x

S. L. Mcknight, B. H. Iglewski, and E. C. Pesci, The Pseudomonas Quinolone Signal Regulates rhl Quorum Sensing in Pseudomonas aeruginosa, Journal of Bacteriology, vol.182, issue.10, pp.2702-2708, 2000.
DOI : 10.1128/JB.182.10.2702-2708.2000

R. Mcnab and R. J. Lamont, Microbial dinner-party conversations: the role of LuxS in interspecies communication, Journal of Medical Microbiology, vol.52, issue.7, pp.541-545, 2003.
DOI : 10.1099/jmm.0.05128-0

T. Miki, N. Okada, and H. Danbara, Two Periplasmic Disulfide Oxidoreductases, DsbA and SrgA, Target Outer Membrane Protein SpiA, a Component of the Salmonella Pathogenicity Island 2 Type III Secretion System, Journal of Biological Chemistry, vol.279, issue.33, pp.34631-34642, 2004.
DOI : 10.1074/jbc.M402760200

V. L. Miller, Connections between transcriptional regulation and type III secretion?, Current Opinion in Microbiology, vol.5, issue.2, pp.211-215, 2002.
DOI : 10.1016/S1369-5274(02)00303-X

D. L. Milton, V. J. Chalker, D. Kirke, A. Hardman, M. Camara et al., The LuxM Homologue VanM from Vibrio anguillarum Directs the Synthesis of N-(3-Hydroxyhexanoyl)homoserine Lactone and N-Hexanoylhomoserine Lactone, Journal of Bacteriology, vol.183, issue.12, pp.3537-3547, 2001.
DOI : 10.1128/JB.183.12.3537-3547.2001

D. Morin, B. Grasland, K. Vallee-rehel, C. Dufau, and D. Haras, On-line high-performance liquid chromatography???mass spectrometric detection and quantification of N-acylhomoserine lactones, quorum sensing signal molecules, in the presence of biological matrices, Journal of Chromatography A, vol.1002, issue.1-2, pp.79-92, 2003.
DOI : 10.1016/S0021-9673(03)00730-1

A. Novick and M. Wiener, ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON, Proc.Natl.Acad.Sci.USA, pp.553-556, 1957.
DOI : 10.1073/pnas.43.7.553

O. 'toole, G. A. Kolter, and R. , biofilm development, Molecular Microbiology, vol.18, issue.2, pp.295-304, 1998.
DOI : 10.1046/j.1365-2958.1998.01062.x

U. A. Ochsner and J. Reiser, Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa., Proceedings of the National Academy of Sciences, vol.92, issue.14, pp.6424-6428, 1995.
DOI : 10.1073/pnas.92.14.6424

E. M. Ozbudak, M. Thattai, H. N. Lim, B. I. Shraiman, and A. Van-oudenaarden, Multistability in the lactose utilization network of, Escherichia coli Nature, vol.427, pp.737-740, 2004.

A. L. Page and C. Parsot, Chaperones of the type III secretion pathway: jacks of all trades, Molecular Microbiology, vol.43, issue.1, pp.1-11, 2002.
DOI : 10.1046/j.1365-2958.2002.03138.x

J. P. Pearson, K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard et al., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes., Proceedings of the National Academy of Sciences, vol.91, issue.1, pp.197-201, 1994.
DOI : 10.1073/pnas.91.1.197

J. P. Pearson, C. Van-delden, and B. H. Iglewski, Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals, J.Bacteriol, vol.181, pp.1203-1210, 1999.

K. J. Pederson and J. T. Barbieri, exoenzyme S is cytotoxic to eukaryotic cells, Molecular Microbiology, vol.138, issue.4, pp.751-759, 1998.
DOI : 10.1046/j.1365-2958.1998.01106.x

J. E. Pennington and M. G. Ehrie, Pathogenesis of Pseudomonas aeruginosa Pneumonia during Immunosuppression, Journal of Infectious Diseases, vol.137, issue.6, pp.764-774, 1978.
DOI : 10.1093/infdis/137.6.764

E. C. Pesci, J. B. Milbank, J. P. Pearson, S. Mcknight, A. S. Kende et al., Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences, vol.96, issue.4, pp.11229-11234, 1999.
DOI : 10.1073/pnas.96.4.1639

E. C. Pesci, J. P. Pearson, P. C. Seed, and B. H. Iglewski, Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa., Journal of Bacteriology, vol.179, issue.10, pp.3127-3132, 1997.
DOI : 10.1128/jb.179.10.3127-3132.1997

S. Petersen and G. M. Young, Essential Role for Cyclic AMP and Its Receptor Protein in Yersinia enterocolitica Virulence, Infection and Immunity, vol.70, issue.7, pp.3665-3672, 2002.
DOI : 10.1128/IAI.70.7.3665-3672.2002

G. B. Pier, CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection, Current Opinion in Microbiology, vol.5, issue.1, pp.81-86, 2002.
DOI : 10.1016/S1369-5274(02)00290-4

G. V. Plano, J. B. Day, and F. Ferracci, Type III export: new uses for an old pathway, Molecular Microbiology, vol.165, issue.2, pp.284-293, 2001.
DOI : 10.1073/pnas.96.11.6456

S. Pukatzki, R. H. Kessin, M. , and J. J. , The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum, Proc.Natl.Acad.Sci.USA, pp.3159-3164, 2002.
DOI : 10.1073/pnas.89.18.8803

L. Quenee, D. Lamotte, and B. Polack, Combined sacB-based negative selection and cre-lox antibiotic marker recycling for efficient gene deletion in Pseudomonas aeruginosa, BioTechniques, vol.38, issue.1, pp.63-67, 2005.
DOI : 10.2144/05381ST01

URL : https://hal.archives-ouvertes.fr/hal-00399228

L. G. Rahme, E. J. Stevens, S. F. Wolfort, J. Shao, R. G. Tompkins et al., Common virulence factors for bacterial pathogenicity in plants and animals, Science, vol.268, issue.5219, pp.1899-1902, 1995.
DOI : 10.1126/science.7604262

K. S. Ramamurthi and O. Schneewind, Species, Annual Review of Cell and Developmental Biology, vol.18, issue.1, pp.107-133, 2002.
DOI : 10.1146/annurev.cellbio.18.012502.105912

K. Regnstrom, S. Sauge-merle, K. Chen, and B. K. Burgess, In Azotobacter vinelandii, the E1 subunit of the pyruvate dehydrogenase complex binds fpr promoter region DNA and ferredoxin I, Proceedings of the National Academy of Sciences, vol.16, issue.22, pp.12389-12393, 1999.
DOI : 10.1093/nar/16.22.10881

C. Reimmann, M. Beyeler, A. Latifi, H. Winteler, M. Foglino et al., The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase, Molecular Microbiology, vol.24, issue.2, pp.309-319, 1997.
DOI : 10.1046/j.1365-2958.1997.3291701.x

A. Reisner, N. Hoiby, T. Tolker-nielsen, and S. Molin, Microbial Pathogenesis and Biofilm Development, Contrib.Microbiol, vol.12, pp.114-131, 2005.
DOI : 10.1159/000081692

A. Rietsch, I. Vallet-gely, S. L. Dove, M. , and J. J. , ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences, vol.28, issue.1, pp.8006-8011, 2005.
DOI : 10.1016/0042-6822(66)90317-5

A. Rietsch, M. C. Wolfgang, M. , and J. J. , Effect of Metabolic Imbalance on Expression of Type III Secretion Genes in Pseudomonas aeruginosa, Infection and Immunity, vol.72, issue.3, pp.1383-1390, 2004.
DOI : 10.1128/IAI.72.3.1383-1390.2004

C. Robinson, S. J. Thompson, and C. Woolhead, Multiple pathways used for the targeting of thylakoid proteins in chloroplasts Traffic, pp.245-251, 2001.

A. Rodrigue, Y. Quentin, A. Lazdunski, V. Méjean, and M. Foglino, Cell signalling by oligosaccharides. Two-component systems in Pseudomonas aeruginosa: why so many?, Trends in Microbiology, vol.8, issue.11, pp.498-504, 2000.
DOI : 10.1016/S0966-842X(00)01833-3

A. Roy-burman, R. H. Savel, S. Racine, B. L. Swanson, N. S. Revadigar et al., Infections, The Journal of Infectious Diseases, vol.183, issue.12, pp.1767-1774, 2001.
DOI : 10.1086/320737

J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular cloning: a laboratory manual

H. Sato, D. W. Frank, C. J. Hillard, J. B. Feix, R. R. Pankhaniya et al., The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU, The EMBO Journal, vol.22, issue.12, pp.2959-2969, 2003.
DOI : 10.1093/emboj/cdg290

T. Sawa, T. L. Yahr, M. Ohora, K. Kurachi, M. A. Gropper et al., Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury Nature Med, pp.392-398, 1999.

S. L. Sayner, D. W. Frank, J. King, H. Chen, J. Vandewaa et al., Paradoxical cAMP-Induced Lung Endothelial Hyperpermeability Revealed by Pseudomonas aeruginosa ExoY, Circulation Research, vol.95, issue.2, pp.196-203, 2004.
DOI : 10.1161/01.RES.0000134922.25721.d9

I. C. Scaletsky, M. L. Silva, and L. R. Trabulsi, Distinctive patterns of adherence of enteropathogenic Escherichia coli to HeLa cells, Infect.Immun, vol.45, pp.534-536, 1984.

L. M. Schechter, S. Jain, S. Akbar, L. , and C. A. , The small nucleoid-binding proteins H-NS, HU, and Fis affect hilA expression in Salmonella enterica serovar Typhimurium Infect, Immun, vol.71, pp.5432-5435, 2003.

T. H. Schroeder, M. M. Lee, P. W. Yacono, C. L. Cannon, A. A. Gerceker et al., CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-??B translocation, Proceedings of the National Academy of Sciences, vol.354, issue.9184, pp.6907-6912, 2002.
DOI : 10.1016/S0140-6736(99)02563-5

M. Schuster, A. C. Hawkins, C. S. Harwood, and E. P. Greenberg, The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing, Molecular Microbiology, vol.22, issue.4, pp.973-985, 2004.
DOI : 10.1046/j.1365-2958.2003.03886.x

M. Schuster, C. P. Lostroh, T. Ogi, and E. P. Greenberg, Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis, Journal of Bacteriology, vol.185, issue.7, pp.2066-2079, 2003.
DOI : 10.1128/JB.185.7.2066-2079.2003

P. C. Seed, L. Passador, and B. H. Iglewski, Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy., Journal of Bacteriology, vol.177, issue.3, pp.654-659, 1995.
DOI : 10.1128/jb.177.3.654-659.1995

C. M. Shaver and A. R. Hauser, Relative Contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to Virulence in the Lung, Infection and Immunity, vol.72, issue.12, pp.6969-6977, 2004.
DOI : 10.1128/IAI.72.12.6969-6977.2004

J. E. Shea, M. Hensel, C. Gleeson, and D. W. Holden, Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium., Proceedings of the National Academy of Sciences, vol.93, issue.6, pp.2593-2597, 1996.
DOI : 10.1073/pnas.93.6.2593

M. P. Sircili, M. Walters, L. R. Trabulsi, and V. Sperandio, Modulation of Enteropathogenic Escherichia coli Virulence by Quorum Sensing, Infection and Immunity, vol.72, issue.4, pp.2329-2337, 2004.
DOI : 10.1128/IAI.72.4.2329-2337.2004

R. S. Smith, E. R. Fedyk, T. A. Springer, N. Mukaida, B. H. Iglewski et al., IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoyl Homoserine Lactone Is Transcriptionally Regulated by NF-??B and Activator Protein-2, The Journal of Immunology, vol.167, issue.1, pp.366-374, 2001.
DOI : 10.4049/jimmunol.167.1.366

R. S. Smith and B. H. Iglewski, P. aeruginosa quorum-sensing systems and virulence, Current Opinion in Microbiology, vol.6, issue.1, pp.56-60, 2003.
DOI : 10.1016/S1369-5274(03)00008-0

URL : https://hal.archives-ouvertes.fr/in2p3-00010893

C. Soulé, Graphic Requirements for Multistationarity, Complexus, vol.1, issue.3, pp.123-133, 2003.
DOI : 10.1159/000076100

V. Sperandio, J. L. Mellies, W. Nguyen, S. Shin, and J. B. Kaper, Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli, Proceedings of the National Academy of Sciences, vol.66, issue.4, pp.15196-15201, 1999.
DOI : 10.2105/AJPH.86.8_Pt_1.1142

M. J. Stark, Multicopy expression vectors carrying the lac represser gene for regulated high-level expression of genes in Escherichia coli, Gene, vol.51, issue.2-3, pp.255-267, 1987.
DOI : 10.1016/0378-1119(87)90314-3

R. C. Murphy, W. Chen, K. B. Lim, M. Hackett, A. I. Vasil et al., A novel class of microbial phosphocholine-specific phospholipases C, Mol.Microbiol, vol.46, pp.661-676, 2002.

C. K. Stover, X. Q. Pham, A. L. Erwin, S. D. Mizoguchi, P. Warrener et al., Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen, Nature, vol.406, pp.959-964, 2000.

J. J. Sun and J. T. Barbieri, Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 Regulator of Kinase (Crk) Proteins, Journal of Biological Chemistry, vol.278, issue.35, pp.32794-32800, 2003.
DOI : 10.1074/jbc.M304290200

C. Sundin, B. Hallberg, and A. Forsberg, induces an irreversible effect on the host cell cytoskeleton in vivo, FEMS Microbiology Letters, vol.234, issue.1, pp.87-91, 2004.
DOI : 10.1111/j.1574-6968.2004.tb09517.x

M. G. Surette, M. B. Miller, and B. L. Bassler, Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production, Proceedings of the National Academy of Sciences, vol.177, issue.23, pp.1639-1644, 1999.
DOI : 10.1126/science.277.5331.1453

A. P. Tampakaki, V. E. Fadouloglou, A. D. Gazi, N. J. Panopoulos, and M. Kokkinidis, Conserved features of type III secretion Cell Microbiol, pp.805-816, 2004.

H. B. Tang, E. Dimango, R. Bryan, M. Gambello, B. H. Iglewski et al., Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection, Infect.Immun, vol.64, pp.37-43, 1996.

K. Tateda, Y. Ishii, M. Horikawa, T. Matsumoto, S. Miyairi et al., The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils Infect, Immun, vol.71, pp.5785-5793, 2003.

M. Teplitski, R. I. Goodier, and B. M. Ahmer, Pathways Leading from BarA/SirA to Motility and Virulence Gene Expression in Salmonella, Journal of Bacteriology, vol.185, issue.24, pp.7257-7265, 2003.
DOI : 10.1128/JB.185.24.7257-7265.2003

R. Thomas, Boolean formalization of genetic control circuits, Journal of Theoretical Biology, vol.42, issue.3, pp.563-585, 1973.
DOI : 10.1016/0022-5193(73)90247-6

R. Thomas, On the Relation Between the Logical Structure of Systems and Their Ability to Generate Multiple Steady States or Sustained Oscillations, Springer Series in Synergies, vol.9, pp.180-193, 1980.
DOI : 10.1007/978-3-642-81703-8_24

R. Thomas, D. Thieffry, and M. Kaufman, Dynamical behaviour of biological regulatory networks???I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state, Bulletin of Mathematical Biology, vol.29, issue.2, pp.247-276, 1995.
DOI : 10.1007/BF02460618

R. Thomas and P. Van-ham, Analyse formelle de circuits de r??gulation g??n??tique: le contr??le de l'immunit?? chez les bact??riophages lambdo??des, Biochimie, vol.56, issue.11-12, p.1529, 1974.
DOI : 10.1016/S0300-9084(75)80277-X

B. Toussaint, I. Delic-attree, and P. M. Vignais, Pseudomonas aeruginosa Contains an IHF-like Protein That Binds to the algD Promoter, Biochemical and Biophysical Research Communications, vol.196, issue.1, pp.416-421, 1993.
DOI : 10.1006/bbrc.1993.2265

T. Umanski, I. Rosenshine, and D. Friedberg, Thermoregulated expression of virulence genes in enteropathogenic, Escherichia coli Microbiology, vol.148, pp.2735-2744, 2002.

M. L. Urbanowski, G. L. Lykken, Y. , and T. L. , A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system, Proceedings of the National Academy of Sciences, vol.102, issue.22, pp.9930-9935, 2005.
DOI : 10.1073/pnas.0503005102

J. Urbonavicius, J. M. Durand, and G. R. Bjork, Three Modifications in the D and T Arms of tRNA Influence Translation in Escherichia coli and Expression of Virulence Genes in Shigella flexneri, Journal of Bacteriology, vol.184, issue.19, pp.5348-5357, 2002.
DOI : 10.1128/JB.184.19.5348-5357.2002

I. Vallet, J. W. Olson, S. Lory, A. Lazdunski, and A. Filloux, The chaperone/usher pathways of Pseudomonas aeruginosa: Identification of fimbrial gene clusters (cup) and their involvement in biofilm formation, biofilm formation Proc.Natl.Acad.Sci.USA, pp.6911-6916, 2001.
DOI : 10.1128/JB.182.14.4012-4021.2000

A. J. Vallis, T. L. Yahr, J. T. Barbieri, and D. W. Frank, Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions, Infect.Immun, vol.67, pp.914-920, 1999.

C. Van-delden, R. Comte, and M. Bally, Stringent Response Activates Quorum Sensing and Modulates Cell Density-Dependent Gene Expression in Pseudomonas aeruginosa, Journal of Bacteriology, vol.183, issue.18, pp.5376-5384, 2001.
DOI : 10.1128/JB.183.18.5376-5384.2001

R. E. Vance, A. Rietsch, M. , and J. J. , Role of the Type III Secreted Exoenzymes S, T, and Y in Systemic Spread of Pseudomonas aeruginosa PAO1 In Vivo, Infection and Immunity, vol.73, issue.3, pp.1706-1713, 2005.
DOI : 10.1128/IAI.73.3.1706-1713.2005

N. B. Viget, B. P. Guery, F. Ader, R. Neviere, S. Alfandari et al., Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury Am, J.Physiol Lung Cell Mol.Physiol, vol.279, pp.1199-1209, 2000.

D. S. Wade, M. W. Calfee, E. R. Rocha, E. A. Ling, E. Engstrom et al., Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa, Journal of Bacteriology, vol.187, issue.13, pp.4372-4380, 2005.
DOI : 10.1128/JB.187.13.4372-4380.2005

V. E. Wagner, D. Bushnell, L. Passador, A. I. Brooks, and B. H. Iglewski, Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment, Journal of Bacteriology, vol.185, issue.7, pp.2080-2095, 2003.
DOI : 10.1128/JB.185.7.2080-2095.2003

V. E. Wagner, R. J. Gillis, and B. H. Iglewski, Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa, Vaccine, vol.22, issue.1, pp.15-20, 2004.
DOI : 10.1016/j.vaccine.2004.08.011

T. Walter and A. Aronson, Specific Binding of the E2 Subunit of Pyruvate Dehydrogenase to the Upstream Region of Bacillus thuringiensis Protoxin Genes, Journal of Biological Chemistry, vol.274, issue.12, pp.7901-7906, 1999.
DOI : 10.1074/jbc.274.12.7901

M. J. Wick, D. W. Frank, D. G. Storey, and B. H. Iglewski, Structure, Function, and Regulation of Pseudomonas Aeruginosa Exotoxin A, Annual Review of Microbiology, vol.44, issue.1, pp.335-363, 1990.
DOI : 10.1146/annurev.mi.44.100190.002003

S. C. Williams, E. K. Patterson, N. L. Carty, J. A. Griswold, A. N. Hamood et al., Pseudomonas aeruginosa Autoinducer Enters and Functions in Mammalian Cells, Journal of Bacteriology, vol.186, issue.8, pp.2281-2287, 2004.
DOI : 10.1128/JB.186.8.2281-2287.2004

M. K. Winson, M. Camara, A. Latifi, M. Foglino, S. R. Chhabra et al., Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa., Pseudomonas aeruginosa Proc.Natl.Acad.Sci.USA, pp.9427-9431, 1995.
DOI : 10.1073/pnas.92.20.9427

H. Withers, S. Swift, W. , and P. , Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria, Current Opinion in Microbiology, vol.4, issue.2, pp.186-193, 2001.
DOI : 10.1016/S1369-5274(00)00187-9

M. C. Wolfgang, V. T. Lee, M. E. Gilmore, L. , and S. , Coordinate Regulation of Bacterial Virulence Genes by a Novel Adenylate Cyclase-Dependent Signaling Pathway, Developmental Cell, vol.4, issue.2, pp.253-263, 2003.
DOI : 10.1016/S1534-5807(03)00019-4

D. J. Wozniak and D. E. Ohman, Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT., Journal of Bacteriology, vol.176, issue.19, pp.6007-6014, 1994.
DOI : 10.1128/jb.176.19.6007-6014.1994

W. Wu, H. Badrane, S. Arora, H. V. Baker, J. et al., MucA-Mediated Coordination of Type III Secretion and Alginate Synthesis in Pseudomonas aeruginosa, Journal of Bacteriology, vol.186, issue.22, pp.7575-7585, 2004.
DOI : 10.1128/JB.186.22.7575-7585.2004

T. L. Yahr, A. K. Hovey, S. M. Kulich, and D. W. Frank, Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene., Journal of Bacteriology, vol.177, issue.5, pp.1169-1178, 1995.
DOI : 10.1128/jb.177.5.1169-1178.1995

J. M. Yarwood and P. M. Schlievert, Quorum sensing in Staphylococcus infections, Journal of Clinical Investigation, vol.112, issue.11, pp.1620-1625, 2003.
DOI : 10.1172/JCI200320442

C. Lami and . Umr, Université d'Évry-Val-d'Essonne

F. De-médecine and P. Recherche, France § Corresponding author Email addresses: DF: dfilopon@chu-grenoble.fr AM: annabelle.merieau@univ-rouen.fr GB: gilles GS: Pseudomonas aeruginosa and cystic fibrosis: unusual bacterial adaptation and pathogenesis, Microbiol Sci, vol.3, pp.302-308, 1986.