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SUIVI ENDOCRINIEN DES SPORTIFS DE HAUT NIVEAU : AXES HYPOTHALAMO-HYPOPHYSO-SURRENALIEN ET SOMATOTROPE ET REMODELAGE OSSEUX

Abstract : ALTHOUGH REGULAR PHYSICAL ACTIVITY LEADS TO NUMEROUS HEALTH BENEFITS, ELITE SPORTSMAN HAS FREQUENTLY BEHAVIORS WHOSE ARE HEALTH RISK. USE OF HORMONAL DRUGS (CORTICOSTEROIDS, GROWYH HORMONE) AND EATING DISORDERSIS SPECIALLY COULD IMPAIR HYPOTHALMO PITUITARY AXIS, SOMATOTROPE AXIS AND BONE REMODELING.
THE AIM OF THIS WORK WAS TO DRAW UP A STATE OF KNWOLEDGE OF THE PHYSIOPATHOLGY OF THESE AXES WITH PLASMATIC MEASURES SINCE THIS HAD BEEN LITTLE STUDIED IN ELITE SPORTSMEN.
SO, LOWER BASAL PLASMA CORTISOL VALUES WERE HIGHLY PREDICTIVE OF ADRENAL INSUFFICIENCY AND MIRRORED A RECENT CORTICOSTEROID USE. MOREOVER, THIS RECORDING WAS STRENGHTENED BY 90% OF ADRENAL INSUFFICIENCY IN SPORTSME WHO UNDERWENT A PERI OR INTRAARTICULAR CORTICOSTEROID INFILTRATION. CONVERSELY, IT IS DIFFICULT TO KNOW IF HIGH PLASMA CORTISOL VALUES ARE THE CONCERN OF PHYSIOLOGICAL ADAPTATIONS TO INTENSIVE SPORT PRATICE OR OF PATHOLOGICAL CONDITIONS (CALORIC DEFICIENCY OR DOPING).
BASAL SOMATOTROPE AXIS ANALYSIS IN DIFFERENT CATEGORY OF SPORTSMEN REVEALED THAT THE MEANS VALUES WERE CLOSED TO THOSE OF NON SPORTSMEN OF THE SAME AGE; THE STUDY WHICH WAS PERFORMED IN ELITE CYCLISTS WOMEN SHOWED THAT THE BONE MINERAL DENSITY WAS ALMOST THE SAME AS THIS WAS EXPECTED IN GENERAL POPULATION.
SO, TESTING BASL HORMONAL FUNCTION IS RELEVANT IN THE MEDICAL FOLLOW UP OF ELITE SPORTSMEN. EACH ABNORMAL VALUE HAS TO BE REGARDED AS A PATHOLOGICAL VALUE, SPECIALLY INDUCED BY DRUGS AND/OR EATING DISORDERS.
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https://tel.archives-ouvertes.fr/tel-00011389
Contributor : Michel Guinot <>
Submitted on : Monday, January 16, 2006 - 1:10:51 PM
Last modification on : Wednesday, December 9, 2020 - 3:11:28 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 4:38:50 PM

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  • HAL Id : tel-00011389, version 1

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Michel Guinot. SUIVI ENDOCRINIEN DES SPORTIFS DE HAUT NIVEAU : AXES HYPOTHALAMO-HYPOPHYSO-SURRENALIEN ET SOMATOTROPE ET REMODELAGE OSSEUX. Physiologie [q-bio.TO]. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00011389⟩

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