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Assemblages supramoléculaires à base de hyaluronane modifié chimiquement : synthese et caracterisation physico-chimique

Abstract : The work described in this manuscript deals with the synthesis and the physical-chemistry characterization of new supramolecular assemblies based on a natural polysaccharide, hyaluronan (HA).
The assemblies result from the blend of complementary modified polymers and more precisely from specific multivalent interactions between host molecules, $\beta$-cyclodextrins ($\beta$-CD) and guest molecules, hydrophobic adamantanes (AD), each being grafted on HA chains.
Two different systems were prepared to estimate the influence of the junction energy. The resulting mixtures are stabilized either by single inclusion $\beta$-CD/AD complexes or by pairs of inclusion complexes.
Calorimetric titration experiments allowed to analyse the inclusion properties of host and guest molecules and macromolecules. The aqueous behaviour of modified polysaccharides and the viscoelastic properties were studied by flow and dynamic rheology.
These assemblies are sensitive to external parameters such as salt concentration, polymer concentration, temperature and addition of competitive host molecules. They are transient networks and their dynamic is mainly controlled by the number and the exchange rate of effective inclusion complexes as well as by the mobility of HA chains.
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https://tel.archives-ouvertes.fr/tel-00011174
Contributor : Aurelia Charlot <>
Submitted on : Thursday, December 8, 2005 - 5:38:01 PM
Last modification on : Friday, November 6, 2020 - 3:46:12 AM
Long-term archiving on: : Friday, April 2, 2010 - 11:26:03 PM

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  • HAL Id : tel-00011174, version 1

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Aurelia Charlot. Assemblages supramoléculaires à base de hyaluronane modifié chimiquement : synthese et caracterisation physico-chimique. Matériaux. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00011174⟩

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