.. Modélisation-moléculaire, 105 II-6-1 Etablissement des contraintes, 105 II-6-2 Résolution de la structure tridimensionnelle, p.107

L. Séquences, 2. De-type, and D. , NOESY ont été enregistrés en mode STATES. Les spectres NOESY ont été enregistrés à quatre temps de mélange 50

G. Shaka, avec une puissance de 45dB( pour le 15 N) (la puissance maximale délivrée par le spectromètre est de 63dB) La valeur du ?/2 est de 36, avec une puissance de 44dB, pp.8-15, 1985.

A. Abragam, O. Aldovini, A. Young, and R. , Principles of nuclear magnetism Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus, J Virol, vol.64, pp.1920-1926, 1961.

G. Amarasinghe, D. Guzman, R. Turner, R. Chancellor, K. Wu et al., NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the ??-RNA packaging signal. implications for genome recognition, Journal of Molecular Biology, vol.301, issue.2, pp.491-511, 2000.
DOI : 10.1006/jmbi.2000.3979

G. Amarasinghe, D. Guzman, R. Turner, R. Summers, and M. , NMR structure of stem-loop SL2 of the HIV-1 ?? RNA packaging signal reveals a novel A-U-A base-triple platform, Journal of Molecular Biology, vol.299, issue.1, pp.145-56, 2000.
DOI : 10.1006/jmbi.2000.3710

J. Anderson, R. Teufel, P. Yin, and W. Hu, Correlated template-switching events during minus-strand DNA synthesis: a mechanism for high negative interference during retroviral recombination, J Virol, vol.72, pp.1186-94, 1998.

W. Aue, E. Bartholdi, and R. Ernst, Two???dimensional spectroscopy. Application to nuclear magnetic resonance, The Journal of Chemical Physics, vol.64, issue.5, pp.2229-2246, 1976.
DOI : 10.1063/1.432450

G. Awang and D. Sen, Mode of dimerization of HIV-1 genomic RNA, Biochemistry, vol.32, issue.42, pp.11453-11460, 1993.
DOI : 10.1021/bi00093a024

S. Baba, K. Takahashi, Y. Nomura, S. Noguchi, Y. Koyanagi et al., Conformational change of dimerization initiation site of HIV-1 genomic RNA by NCp7 or heat treatment, Nucleic Acids Symposium Series, vol.1, issue.1, pp.155-161, 2001.
DOI : 10.1093/nass/1.1.155

M. Balakrishnan, P. Fay, and R. Bambara, The Kissing Hairpin Sequence Promotes Recombination within the HIV-I 5' Leader Region, Journal of Biological Chemistry, vol.276, issue.39, pp.36482-92, 2001.
DOI : 10.1074/jbc.M102860200

J. Banks and M. Linial, Secondary Structure Analysis of a Minimal Avian Leukosis-Sarcoma Virus Packaging Signal, Journal of Virology, vol.74, issue.1, pp.456-64, 2000.
DOI : 10.1128/JVI.74.1.456-464.2000

F. Baudin, R. Marquet, C. Isel, J. Darlix, B. Ehresmann et al., Functional Sites in the 5??? Region of Human Immunodeficiency Virus Type 1 RNA Form Defined Structural Domains, Journal of Molecular Biology, vol.229, issue.2, pp.382-97, 1993.
DOI : 10.1006/jmbi.1993.1041

W. Bender and N. Davidson, Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules, Cell, vol.7, issue.4, pp.595-607, 1976.
DOI : 10.1016/0092-8674(76)90210-5

J. Berg, Potential metal-binding domains in nucleic acid binding proteins, Science, vol.232, issue.4749, pp.485-492, 1986.
DOI : 10.1126/science.2421409

B. Berkhout and J. Van-wamel, The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure, RNA, vol.6, issue.2, pp.282-95, 2000.
DOI : 10.1017/S1355838200991684

R. Berkowitz, J. Luban, and S. Goff, Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays, J Virol, vol.67, pp.7190-200, 1993.

S. Bernacchi and Y. Mely, Exciton interaction in molecular beacons: a sensitive sensor for short range modifications of the nucleic acid structure, Nucleic Acids Research, vol.29, issue.13, pp.62-64, 2001.
DOI : 10.1093/nar/29.13.e62

B. Bonnet-mathoniere, P. Girard, D. Muriaux, and J. Paoletti, Nucleocapsid Protein 10 Activates Dimerization of the RNA of Moloney Murine Leukaemia Virus in vitro, European Journal of Biochemistry, vol.223, issue.1, pp.129-164, 1996.
DOI : 10.1016/0168-9525(91)90048-U

P. Borer, L. Pappalardo, D. Kerwood, and I. Pelczer, NMR-based structure determination for unlabelled RNA and DNA, Adv Biophys Chem, vol.6, pp.173-216, 1997.

L. Braunschweiler and R. Ernst, Coherence transfert by isotopic mixing: application to proton correlation spectroscopy, J Magn Reson, vol.53, pp.521-528, 1983.

B. Brooks, R. Bruccoleri, B. Olafson, D. States, S. Swaminathan et al., CHARMM: A program for macromolecular energy, minimization, and dynamics calculations, Journal of Computational Chemistry, vol.I, issue.2, pp.187-217, 1983.
DOI : 10.1002/jcc.540040211

A. Brünger, A. Brünger, P. Adams, G. Clore, D. Lano et al., Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination, Acta Crystallographica Section D Biological Crystallography, vol.54, issue.5, pp.905-926, 1992.
DOI : 10.1107/S0907444998003254

M. Bukrinsky, S. Haggerty, M. Dempsey, N. Sharova, A. Adzhubel et al., A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells, Nature, vol.365, issue.6447, pp.666-675, 1993.
DOI : 10.1038/365666a0

M. Bukrinsky, N. Sharova, T. Mcdonald, T. Pushkarskaya, W. Tarpley et al., Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection., Proceedings of the National Academy of Sciences, vol.90, issue.13, pp.6125-6134, 1993.
DOI : 10.1073/pnas.90.13.6125

E. Canaani, K. Helm, and P. Duesberg, Evidence for 30-40S RNA as Precursor of the 60-70S RNA of Rous Sarcoma Virus, Proceedings of the National Academy of Sciences, vol.70, issue.2, pp.401-406, 1973.
DOI : 10.1073/pnas.70.2.401

J. Cate, A. Gooding, E. Podell, K. Zhou, B. Golden et al., Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing, Science, vol.273, issue.5282, pp.1678-85, 1996.
DOI : 10.1126/science.273.5282.1678

K. Chang, I. Tinoco, and J. , Characterization of a "kissing" hairpin complex derived from the human immunodeficiency virus genome., Proceedings of the National Academy of Sciences, vol.91, issue.18, pp.8705-8714, 1994.
DOI : 10.1073/pnas.91.18.8705

K. Chang, I. Tinoco, and J. , The structure of an RNA ???kissing??? hairpin complex of the HIV TAR hairpin loop and its complement, Journal of Molecular Biology, vol.269, issue.1, pp.52-66, 1997.
DOI : 10.1006/jmbi.1997.1021

K. Chang and G. Varani, Nucleic acids structure and recognition, Nat Struct Biol, vol.4, 1997.

C. Cheong, G. Varani, I. Tinoco, and J. , Solution structure of an unusually stable RNA hairpin, 5GGAC(UUCG)GUCC, Nature, vol.346, issue.6285, pp.680-682, 1990.
DOI : 10.1038/346680a0

F. Clavel and J. Orenstein, A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology, J Virol, vol.64, pp.5230-5234, 1990.

J. Clever, C. Sassetti, and T. Parslow, RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1, J Virol, vol.69, pp.2101-2110, 1995.

J. Clever, D. Mirandar, J. Parslow, and T. , RNA Structure and Packaging Signals in the 5' Leader Region of the Human Immunodeficiency Virus Type 1 Genome, Journal of Virology, vol.76, issue.23, pp.12381-12388, 2002.
DOI : 10.1128/JVI.76.23.12381-12387.2002

J. Clever and T. Parslow, Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation, J Virol, vol.71, pp.3407-3421, 1997.

J. Clever, M. Wong, and T. Parslow, Requirements for kissing-loop-mediated dimerization of human immunodeficiency virus RNA, J Virol, vol.70, pp.5902-5910, 1996.

G. Clore, M. Starich, and A. Gronenborn, Measurement of Residual Dipolar Couplings of Macromolecules Aligned in the Nematic Phase of a Colloidal Suspension of Rod-Shaped Viruses, Journal of the American Chemical Society, vol.120, issue.40, pp.10571-10573, 1998.
DOI : 10.1021/ja982592f

D. Collin, C. Van-heijenoort, C. Boiziau, J. Toulme, and E. Guittet, NMR characterization of a kissing complex formed between the TAR RNA element of HIV-1 and a DNA aptamer, Nucleic Acids Research, vol.28, issue.17, pp.3386-91, 2000.
DOI : 10.1093/nar/28.17.3386

R. Colvin, S. White, M. Garcia-blanco, and D. Hoffman, Structural features of an RNA containing the CUGGGA loop of the human immunodeficiency virus type 1 trans-activation response element, Biochemistry, vol.32, issue.4, pp.1105-1117, 1993.
DOI : 10.1021/bi00055a016

F. Cornille, Y. Mely, D. Ficheux, I. Savignol, D. Gerard et al., Solid phase synthesis of the retro viral nucleocapsid protein NCp10 of Moloney Murine Leukaemia virus and related ???zinc-fingers??? in free SH forms, International Journal of Peptide and Protein Research, vol.27, issue.6, pp.551-559, 1990.
DOI : 10.1111/j.1399-3011.1990.tb00995.x

S. Covey, Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus, Nucleic Acids Research, vol.14, issue.2, pp.623-656, 1986.
DOI : 10.1093/nar/14.2.623

J. Cromsigt, J. Schleucher, T. Gustafsson, J. Kihlberg, and S. Wijmenga, Preparation of partially 2H/13C-labelled RNA for NMR studies. Stereo-specific deuteration of the H5'' in nucleotides, Nucleic Acids Research, vol.30, issue.7, pp.1639-1684, 2002.
DOI : 10.1093/nar/30.7.1639

J. Cromsigt, B. Van-buuren, J. Schleucher, and S. Wijmenga, Resonance Assignment and Structure Determination for RNA, Methods Enzymol, vol.338, pp.371-99, 2001.
DOI : 10.1016/S0076-6879(02)38229-6

J. Dannull, A. Surovoy, G. Jung, and K. Moelling, Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues, Embo J, vol.13, pp.1525-1558, 1994.

F. Dardel, R. Marquet, C. Ehresmann, B. Ehresmann, and S. Blanquet, Solution studies of the dimerization initiation site of HIV-1 genomic RNA, Nucleic Acids Research, vol.26, issue.15, pp.3567-71, 1998.
DOI : 10.1093/nar/26.15.3567

J. Darlix, C. Gabus, M. Nugeyre, F. Clavel, and F. Barre-sinoussi, Cis elements and Trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1, Journal of Molecular Biology, vol.216, issue.3, pp.689-99, 1990.
DOI : 10.1016/0022-2836(90)90392-Y

P. Davanloo, A. Rosenberg, J. Dunn, and F. Studier, Cloning and expression of the gene for bacteriophage T7 RNA polymerase., Proceedings of the National Academy of Sciences, vol.81, issue.7, pp.2035-2044, 1984.
DOI : 10.1073/pnas.81.7.2035

D. Davis and A. Bax, Assignment of complex proton NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy, Journal of the American Chemical Society, vol.107, issue.9, pp.2820-2821, 1985.
DOI : 10.1021/ja00295a052

D. Guzman, R. Wu, Z. Stalling, C. Pappalardo, L. Borer et al., Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 -RNA Recognition Element, Science, vol.279, issue.5349, pp.384-392, 1998.
DOI : 10.1126/science.279.5349.384

H. De-rocquigny, D. Ficheux, C. Gabus, B. Allain, M. Fournie-zaluski et al., Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity, Nucleic Acids Research, vol.21, issue.4, pp.823-832, 1993.
DOI : 10.1093/nar/21.4.823

H. De-rocquigny, D. Ficheux, C. Gabus, M. Fournie-zaluski, J. Darlix et al., First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form, Biochemical and Biophysical Research Communications, vol.180, issue.2, pp.1010-1018, 1991.
DOI : 10.1016/S0006-291X(05)81166-0

H. De-rocquigny, C. Gabus, A. Vincent, M. Fournie-zaluski, B. Roques et al., Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers., Proceedings of the National Academy of Sciences, vol.89, issue.14, pp.6472-6478, 1992.
DOI : 10.1073/pnas.89.14.6472

D. Tapia, M. Metzler, V. Mougel, M. Ehresmann, B. Ehresmann et al., Dimerization of MoMuLV genomic RNA: redefinition of the role of the palindromic stem-loop H1 (278-303) and new roles for stem-loops H2, Biochemistry, vol.37, pp.310-352, 1998.

M. Delepierre, B. Roques, D. Langlois, B. Estaintot, and J. Igolen, P Spectra of Drug-Oligonucleotide Complexes, Journal of Biomolecular Structure and Dynamics, vol.108, issue.4, pp.933-940, 1988.
DOI : 10.1016/0079-6565(86)80005-X

H. Deng, R. Liu, W. Ellmeier, S. Choe, D. Unutmaz et al., Identification of a major co-receptor for primary isolates of HIV-1, Nature, vol.381, issue.6584, pp.661-667, 1996.
DOI : 10.1038/381661a0

A. Dingley and S. Grzesiek, Couplings, Journal of the American Chemical Society, vol.120, issue.33, pp.8293-97, 1998.
DOI : 10.1021/ja981513x

T. Dorfman, J. Luban, S. Goff, W. Haseltine, and H. Gottlinger, Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein, J Virol, vol.67, pp.6159-69, 1993.

N. Doria-rose and V. Vogt, In vivo selection of Rous sarcoma virus mutants with randomized sequences in the packaging signal, J Virol, vol.72, pp.8073-82, 1998.

T. Dragic, V. Litwin, G. Allaway, S. Martin, Y. Huang et al., HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5, Nature, vol.381, issue.6584, pp.667-73, 1996.
DOI : 10.1038/381667a0

P. Dupraz, S. Oertle, C. Meric, P. Damay, and P. Spahr, Point mutations in the proximal Cys- His box of Rous sarcoma virus nucleocapsid protein, J Virol, vol.64, pp.4978-87, 1990.

E. Ennifar, P. Walter, B. Ehresmann, C. Ehresmann, and P. Dumas, Crystal structures of coaxially stacked kissing complexes of the HIV-1 RNA dimerization initiation site, Nature Structural Biology, vol.8, issue.12, pp.1064-1072, 2001.
DOI : 10.1038/nsb727

E. Ennifar, M. Yusupov, P. Walter, R. Marquet, B. Ehresmann et al., The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges, Structure, vol.7, issue.11, pp.1439-1488, 1999.
DOI : 10.1016/S0969-2126(00)80033-7

Y. Feng, C. Broder, P. Kennedy, and E. Berger, HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor, Science, vol.272, issue.5263, pp.872-879, 1996.
DOI : 10.1126/science.272.5263.872

Y. Feng, T. Copeland, L. Henderson, R. Gorelick, W. Bosche et al., HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro., Proceedings of the National Academy of Sciences, vol.93, issue.15, pp.7577-81, 1996.
DOI : 10.1073/pnas.93.15.7577

A. Frankel and J. Young, HIV-1: Fifteen Proteins and an RNA, Annual Review of Biochemistry, vol.67, issue.1, pp.1-25, 1998.
DOI : 10.1146/annurev.biochem.67.1.1

W. Fu, R. Gorelick, and A. Rein, Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virions, J Virol, vol.68, pp.5013-5021, 1994.

H. Gelderblom, E. Hausmann, M. Ozel, G. Pauli, and M. Koch, Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins, Virology, vol.156, issue.1, pp.171-177, 1987.
DOI : 10.1016/0042-6822(87)90449-1

C. Giessner-prettre and B. Pullman, Quantum mechanical calculations of NMR chemical shifts in nucleic acids, Quarterly Reviews of Biophysics, vol.2, issue.3-4, pp.113-72, 1987.
DOI : 10.1038/311584a0

F. Girard, F. Girard, F. Barbault, C. Gouyette, T. Huynh-dinh et al., Genomic RNA: NMR Solution Structure of the Extended Duplex, Journal of Biomolecular Structure and Dynamics, vol.217, issue.6, pp.1145-57, 1999.
DOI : 10.1006/jmbi.1997.1096

P. Girard, B. Bonnet-mathoniere, D. Muriaux, and J. Paoletti, A Short Autocomplementary Sequence in the 5' Leader Region Is Responsible for Dimerization of MoMuLV Genomic RNA, Biochemistry, vol.34, issue.30, pp.9785-94, 1995.
DOI : 10.1021/bi00030a016

C. Glemarec, J. Kufel, A. Foldesi, T. Maltseva, A. Sandstrom et al., The NMR structure of 31mer RNA domain of Escherichia coli RNase P RNA using its non-uniformly deuterium labelled counterpart [the 'NMR- window' concept], Nucleic Acids Research, vol.24, issue.11, pp.2022-2057, 1996.
DOI : 10.1093/nar/24.11.2022

R. Gorelick, L. Henderson, J. Hanser, and A. Rein, Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence., Proceedings of the National Academy of Sciences, vol.85, issue.22, pp.8420-8424, 1988.
DOI : 10.1073/pnas.85.22.8420

D. Gorenstein, K. Lai, and D. Shah, Phosphorus-31 and two-dimensional phosphorus-31/proton correlated NMR spectra of duplex d(Ap[17O]Gp[18O]Cp[16O]T) and assignment of phosphorus-31 signals in d(ApGpCpT)2-actinomycin D complex, Biochemistry, vol.23, issue.26, pp.6717-6740, 1984.
DOI : 10.1021/bi00321a067

L. Green and J. Berg, Retroviral nucleocapsid protein-metal ion interactions: folding and sequence variants., Proceedings of the National Academy of Sciences, vol.87, issue.16, pp.6403-6410, 1990.
DOI : 10.1073/pnas.87.16.6403
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC54542

M. Haddrick, A. Lear, A. Cann, and S. Heaphy, Evidence that a Kissing Loop Structure Facilitates Genomic RNA Dimerisation in HIV-1, Journal of Molecular Biology, vol.259, issue.1, pp.58-68, 1996.
DOI : 10.1006/jmbi.1996.0301

G. Harrison, G. Miele, E. Hunter, and A. Lever, Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line, J Virol, vol.72, pp.5886-96, 1998.

T. Hayashi, T. Shioda, Y. Iwakura, and H. Shibuta, RNA packaging signal of human immunodeficiency virus type 1, Virology, vol.188, issue.2, pp.590-599, 1992.
DOI : 10.1016/0042-6822(92)90513-O

W. Hu and H. Temin, Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination., Proceedings of the National Academy of Sciences, vol.87, issue.4, pp.1556-60, 1990.
DOI : 10.1073/pnas.87.4.1556

S. Huang, Y. Wang, and D. Draper, Structure of a Hexanucleotide RNA Hairpin Loop Conserved in Ribosomal RNAs, Journal of Molecular Biology, vol.258, issue.2, pp.308-329, 1996.
DOI : 10.1006/jmbi.1996.0252

R. Ikeda and P. Bailey, Inhibition of T7 RNA polymerase by T7 lysozyme in vitro, J Biol Chem, vol.267, pp.20153-20161, 1992.

J. Jones, R. Allan, and H. Temin, One retroviral RNA is sufficient for synthesis of viral DNA, J Virol, vol.68, pp.207-223, 1994.

F. Jucker, H. Heus, P. Yip, E. Moors, and A. Pardi, A Network of Heterogeneous Hydrogen Bonds in GNRA Tetraloops, Journal of Molecular Biology, vol.264, issue.5, pp.968-80, 1996.
DOI : 10.1006/jmbi.1996.0690

F. Jucker and A. Pardi, Solution Structure of the CUUG Hairpin Loop: A Novel RNA Tetraloop Motif, Biochemistry, vol.34, issue.44, pp.14416-14443, 1995.
DOI : 10.1021/bi00044a019

F. Kieken, E. Arnoult, F. Barbault, F. Paquet, T. Huynh-dinh et al., HIV-1 Lai genomic RNA: combined used of NMR and molecular dynamics simulation for studying the structure and internal dynamics of a mutated SL1 hairpin, European Biophysics Journal, vol.31, issue.7, pp.521-552, 2002.
DOI : 10.1007/s00249-002-0251-1

C. Kim, I. Tinoco, and J. , A retroviral RNA kissing complex containing only two G{middle dot}C base pairs, Proceedings of the National Academy of Sciences, vol.60, issue.1, pp.9396-401, 2000.
DOI : 10.1146/annurev.bi.60.070191.003215

R. Koradi, M. Billeter, and K. Wuthrich, MOLMOL: A program for display and analysis of macromolecular structures, Journal of Molecular Graphics, vol.14, issue.1, pp.51-55, 1996.
DOI : 10.1016/0263-7855(96)00009-4

C. Kuiken, R. Thakallapalli, A. Esklid, and A. De-ronde, Genetic Analysis Reveals Epidemiologic Patterns in the Spread of Human Immunodeficiency Virus, American Journal of Epidemiology, vol.152, issue.9, pp.814-836, 2000.
DOI : 10.1093/aje/152.9.814

H. Kung, J. Bailey, N. Davidson, M. Nicolson, and R. Mcallister, Structure, subunit composition, and molecular weight of RD-114 RNA, J Virol, vol.16, pp.397-411, 1975.

G. Lancelot, J. Guesnet, and F. Vovelle, Solution structure of the parallel-stranded duplex oligonucleotide .alpha.-d(TCTAAAC)-.beta.-(AGATTTG) via complete relaxation matrix analysis of the NOE effects and molecular mechanics calculations, Biochemistry, vol.28, issue.19, pp.7871-7879, 1989.
DOI : 10.1021/bi00445a049

M. Lapadat-tapolsky, D. Rocquigny, H. Van-gent, D. Roques, B. Plasterk et al., Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle, Nucleic Acids Research, vol.21, issue.4, pp.831-840, 1993.
DOI : 10.1093/nar/21.4.831

J. Lapham, J. Rife, J. Moore, and D. Crothers, Measurement of diffusion constants for nucleic acids by NMR, Journal of Biomolecular NMR, vol.10, issue.3, pp.255-262, 1997.
DOI : 10.1023/A:1018310702909

M. Laughrea and L. Jette, A 19-Nucleotide Sequence Upstream of the 5' Major Splice Donor Is Part of the Dimerization Domain of Human Immunodeficiency Virus 1 Genomic RNA, Biochemistry, vol.33, issue.45, pp.13464-74, 1994.
DOI : 10.1021/bi00249a035

M. Laughrea and L. Jette, Kissing-loop model of HIV-1 genome dimerization, p.1, 1996.

R. Lavery and H. Sklenar, The Definition of Generalized Helicoidal Parameters and of Axis Curvature for Irregular Nucleic Acids, Journal of Biomolecular Structure and Dynamics, vol.328, issue.1, pp.63-91, 1988.
DOI : 10.1016/0022-2836(78)90209-7
URL : https://hal.archives-ouvertes.fr/hal-00313457

R. Lavery and H. Sklenar, Defining the Structure of Irregular Nucleic Acids: Conventions and Principles, Journal of Biomolecular Structure and Dynamics, vol.138, issue.4, pp.655-67, 1989.
DOI : 10.1016/0079-6107(70)90027-1
URL : https://hal.archives-ouvertes.fr/hal-00313452

R. Lavery, K. Zakrzewska, and H. Sklenar, JUMNA (junction minimisation of nucleic acids), Computer Physics Communications, vol.91, issue.1-3, pp.255-62, 1995.
DOI : 10.1016/0010-4655(95)00046-I

D. Lawrence, C. Stover, J. Noznitsky, Z. Wu, and M. Summers, Structure of the Intact Stem and Bulge of HIV-1 ??-RNA Stem-Loop SL1, Journal of Molecular Biology, vol.326, issue.2, pp.529-571, 2003.
DOI : 10.1016/S0022-2836(02)01305-0

A. Lee and D. Crothers, The solution structure of an RNA loop???loop complex: the ColE1 inverted loop sequence, Structure, vol.6, issue.8, pp.993-1005, 1998.
DOI : 10.1016/S0969-2126(98)00101-4

T. Leeper, M. Martin, H. Kim, S. Cox, V. Semenchenko et al., Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action, Nature Structural Biology, vol.9, pp.397-403, 2002.
DOI : 10.1038/nsb775

P. Legault and A. Pardi, 31P Chemical Shift as a Probe of Structural Motifs in RNA, Journal of Magnetic Resonance, Series B, vol.103, issue.1, pp.82-88, 1994.
DOI : 10.1006/jmrb.1994.1012

N. Leulliot, V. Baumruk, M. Abdelkafi, P. Turpin, A. Namane et al., Unusual nucleotide conformations in GNRA and UNCG type tetraloop hairpins: evidence from Raman markers assignments, Nucleic Acids Research, vol.27, issue.5, pp.1398-404, 1999.
DOI : 10.1093/nar/27.5.1398

A. Lever, H. Gottlinger, W. Haseltine, and J. Sodroski, Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions, J Virol, vol.63, pp.4085-4092, 1989.

C. Liang, L. Rong, M. Laughrea, L. Kleiman, and M. Wainberg, Compensatory point mutations in the human immunodeficiency virus type 1 Gag region that are distal from deletion mutations in the dimerization initiation site can restore viral replication, J Virol, vol.72, pp.6629-6665, 1998.

J. Lodmell, C. Ehresmann, B. Ehresmann, and R. Marquet, Convergence of natural and artificial evolution on an RNA loop???loop interaction: The HIV-1 dimerization initiation site, RNA, vol.6, issue.9, pp.1267-76, 2000.
DOI : 10.1017/S1355838200000698

J. Lodmell, C. Ehresmann, B. Ehresmann, and R. Marquet, Structure and dimerization of HIV-1 kissing loop aptamers, Journal of Molecular Biology, vol.311, issue.3, pp.475-90, 2001.
DOI : 10.1006/jmbi.2001.4879

J. Lodmell, J. Paillart, D. Mignot, B. Ehresmann, C. Ehresmann et al., Oligonucleotide-Mediated Inhibition of Genomic RNA Dimerization of HIV-1 Strains MAL and LAI: A Comparative Analysis, Antisense and Nucleic Acid Drug Development, vol.8, issue.6, pp.517-546, 1998.
DOI : 10.1089/oli.1.1998.8.517

A. Lund, J. Mikkelsen, J. Schmidt, M. Duch, and F. Pedersen, The kissing-loop motif is a preferred site of 5' leader recombination during replication of SL3-3 murine leukemia viruses in mice, J Virol, vol.73, pp.9614-9622, 1999.

S. Macura, Y. Huang, D. Suter, and R. Ernst, Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins, Journal of Magnetic Resonance (1969), vol.43, issue.2, pp.259-281, 1981.
DOI : 10.1016/0022-2364(81)90037-8

S. Macura, K. Wuthrich, and R. Ernst, Separation and supression of coherent transfert effects in two-dimensional NOE and chemical exchange spectroscopy, J Magn Reson, vol.46, pp.269-282, 1982.

A. Majumbar, Y. Gosser, and D. Patel, 1H-1H correlations across N-H...N hydrogen bonds in nucleic acids, Journal of Biomolecular NMR, vol.21, issue.4, pp.289-306, 2001.
DOI : 10.1023/A:1013340227140

W. Mangel, H. Delius, and P. Duesberg, Structure and Molecular Weight of the 60-70S RNA and the 30-40S RNA of the Rous Sarcoma Virus, Proceedings of the National Academy of Sciences, vol.71, issue.11, pp.4541-4546, 1974.
DOI : 10.1073/pnas.71.11.4541

D. Marion, M. Ikura, R. Tschudin, and A. Bax, Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins, Journal of Magnetic Resonance (1969), vol.85, issue.2, pp.393-399, 1989.
DOI : 10.1016/0022-2364(89)90152-2

D. Marion and K. Wuthrich, Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins, Biochemical and Biophysical Research Communications, vol.113, issue.3, pp.967-974, 1983.
DOI : 10.1016/0006-291X(83)91093-8

R. Marquet, F. Baudin, C. Gabus, J. Darlix, M. Mougel et al., Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism, Nucleic Acids Research, vol.19, issue.9, pp.2349-57, 1991.
DOI : 10.1093/nar/19.9.2349

R. Marquet, J. Paillart, E. Skripkin, C. Ehresmann, and B. Ehresmann, Dimerization of human immunodeficiency virus type 1 RNA involves sequences located upstream of the splice donor site, Nucleic Acids Research, vol.22, issue.2, pp.145-51, 1994.
DOI : 10.1093/nar/22.2.145

M. Mcbride and A. Panganiban, The human immunodeficiency virus type 1 encapsidation site is a multipartite RNA element composed of functional hairpin structures, J Virol, vol.70, pp.2963-73, 1996.

M. Mcbride, M. Schwartz, and A. Panganiban, Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation, J Virol, vol.71, pp.4544-54, 1997.

C. Meric, E. Gouilloud, and P. Spahr, Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): deletions of Cys-His boxes, J Virol, vol.62, pp.3328-3361, 1988.

C. Meric and P. Spahr, Rous sarcoma virus nucleic acid-binding protein p12 is necessary for viral 70S RNA dimer formation and packaging, J Virol, vol.60, pp.450-459, 1986.

G. Miele, A. Mouland, G. Harrison, E. Cohen, and A. Lever, The human immunodeficiency virus type 1 5' packaging signal structure affects translation but does not function as an internal ribosome entry site structure, J Virol, vol.70, pp.944-51, 1996.

J. Mikkelsen, A. Lund, M. Duch, and F. Pedersen, Recombination in the 5' leader of murine leukemia virus is accurate and influenced by sequence identity with a strong bias toward the kissing-loop dimerization region, J Virol, vol.72, pp.6967-78, 1998.

J. Mikkelsen, A. Lund, M. Duch, and F. Pedersen, Mutations of the Kissing-Loop Dimerization Sequence Influence the Site Specificity of Murine Leukemia Virus Recombination In Vivo, Journal of Virology, vol.74, issue.2, pp.600-610, 2000.
DOI : 10.1128/JVI.74.2.600-610.2000

J. Mikkelsen, A. Lund, K. Kristensen, M. Duch, M. Sorensen et al., A preferred region for recombinational patch repair in the 5' untranslated region of primer binding site-impaired murine leukemia virus vectors, J Virol, vol.70, pp.1439-1486, 1996.

J. Mikkelsen and F. Pedersen, Genetic reassortment and patch repair by recombination in retroviruses, Journal of Biomedical Science, vol.68, issue.2, pp.77-99, 2000.
DOI : 10.1007/BF02256615

J. Milligan, D. Groebe, G. Witherell, and O. Uhlenbeck, Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates, Nucleic Acids Research, vol.15, issue.21, pp.8783-98, 1987.
DOI : 10.1093/nar/15.21.8783

N. Morellet, H. De-rocquigny, Y. Mely, N. Jullian, H. Demene et al., Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR, Journal of Molecular Biology, vol.235, issue.1, pp.287-301, 1994.
DOI : 10.1016/S0022-2836(05)80033-6

N. Morellet, H. Demene, V. Teilleux, T. Huynh-dinh, H. De-rocquigny et al., Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC), Journal of Molecular Biology, vol.283, issue.2, pp.419-453, 1998.
DOI : 10.1006/jmbi.1998.2098

N. Morellet, N. Jullian, D. Rocquigny, H. Maigret, B. Darlix et al., Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR, Embo J, vol.11, pp.3059-65, 1992.

P. Morse, H. M. Feshbach, N. Tounekti, J. Darlix, J. Paoletti et al., Methods of Theoretical Physics, Part I. McGraw-Hill Conformational analysis of the 5' leader and the gag initiation site of Mo-MuLV RNA and allosteric transitions induced by dimerization, Nucleic Acids Res, vol.21, pp.4677-84, 1953.

A. Mujeeb, J. Clever, T. Billeci, T. James, and T. Parslow, Structure of the dimer a initiation complex of HIV-1 genomic RNA, Nature Structural Biology, vol.24, issue.6, pp.432-438, 1998.
DOI : 10.1006/jmbi.1997.1284

A. Mujeeb, S. Kerwin, G. Kenyon, and T. James, Solution structure of a conserved DNA sequence from the HIV-1 genome: Restrained molecular dynamics simulation with distance and torsion angle restraints derived from two-dimensional NMR spectra, Biochemistry, vol.32, issue.49, pp.13419-13450, 1993.
DOI : 10.1021/bi00212a007

A. Mujeeb, T. Parslow, A. Zarrinpar, C. Das, and T. James, NMR structure of the mature dimer initiation complex of HIV-1 genomic RNA, FEBS Letters, vol.1, issue.3, pp.387-92, 1999.
DOI : 10.1016/S0014-5793(99)01183-7

D. Muriaux, D. Rocquigny, H. Roques, B. Paoletti, and J. , NCp7 Activates HIV-1Lai RNA Dimerization by Converting a Transient Loop-Loop Complex into a Stable Dimer, Journal of Biological Chemistry, vol.271, issue.52, pp.33686-92, 1996.
DOI : 10.1074/jbc.271.52.33686

D. Muriaux, P. Girard, B. Bonnet-mathoniere, and J. Paoletti, Dimerization of HIV-1Lai RNA at Low Ionic Strength: AN AUTOCOMPLEMENTARY SEQUENCE IN THE 5' LEADER REGION IS EVIDENCED BY AN ANTISENSE OLIGONUCLEOTIDE, Journal of Biological Chemistry, vol.270, issue.14, pp.8209-8225, 1995.
DOI : 10.1074/jbc.270.14.8209

K. Murti, M. Bondurant, and A. Tereba, Secondary structural features in the 70S RNAs of Moloney murine leukemia and Rous sarcoma viruses as observed by electron microscopy, J Virol, vol.37, pp.411-430, 1981.

E. Nikonowicz, M. Michnicka, K. Kalurachchi, and E. Dejong, Preparation and characterization of a uniformly 2 H/ 15 N-labeled RNA oligonucleotide for NMR studies, Nucleic Acids Research, vol.25, issue.7, pp.1390-1396, 1997.
DOI : 10.1093/nar/25.7.1390

M. Nilges, G. Clore, and A. Gronenborn, Determination of three-dimensional structures of proteins from interproton distance data by hybrid distance geometry-dynamical simulated annealing calculations, FEBS Letters, vol.4, issue.2, pp.317-341, 1988.
DOI : 10.1016/0014-5793(88)81148-7

G. Otting and K. Wuthrich, Extended heteronuclear editing of 2D 1H NMR spectra of isotope-labeled proteins, using the X(??1, ??2) double half filter, Journal of Magnetic Resonance (1969), vol.85, issue.3, pp.586-94, 1989.
DOI : 10.1016/0022-2364(89)90249-7

J. Paillart, L. Berthoux, M. Ottmann, J. Darlix, R. Marquet et al., A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis, J Virol, vol.70, pp.8348-54, 1996.

J. Paillart, R. Marquet, E. Skripkin, B. Ehresmann, and C. Ehresmann, Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA, J Biol Chem, vol.269, pp.27486-93, 1994.

J. Paillart, R. Marquet, E. Skripkin, C. Ehresmann, and B. Ehresmann, Dimerization of retroviral genomic RNAs: structural and functional implications, Biochimie, vol.78, issue.7, pp.639-53, 1996.
DOI : 10.1016/S0300-9084(96)80010-1

J. Paillart, E. Skripkin, B. Ehresmann, C. Ehresmann, and R. Marquet, A loop-loop "kissing" complex is the essential part of the dimer linkage of genomic HIV-1 RNA., Proceedings of the National Academy of Sciences, vol.93, issue.11, pp.5572-5579, 1996.
DOI : 10.1073/pnas.93.11.5572

J. Paillart, E. Westhof, C. Ehresmann, B. Ehresmann, and R. Marquet, Non-canonical interactions in a kissing loop complex: the dimerization initiation site of HIV-1 genomic RNA, Journal of Molecular Biology, vol.270, issue.1, pp.36-49, 1997.
DOI : 10.1006/jmbi.1997.1096

J. Paoletti, M. Mougel, N. Tounekti, P. Girard, C. Ehresmann et al., Spontaneous dimerization of retroviral MoMuLV RNA, Biochimie, vol.75, issue.8, pp.681-687, 1993.
DOI : 10.1016/0300-9084(93)90099-E

K. Pervushin, A. Ono, C. Fernandez, T. Szyperski, M. Kainosho et al., NMR scalar couplings across Watson-Crick base pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy, Proceedings of the National Academy of Sciences, vol.39, issue.5340, pp.14147-51, 1998.
DOI : 10.1126/science.278.5340.1111

K. Pervushin, R. Riek, G. Wider, and K. Wuthrich, Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution, Proceedings of the National Academy of Sciences, vol.40, issue.6, pp.12366-71, 1997.
DOI : 10.1007/BF02192855

M. Piotto, V. Saudek, and V. Sklenar, Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions, Journal of Biomolecular NMR, vol.87, issue.6, pp.661-666, 1992.
DOI : 10.1007/BF02192855

P. Plateau and M. Gueron, ChemInform Abstract: EXCHANGEABLE PROTON NMR WITHOUT BASE-LINE DISTORSION, USING NEW STRONG-PULSE SEQUENCES, Chemischer Informationsdienst, vol.104, issue.12, pp.7310-7321, 1982.
DOI : 10.1002/chin.198312045

H. Pley, K. Flaherty, and D. Mckay, Three-dimensional structure of a hammerhead ribozyme, Nature, vol.372, issue.6501, pp.68-74, 1994.
DOI : 10.1038/372068a0

E. Polge, J. Darlix, J. Paoletti, and P. Fosse, Characterization of loose and tight dimer forms of avian leukosis virus RNA, Journal of Molecular Biology, vol.300, issue.1, pp.41-56, 2000.
DOI : 10.1006/jmbi.2000.3832
URL : https://hal.archives-ouvertes.fr/hal-00289724

D. Poon, G. Li, and A. Aldovini, Nucleocapsid and matrix protein contributions to selective human immunodeficiency virus type 1 genomic RNA packaging, J Virol, vol.72, pp.1983-93, 1998.

D. Poon, J. Wu, and A. Aldovini, Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity, J Virol, vol.70, pp.6607-6623, 1996.

M. Powell, Restart procedures for the conjugate gradient method, Mathematical Programming, vol.11, issue.1, pp.241-54, 1977.
DOI : 10.1007/BF01593790

A. Prats, C. Roy, P. Wang, M. Erard, V. Housset et al., cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA, J Virol, vol.64, pp.774-83, 1990.

J. Prestegard, H. Hashimi, and J. Tolman, NMR structures of biomolecules using field oriented media and residual dipolar couplings, Quarterly Reviews of Biophysics, vol.33, issue.4, pp.371-424, 2000.
DOI : 10.1017/S0033583500003656

E. Puglisi and J. Puglisi, Nuclear magnetic resonance spectroscopy of RNA Mechanism of nucleocapsid protein catalyzed structural isomerization of the dimerization initiation site of HIV-1, Biochemistry, vol.41, pp.14762-70, 1998.

C. Roy, N. Tounekti, M. Mougel, J. Darlix, C. Paoletti et al., generated RNA of Moloney murine leukemia virus MoMuLV, Nucleic Acids Research, vol.18, issue.24, pp.7287-92, 1990.
DOI : 10.1093/nar/18.24.7287

W. M. Saenger, K. Pervushin, G. Wider, H. Senn, and K. Wuthrich, Principles of Nucleic Acid Structure TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins, Proc Natl Acad Sci, vol.95, pp.13585-90, 1984.

J. Santalucia, J. Turner, and D. , Structure of (rGGCGAGCC)2 in solution from NMR and restrained molecular dynamics, Biochemistry, vol.32, issue.47, pp.12612-12635, 1993.
DOI : 10.1021/bi00210a009

E. Schmalzbauer, B. Strack, J. Dannull, S. Guehmann, and K. Moelling, Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro, J Virol, vol.70, pp.771-778, 1996.

M. Schwartz, D. Fiore, and A. Panganiban, Distinct functions and requirements for the Cys-His boxes of the human immunodeficiency virus type 1 nucleocapsid protein during RNA encapsidation and replication, J Virol, vol.71, pp.9295-305, 1997.

W. Scott, J. Finch, and A. Klug, The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage, Cell, vol.81, issue.7, pp.991-1002, 1995.
DOI : 10.1016/S0092-8674(05)80004-2

A. Shaka, P. Barker, and R. Freeman, Computer-optimized decoupling scheme for wide band applications and low level operation, J Magn Reson, vol.64, pp.547-552, 1985.

A. Shaka, J. Keeler, and R. Freeman, Evolution of a new broadband decoupling sequence: WALTZ-16, J Magn Reson, vol.53, pp.313-340, 1983.

N. Shen, L. Jette, C. Liang, M. Wainberg, and M. Laughrea, Impact of Human Immunodeficiency Virus Type 1 RNA Dimerization on Viral Infectivity and of Stem-Loop B on RNA Dimerization and Reverse Transcription and Dissociation of Dimerization from Packaging, Journal of Virology, vol.74, issue.12, pp.5729-5764, 2000.
DOI : 10.1128/JVI.74.12.5729-5735.2000

E. Skripkin, J. Paillart, R. Marquet, M. Blumenfeld, B. Ehresmann et al., Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides, J Biol Chem, vol.271, pp.28812-28819, 1996.

E. Skripkin, J. Paillart, R. Marquet, B. Ehresmann, and C. Ehresmann, Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro., Proceedings of the National Academy of Sciences, vol.91, issue.11, pp.4945-4954, 1994.
DOI : 10.1073/pnas.91.11.4945

E. Stein, L. Rice, and A. Brunger, Torsion-Angle Molecular Dynamics as a New Efficient Tool for NMR Structure Calculation, Journal of Magnetic Resonance, vol.124, issue.1, pp.154-64, 1997.
DOI : 10.1006/jmre.1996.1027

M. Summers, T. South, B. Kim, and D. Hare, High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach, Biochemistry, vol.29, issue.2, pp.329-369, 1990.
DOI : 10.1021/bi00454a005

W. Sundquist and S. Heaphy, Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA., Proceedings of the National Academy of Sciences, vol.90, issue.8, pp.3393-3400, 1993.
DOI : 10.1073/pnas.90.8.3393

A. Surovoy, J. Dannull, K. Moelling, and G. Jung, Conformational and Nucleic Acid Binding Studies on the Synthetic Nucleocapsid Protein of HIV-1, Journal of Molecular Biology, vol.229, issue.1, pp.94-104, 1993.
DOI : 10.1006/jmbi.1993.1011

K. Takahashi, S. Baba, Y. Hayashi, Y. Koyanagi, N. Yamamoto et al., NMR Analysis of Intra- and Inter-Molecular Stems in the Dimerization Initiation Site of the HIV-1 Genome, Journal of Biochemistry, vol.127, issue.4, pp.681-687, 2000.
DOI : 10.1093/oxfordjournals.jbchem.a022657

K. Takahashi, S. Baba, Y. Koyanagi, N. Yamamoto, H. Takaku et al., Two Basic Regions of NCp7 Are Sufficient for Conformational Conversion of HIV-1 Dimerization Initiation Site from Kissing-loop Dimer to Extended-duplex Dimer, Journal of Biological Chemistry, vol.276, issue.33, pp.31274-31282, 2001.
DOI : 10.1074/jbc.M104577200

K. Takahashi, S. Baba, P. Chattopadhyay, Y. Koyanagi, N. Yamamoto et al., Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome, RNA, vol.6, issue.1, pp.96-102, 2000.
DOI : 10.1017/S1355838200991635

V. Tereshko, S. Wallace, N. Usman, F. Wincott, and M. Egli, X-ray crystallographic observation of ???in-line??? and ???adjacent??? conformations in a bulged self-cleaving RNA/DNA hybrid, RNA, vol.7, issue.3, pp.405-425, 2001.
DOI : 10.1017/S1355838201001935

V. Theilleux-delalande, V. Theilleux-delalande, F. Girard, T. Huynh-dinh, G. Lancelot et al., The HIV-1Lai RNA dimerization, European Journal of Biochemistry, vol.267, issue.9, pp.2711-2720, 1998.
DOI : 10.1046/j.1432-1327.2000.01292.x

N. Tjandra, J. Omichinski, A. Gronenborn, G. Clore, and A. Bax, Use of dipolar 1H???15N and 1H???13C couplings in the structure determination of magnetically oriented macromolecules in solution, Nature Structural Biology, vol.2, issue.9, pp.732-740, 1997.
DOI : 10.1107/S0021889892009944

B. Turner and M. Summers, Structural biology of HIV, Journal of Molecular Biology, vol.285, issue.1, pp.1-32, 1999.
DOI : 10.1006/jmbi.1998.2354

G. Varani, C. Cheong, I. Tinoco, and J. , Structure of an unusually stable RNA hairpin, Biochemistry, vol.30, issue.13, pp.3280-3289, 1991.
DOI : 10.1021/bi00227a016

L. Verlet, Computer "Experiments" on Classical Fluids. I. Thermodynamical Properties of Lennard-Jones Molecules, Physical Review, vol.159, issue.1, pp.98-105, 1967.
DOI : 10.1103/PhysRev.159.98

Y. Wang, S. Huang, and D. Draper, Structure of a U{middle dot}U Pair Within a Conserved Ribosomal RNA Hairpin, Nucleic Acids Research, vol.24, issue.14, pp.2666-72, 1996.
DOI : 10.1093/nar/24.14.2666

S. Wijmenga, M. Kruithof, and C. Hilbers, Analysis of 1H chemical shifts in DNA: Assesment of the reliability of 1H chemical shift calculations for use in structure refinement, Journal of Biomolecular NMR, vol.10, issue.4, pp.337-50, 1997.
DOI : 10.1023/A:1018348123074

S. Wijmenga and B. Van-buuren, The use of NMR methods for conformationnal studies of nucleic acids, Prog Nucl Magn Reson Spec, vol.34, pp.287-387, 1998.

N. Windbichler, M. Werner, and R. Schroeder, Kissing complex-mediated dimerisation of HIV-1 RNA: coupling extended duplex formation to ribozyme cleavage, Nucleic Acids Research, vol.31, issue.22, pp.6419-6446, 2003.
DOI : 10.1093/nar/gkg873

C. Woese, S. Winker, and R. Gutell, Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops"., Proceedings of the National Academy of Sciences, vol.87, issue.21, pp.8467-71, 1990.
DOI : 10.1073/pnas.87.21.8467

J. Wyatt, M. Chastain, and J. Puglisi, Synthesis and purification of large amounts of RNA oligonucleotides, Biotechniques, vol.11, pp.764-773, 1991.

S. Yamakage, T. Maltseva, F. Nilson, A. Foldesi, and J. Chattopadhyaya, Deuteriation of sugar protons simplify NMR assignments and structure determination of large oligonucleotide by the 1H-NMR window approach, Nucleic Acids Res, vol.21, pp.5005-5016, 1993.

X. Zhang and D. Patel, Solution structure of the luzopeptin-DNA complex, Biochemistry, vol.30, issue.16, pp.4026-4067, 1991.
DOI : 10.1021/bi00230a030

Y. Zhang and E. Barklis, Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation, J Virol, vol.71, pp.6765-76, 1997.