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Adhésion cellulaire et tubes de membrane : Quelques aspects dynamiques, mécaniques et rhéologiques

Abstract : In the "adhesion" section, we have shown that the dynamics of vesicle
adhesion induced by specific stickers was either governed by the diffusion of ligands
in the membrane or by the reaction time between immobilized receptors and ligands,
depending on the chemical preparation of the decorated substrate. In contrast, the
early stages of living cell adhesion seem to be controlled by the viscous dissipation
inside the cell.
In the "tubes" section, we have studied the formation and the elongation of
membrane tethers. First, by pulling long tubes from firmly adhered vesicles, we
demonstrated that the resulting unusual force-extension trace was the signature of
an elastic stretching of the lipid membrane. Second, by analyzing both experimentally
and theoretically the interaction and coalescence of two tethers, we proposed a novel
method to determine the bending rigidity of phospholipid vesicles. Third, we have
revisited the mechanical and rheological description of tethers extracted from red
blood cells and we evidenced a shear-thinning behavior of the membrane during the
elongation, which indicates the significant influence of the underlying spectrin
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Contributor : Damien Cuvelier <>
Submitted on : Saturday, October 8, 2005 - 12:50:52 AM
Last modification on : Thursday, December 10, 2020 - 10:50:38 AM
Long-term archiving on: : Friday, April 2, 2010 - 10:52:46 PM


  • HAL Id : tel-00010490, version 1


Damien Cuvelier. Adhésion cellulaire et tubes de membrane : Quelques aspects dynamiques, mécaniques et rhéologiques. Biophysique []. Université Pierre et Marie Curie - Paris VI, 2005. Français. ⟨tel-00010490⟩



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