41 Hz, H2-, H7-Fmoc), H4 = 3.14 Hz, H3-Gal), p.30760361 ,
(s, 12H, 3 x CH 3 CO + NHCOCH3)) ; solide mousseux blanc, pp.47-51, 1018. ,
23) ont été solubilisés dans du méthanol anhydre (2mg/ml) et une solution de MeONa 1% dans le méthanol a été ajoutée goutte à goutte jusqu'à pH 8, pp.pour Aoa-Muc ,
Tr (gradient A): 10,84 min; Maldi : 2163, pp.3-216202 ,
Tr (gradient A): 10,16 min; Maldi : 2325,01, pp.8-00011396, 2006. ,
difficilement manipulable, a été solubilisé dans 1,4 ml d'H 2 O et analysé par HPLC ml ; 0,00077 mmoles) a alors été ajoutée à la solution, Aoa-MucT, issue.192 ,
sous agitation, 320 ?l de TFA ont été ajoutés. La solution a été agitée pendant 10 min dans la glace puis évaporée à sec, Le résidu a alors été repris dans 3,2 ml d'H 2 O. Le pH de la solution a été ajusté à 4,5 avec une solution NaOH 1M ,
MucTn)MucT (43) a été purifié par HPLC sur une colonne C4 et lyophilisé. 1,2 mg (13 %) de produit ont été obtenus sous forme d ,
66 min; ESI-MS: 7900, p.3449 ,
20 éq) pendant une nuit Le peptide-résine a été lavé avec du DCM (3x) et traité avec TFA ml) Le peptide a ensuite été précipité et lavé ,
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