Etude structurale par RMN des changements conformationnels de la séquence SL1 de l'ARN de l'isolat VIH-1 laï

Abstract : Like all retroviruses, the human immunodeficience virus (HIV) genome is made up of two identical copies of genomic RNA. Those are related in a non covalent way to their 5' leader. The dimerization phenomenon interferes with various key stages of the retroviral cycle life, including encapsidation and maturation of the virion. The dimerization inhibition represents a new way of processing against HIV. This work concerns the NMR structural study of different conformations for the SL1 RNA fragment. This sequence initiates the retrovirus dimerization. It was a first approach for the comprehension of the interactions between the both RNA of VIH-1Laï during the dimerization step. These structural investigations constitute a solid base study in the drug-design strategies implying the development of inhibitors likely to interfere with the dimerization phenomenon
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Submitted on : Thursday, December 16, 2004 - 3:10:01 PM
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  • HAL Id : tel-00007782, version 1

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Fabien Kieken. Etude structurale par RMN des changements conformationnels de la séquence SL1 de l'ARN de l'isolat VIH-1 laï. Autre. Université d'Orléans, 2004. Français. ⟨tel-00007782⟩

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