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Analyse moléculaire du myélome: vers de nouvelles perspectives thérapeutiques

Abstract : Accumulating evidence has suggested that the transformation of a normal plasma cell into a malignant myeloma cell is a multiple-step process. Genotypic changes are found in 60% of patients at diagnosis by conventional karyotyping and in up to 90% of patients
by FISH analysis. The portrayal of this complex alteration of the cellular circuitry and cellular behavior in myeloma cells will best be apprehended by the use of DNA microarrays. Indeed, gene-expression profiling using microarrays allows the simultaneous analysis of multiple markers and is thus an ideal tool to study the global changes that drive a normal cell to malignancy. Among the numerous genes that have a higher expression level in malignant plasma cells, we have focused our study on a few genes that encode for proteins that could be involved in myeloma biology or could be potential therapeutic targets such as HB-EGF.
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Contributor : John de Vos <>
Submitted on : Thursday, June 3, 2004 - 5:30:50 PM
Last modification on : Friday, October 23, 2020 - 4:34:16 PM
Long-term archiving on: : Friday, April 2, 2010 - 8:52:59 PM


  • HAL Id : tel-00006190, version 1



John de Vos. Analyse moléculaire du myélome: vers de nouvelles perspectives thérapeutiques. Sciences du Vivant [q-bio]. Université Montpellier I, 2001. Français. ⟨tel-00006190⟩



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