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Déplacement de particules et d'objets biologiques sur des guides d'ondes

Abstract : Optical manipulation of particles on the surface of an optical waveguide could be potentially interesting for the development of sorting microsystems. However, the use of these devices is today restricted both by limited propulsion performances and by a lack of knowledge of the physical phenomenon, specially for metallic particles. Up to now, these difficulties have not allowed the manipulation of biological cells on theses devices. To improve the waveguide propulsion efficiency, we developed a simulation code which allowed us to calculate the optical forces on a particle located on the surface of a waveguide. These simulations highlight the presence of repulsive gradient forces on metallic particles for some specific configurations. In the mean time, we developed an experimental set up dedicated to the optical manipulation of particles and we found a large influence of light polarisation on metallic micrometric particles velocities. These observations illustrated gradient forces sign inversion with light polarisation and validated the theoretical model. From a practical point of view, this model allowed the design of optical waveguides optimised for the particle propulsion and experimentally, the use of silicon nitride waveguides highly improved the device performances. These results enabled to extend the field of application of this technique to biology and to perform cell propulsion on optical waveguides.
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https://tel.archives-ouvertes.fr/tel-00010904
Contributor : Stéphanie Gaugiran <>
Submitted on : Tuesday, November 8, 2005 - 11:15:07 AM
Last modification on : Friday, November 6, 2020 - 3:56:00 AM
Long-term archiving on: : Friday, September 14, 2012 - 3:30:23 PM

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  • HAL Id : tel-00010904, version 1

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Stéphanie Gaugiran. Déplacement de particules et d'objets biologiques sur des guides d'ondes. Biophysique [physics.bio-ph]. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00010904⟩

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