LIGNÉES DE CELLULES ENDOTHÉLIALES HUMAINES COMME MODÈLE DE L'ORGANO-SPÉCIFICITÉ : ÉTUDE DU RÔLE DES CHIMIOKINES ET APPLICATIONS À L'INFLAMMATION CUTANÉE

Abstract : The cell circulation, from blood to tissues, is oriented by a set of specific molecules expressed on endothelial cells of blood vessels. These specific molecules depend on the organ and the microenvironment. From organospecific endothelial cell lines, we studied how the chemokines and their receptors can participate to the endothelium organospecificity. We demonstrated that some chemokines have clearly restricted-action towards one endothelial cell line in term of lymphocyte recruitment and formation of vessels in vitro (angiogenesis). We have elaborated an inflammatory model based on the skin endothelial cells which permits the screening of potential anti-inflammatory molecules towards the skin endothelium in collaboration with the BioEurope Society.
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https://tel.archives-ouvertes.fr/tel-00009374
Contributor : Patricia Leloup <>
Submitted on : Monday, August 1, 2005 - 4:59:12 PM
Last modification on : Wednesday, June 27, 2018 - 8:24:02 AM
Long-term archiving on : Monday, September 20, 2010 - 1:03:01 PM

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  • HAL Id : tel-00009374, version 2

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Claire Crola da Silva. LIGNÉES DE CELLULES ENDOTHÉLIALES HUMAINES COMME MODÈLE DE L'ORGANO-SPÉCIFICITÉ : ÉTUDE DU RÔLE DES CHIMIOKINES ET APPLICATIONS À L'INFLAMMATION CUTANÉE. domain_other. Université d'Orléans, 2004. Français. ⟨tel-00009374v2⟩

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