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Étude du décalage de phase de lecture dans le génome de Saccharomyces cerevisiæ

Abstract : The ribosomal -1 frameshift is an unconventional mechanism of mRNA translation into protein. It controls the production of two different peptides from only one messenger. Although current examples of frameshifting are mainly limited to viral genomes and transposons, some bacterial and eukaryote events are also documented. My thesis work aimed at the search for frameshift-controlled genes in Saccharomyces cerevisiæ, by experimental biology and bioinformatics approaches. Part of this study was collaborative. During this work, the study of -1 frameshifting mechanism was also tackled. Results enabled to highlight the effect of modifications within the tRNA present in the ribosomal E-site during the shift, on the frameshift efficiency.
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Contributor : Michaël Bekaert <>
Submitted on : Wednesday, January 5, 2005 - 5:20:15 PM
Last modification on : Wednesday, December 9, 2020 - 3:06:03 PM
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  • HAL Id : tel-00007928, version 1


Michaël Bekaert. Étude du décalage de phase de lecture dans le génome de Saccharomyces cerevisiæ. Sciences du Vivant [q-bio]. Université Pierre et Marie Curie - Paris VI, 2004. Français. ⟨tel-00007928⟩



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