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Implication des Bone Morphogenetic Proteins dans le contrôle de la position des précurseurs oligodendrocytaires selon l'axe dorso-ventral de la moelle épinière embryonnaire chez le poulet

Abstract : In the spinal cord, oligodendrocytes, the myelinating cells of the central nervous system, arise from the most ventral part of the neuroepithelium, reflecting the influence of Sonic Hedgehog (SHH), a morphogen secreted by the floor plate. Although the dorsal neuroepithelium does normally not generate oligodendrocytes, it can be induced to do so under certain conditions. This led us to test the idea that dorsal cues could locally inhibit oligodendrogenesis. In ovo removal of the dorsal most part of the spinal cord resulted in the specification of oligodendrocytes dorsal to their normal domain of emergence. Bone morphogenetic proteins (BMPs), expressed dorsally, invariably inhibited oligodendrocyte determination and expression of Olig2, a transcription factor required for this process, in vitro and in vivo, despite the presence of SHH. Thus, BMPs are among the dorsal signals that inhibit oligodendrocyte specification and contribute to the ventral restriction of initial steps of oligodendrogenesis by setting the dorsal border of the oligodendrogenic domain.
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https://tel.archives-ouvertes.fr/tel-00008993
Contributor : Soraya Mekki-Dauriac <>
Submitted on : Tuesday, April 12, 2005 - 1:44:15 AM
Last modification on : Wednesday, January 20, 2021 - 3:24:01 PM
Long-term archiving on: : Friday, April 2, 2010 - 9:52:42 PM

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Soraya Mekki-Dauriac. Implication des Bone Morphogenetic Proteins dans le contrôle de la position des précurseurs oligodendrocytaires selon l'axe dorso-ventral de la moelle épinière embryonnaire chez le poulet. Biologie cellulaire. Université Paul Sabatier - Toulouse III, 2004. Français. ⟨tel-00008993⟩

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