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Approches bioinformatiques et structurales des replicases virales

Abstract : Virology is increasingly benefiting from bio-informatics approaches. My thesis project concerns the study of protein sequences from single stranded, negative and positive RNA viruses. I have set up VaZyMolO, a database that deals with proteins at a functional and structural level. Based on similarity, it is a tool that defines and classifies protein modules. This approach contributed to the identification of a methyltransferase domain on L proteins of Mononegavirales, and to the definition of the N and P modularity in Paramyxoviridae. The mapping of the Severe Acute Respiratory Syndrome virus genome using VaZyMolO contributed to the structural definition of the nsp9 protein of this virus. My thesis also presents an analysis of the Flaviviridae polymerases. It combines structural analyses and methods that infer evolutionary relationships. In this latter study, I propose a structural model for the GBV-C polymerase, and suggest a new mechanism of initiation of RNA synthesis.
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Contributor : Francois-Patrice Ferron <>
Submitted on : Friday, October 7, 2005 - 6:24:55 PM
Last modification on : Thursday, December 17, 2020 - 10:46:01 AM


  • HAL Id : tel-00010419, version 2



Francois Ferron. Approches bioinformatiques et structurales des replicases virales. Autre [q-bio.OT]. Université de la Méditerranée - Aix-Marseille II, 2005. Français. ⟨tel-00010419v2⟩



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