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Analyse protéomique et fonctionnelle des structures de Maurer, un compartiment sécrétoire de Plasmodium falciparum impliqué dans son développement érythrocytaire

Abstract : The erythrocytic development of P. falciparum, the causative agent of malaria, is responsible for all the symptoms. The parasite blood stages posses several organelles; among them, we focused on the Maurer's clefts, a secretory compartment located in the erythrocyte cytoplasm, which has characteristics of a Golgi apparatus, and participates in the transport of parasite proteins to the erythrocyte membrane. We have undertaken a functional and proteomic study of this compartment. We identified, using a global proteomic approach, several Maurer's clefts proteins whose biological function is being further characterised. Moreover, the characterisation of the interaction between PfSBP1, a transmembrane protein of the Maurer's clefts, and LANCL1, an erythrocyte protein, sheds light on the interactions between the Maurer's clefts and the erythrocyte membrane.
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https://tel.archives-ouvertes.fr/tel-00009549
Contributor : Laetitia Vincensini <>
Submitted on : Tuesday, June 21, 2005 - 12:42:38 PM
Last modification on : Friday, May 29, 2020 - 3:59:51 PM
Long-term archiving on: : Friday, September 14, 2012 - 1:25:10 PM

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  • HAL Id : tel-00009549, version 1

Citation

Laetitia Vincensini. Analyse protéomique et fonctionnelle des structures de Maurer, un compartiment sécrétoire de Plasmodium falciparum impliqué dans son développement érythrocytaire. Biologie cellulaire. Université Pierre et Marie Curie - Paris VI, 2005. Français. ⟨tel-00009549⟩

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