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MEDECINE NUCLEAIRE ET MALADIE CORONARIENNE : EVALUATION DE TRACEURS DE LA PERFUSION MYOCARDIQUE ET DE LA PLAQUE D'ATHEROME VULNERABLE

Abstract : CORONARY ARTERY DISEASE IS ONE OF THE PRIMARY CAUSE OF MORTALITY WORLDWIDE. NUCLEAR MEDICINE IS THE MAJOR IMAGING TECHNIQUE FOR DIAGNOSIS AND FOLLOWING OF THIS DISEASE. PERFUSION : NOWADAYS, MAJOR RADIOACTIVE AGENTS USED IN CLINICAL PRACTICE ARE MYOCARDIAL PERFUSION TRACERS. THE REFERENCE TRACER IS THALLIUM-201. HOWEVER, 201TL PRESENTS SOME DRAWBACKS. 99MTCN-NOET HAS BEEN PROPOSED FOR ITS REPLACEMENT. THIS STUDY SHOWS THAT IN CONTRAST WITH PREVIOUS STUDIES REALIZED IN VITRO ON CARDIOMYOCYTES, VERAPAMIL, AN L-TYPE CALCIUM CHANNEL INHIBITOR, DOES NOT INHIBIT MYOCARDIAL FIXATION OF 99mTcN-NOET IN VIVO IN DOG. THIS DATA IS IN AGREEMENT WITH THE HYPOTHESIS OF A NON SPECIFIC ENDOTHELIAL FIXATION OF THIS TRACER. MOREOVER, THIS STUDY SHOWS THAT AS A PURE TRACER OF MYOCARDIAL PERFUSION, 99mTcN-NOET CAN ALSO BE USED TO ASSESS MYOCARDIAL VIABILITY ON A MODEL OF MYOCARDIAL CHRONIC INFARCTUS IN RAT. ATHEROSCLEROSIS : DISRUPTION OF VULNERABLE ATHEROSCLEROTIC PLAQUES IS THE MAIN EVENT LEADING TO CORONARY ACCIDENTS. THE SECOND PART OF THIS STUDY CONCERNS THE EVALUATION OF NEW POTENTIAL TRACERS OF THE VULNERABLE ATHEROSCLEROTIC PLAQUE IN AN EXPERIMENTAL MODEL OF RABBIT WITH AN INHERITABLE HYPERCHOLESTEROLEMIA. THE FOUR TRACERS EVALUATED (B2702(R), B2702-I, B2702-TC AND TC-RAFT-B2702) ARE SYNTHETIC PEPTIDES COMPRISING THE RESIDUES 75-84 OF HLA-B2702, A MOLECULE KNOWN TO LINK VCAM-1, AN ADHESION MOLECULE EXPRESSED IN VULNERABLE ATHEROSCLEROTIC PLAQUE. THE AUTORADIOGRAPHY STUDIES SHOW THAT ALL TRACERS ACCUMULATE WITHIN ATHEROSCLEROTIC PLAQUE EXPRESSING VCAM- AND THAT. I-B2702 SHOWS THE BEST PLAQUE/CONTROL FIXATION RATIO.
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https://tel.archives-ouvertes.fr/tel-00009143
Contributor : Alexis Broisat <>
Submitted on : Friday, April 29, 2005 - 2:17:53 PM
Last modification on : Friday, November 6, 2020 - 4:08:29 AM
Long-term archiving on: : Friday, April 2, 2010 - 9:32:51 PM

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  • HAL Id : tel-00009143, version 1

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Alexis Broisat. MEDECINE NUCLEAIRE ET MALADIE CORONARIENNE : EVALUATION DE TRACEURS DE LA PERFUSION MYOCARDIQUE ET DE LA PLAQUE D'ATHEROME VULNERABLE. Médicaments. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00009143⟩

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