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Empreinte génomique parentale et petits ARN non-codants

Abstract : Genomic imprinting results in a differential expression of both alleles of some genes, according to their parental origin. This study led to the identification of many mammalian small non-coding RNA genes (C/D RNA and microRNA genes) which are subjected to genomic imprinting, and to a preliminary characterization of their expression. Whereas most C/D RNAs participate to ribosomal RNA or small nuclear RNA biogenesis, the ones we describe don't seem to ; microRNAs are usually post-transcriptional repressors of specific genes : among the microRNAs we describe, two could repress a retrotransposon. Potential functions for those small non-coding RNA genes (in development control, retrotransposon silencing and genomic imprinting mechanism) are discussed.
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Contributor : Hervé Seitz <>
Submitted on : Thursday, December 16, 2004 - 4:06:10 PM
Last modification on : Wednesday, January 20, 2021 - 3:26:04 PM
Long-term archiving on: : Wednesday, November 23, 2016 - 5:31:11 PM


  • HAL Id : tel-00007781, version 1



Hervé Seitz. Empreinte génomique parentale et petits ARN non-codants. Biochimie [q-bio.BM]. Université Paul Sabatier - Toulouse III, 2004. Français. ⟨tel-00007781⟩



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