ETUDE PAR SIMULATION DE DYNAMIQUE MOLECULAIRE DE LA VARIABILITE CONFORMATIONNELLE DU DIMERE DE LA SEQUENCE SL1 DU GENOME DE VIH-1

Abstract : The genome of HIV-1, the agent responsible for AIDS, is composed of two identical RNA molecules non-covalently linked near their 5' ends. It was shown that the stem loop SL1 localized in this area is able to initiate the dimerization. The dimerization is a key-step of the life cycle of the virus and involves two kinds of complexes: a kissing-complex and an extended duplex looking like a double helix with two internal bulges. Several divergent structures were published for these two complexes and different mechanisms for the transition between these complexes were considered until now. This work permitted to study the stability of the different published structures and particularly to identify the most probable conformation. In parallel, the study of the mechanism of the transition reveals an intermediate structure in the process. The present study gives a set of informations which are expected to be used in the future for the conception of inhibitors of the dimerization process.
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Submitted on : Wednesday, August 10, 2005 - 3:40:51 PM
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  • HAL Id : tel-00008151, version 3

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Samia Aci. ETUDE PAR SIMULATION DE DYNAMIQUE MOLECULAIRE DE LA VARIABILITE CONFORMATIONNELLE DU DIMERE DE LA SEQUENCE SL1 DU GENOME DE VIH-1. domain_other. Université d'Orléans, 2004. Français. ⟨tel-00008151v3⟩

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