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Rôles des synapses électriques dans la synchronisation neuronale : Une étude théorique

Abstract : The two main modes of interaction between neurons are chemical synapses and electrical synapses. Although they are far less numerous than chemical synapses, electrical synapses have been detected in many regions of the brain where they appear to be involved in neuronal synchronisation. Our theoretical study combining analytical and numerical approaches has revealed that the impact of electrical synapses on neuronal synchronization depend on the excitability properties of neurons which are determined by their ionic current. Combined with inhibitory synapses, electrical synapses may exert either an antagonistic or a cooperative effect on synchronization in a linear manner. However, if inhibitory coupling is sufficiently strong, non-linear effects occur such as electrical synapses enhance the precision and robustness of neural synchronization. Taken together, my thesis work highlights that synchronization mediated by electrical synapses is more flexible than previously predicted.
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Contributor : Benjamin Pfeuty <>
Submitted on : Thursday, January 6, 2005 - 5:43:15 PM
Last modification on : Wednesday, December 9, 2020 - 3:04:58 PM
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  • HAL Id : tel-00007936, version 1

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Benjamin Pfeuty. Rôles des synapses électriques dans la synchronisation neuronale : Une étude théorique. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2004. Français. ⟨tel-00007936⟩

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